{"title":"Electrochemistry-enabled Rh-catalyzed regioselective [4 + 1] and [4 + 2] cycloaddition of benzoic acid with alkynyl esters/amides†‡","authors":"Wei-Jung Chiu , Chung-Ming Sun","doi":"10.1039/d4gc03753g","DOIUrl":null,"url":null,"abstract":"<div><div>A Rh(<span>iii</span>)-catalyzed additive-controlled regioselective [4 + 1] and [4 + 2] cyclization of benzoic acids with alkynyl esters/amides under electrochemical conditions has been developed for the synthesis of phthalides and isocoumarins. The selectivity for the product formation was attained by merely changing the additive. Employment of NaOAc in the reaction produces isocoumarins whereas AcOH favors phthalides. Cyclic voltammetry and control experiments reveal the mechanistic pathway of the reaction.</div></div>","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":"26 21","pages":"Pages 10996-11002"},"PeriodicalIF":9.2000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1463926224008252","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/2 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A Rh(iii)-catalyzed additive-controlled regioselective [4 + 1] and [4 + 2] cyclization of benzoic acids with alkynyl esters/amides under electrochemical conditions has been developed for the synthesis of phthalides and isocoumarins. The selectivity for the product formation was attained by merely changing the additive. Employment of NaOAc in the reaction produces isocoumarins whereas AcOH favors phthalides. Cyclic voltammetry and control experiments reveal the mechanistic pathway of the reaction.
期刊介绍：
Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.
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