First WGS Characterization of Streptococcus suis Isolated From a Case of Human Meningitis in Southern Italy

IF 3.5 2区农林科学 Q2 INFECTIOUS DISEASES Transboundary and Emerging Diseases Pub Date : 2024-10-25 DOI:10.1155/2024/4529326

Giovanna Fusco, Saveria Dodaro, Maria Vittoria Mauro, Francesca Greco, Lorella Barca, Rubina Paradiso, Antonio Limone, Maria Garzi Cosentino, Agata Campione, Giovanna De Luca, Bianca Cecere, Sonia Greco, Valeria Vangeli, Esterina De Carlo, Giorgia Borriello, Antonio Mastroianni

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Abstract

This study is the first report in Italy on the molecular characterization by whole-genome sequencing (WGS) analysis of a Streptococcus suis strain isolated from a human case of meningitis in Italy. The characterized S. suis strain was classified as a serotype 2 (SS2), multilocus sequence typing (MLST) sequence type ST1. The strain exhibited the presence of several virulence genes and resistance to penicillin, tetracycline and macrolide–lincosamide–streptogramin. Finally, we found a frameshift mutation in the gene mrp determining the translation of two truncated forms of the corresponding muramidase-release protein. These results highlight the importance of complete genomic data to understand the pathogenesis and epidemiology of this bacterium, capable to pose serious risks to human health.

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从意大利南部一例人类脑膜炎病例中分离出的猪链球菌的首次 WGS 特征描述

本研究是意大利首次报道通过全基因组测序（WGS）分析从意大利一例人类脑膜炎病例中分离出的猪链球菌菌株的分子特征。表征的猪链球菌菌株被归类为血清型 2（SS2）、多焦点序列分型（MLST）序列类型 ST1。该菌株含有多个毒力基因，对青霉素、四环素和大环内酯-林可霉素-链霉亲和素具有抗性。最后，我们在基因 mrp 中发现了一个框架移位突变，该突变决定了相应的蕈酶释放蛋白的两种截短形式的翻译。这些结果凸显了完整的基因组数据对于了解这种可能对人类健康造成严重危害的细菌的致病机理和流行病学的重要性。

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来源期刊

Transboundary and Emerging Diseases 农林科学-传染病学

CiteScore

8.90

自引率

9.30%

发文量

350

审稿时长

1 months

期刊介绍： Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions): Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread. Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope. Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies. Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies). Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.