Characteristics of Fungal Monosensitization in Turkey

IF 0.3 4区医学 Revue Francaise d Allergologie Pub Date : 2024-10-18 DOI:10.1016/j.reval.2024.104162

S. Gültuna , D.G.U. Erkaya , Y.S. Demirel , O. Aydın

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Abstract

Study Objective

Fungi are recognized as allergenic sources and may play a role in the development, persistency, and severity of allergic diseases. Alternaria, Cladosporium, Penicillium, and Aspergillus, which belong to the Phylum Ascomycota, are well-characterized four genera among fungi species. To our knowledge, there is not enough data about monosensitization to fungi. We aimed to investigate the characteristics of monosensitized patients to fungal allergens.

Patients-Methods

Sixty-seven adult patients, who had a positive skin prick test reaction with fungal allergen out of a total of 4200 SPT results performed between January 2015 and June 2022 in two tertiary centers were included in the study. The clinical data of the patients were obtained retrospectively from the hospital medical records.

Results

Fifty-six (83.6%) patients were sensitized to one type of fungal allergen (Female/Male: 38/18) and eleven (16.4%) (Female/Male: 9/2) were sensitized to two types of fungi. Aspergillus was the most prevalent fungal allergen, followed by Cladosporium and Alternaria. Allergic rhinitis was the most common allergic disease.

Conclusion

Monosensitization to fungal allergens is rare. Monosensitization to at least one fungal allergen may lead to significant allergic diseases by potentially impacting the immune system.

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土耳其真菌单敏性的特点

研究目的真菌是公认的过敏源，可能在过敏性疾病的发生、持续和严重程度中起作用。属于子囊菌门的 Alternaria、Cladosporium、Penicillium 和 Aspergillus 是真菌中特征明显的四个属。据我们所知，关于真菌单敏性的数据还不够多。我们的目的是调查对真菌过敏原单敏患者的特征。患者-方法研究纳入了 67 名成年患者，他们在 2015 年 1 月至 2022 年 6 月期间在两家三级医院进行的总共 4200 次 SPT 结果中，对真菌过敏原的皮肤点刺试验反应呈阳性。结果56名（83.6%）患者对一种真菌过敏原过敏（女性/男性：38/18），11名（16.4%）患者对两种真菌过敏（女性/男性：9/2）。曲霉菌是最常见的真菌过敏原，其次是Cladosporium和Alternaria。过敏性鼻炎是最常见的过敏性疾病。对至少一种真菌过敏原单敏可能会影响免疫系统，从而导致严重的过敏性疾病。

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来源期刊

Revue Francaise d Allergologie Medicine-Immunology and Allergy

自引率

33.30%

发文量

349

期刊介绍： La Revue Française d''Allergologie : un véritable forum pour faire connaître des travaux originaux et permettre la diffusion de l''information auprès de toutes les spécialités concernées par les pathologies allergiques. La Revue Française d''Allergologie (8 numéros par an) est au carrefour de nombreuses spécialités - dermatologie, pédiatrie, ORL, pneumologie, ophtalmologie, médecine interne - qui, toutes, ont à traiter des maladies allergiques. Les symptômes des allergies fondés sur des mécanismes communs sont le plus souvent associés et se succèdent chez un même patient. En forte progression depuis 20 ans, les maladies allergiques sont dans l''attente de perfectionnements et d''avancées thérapeutiques qui permettront aux nombreux patients qui en sont atteints de mieux vivre avec leurs allergies. La Revue Française d''Allergologie se veut donc un véritable forum de discussions et d''échanges entre tous les spécialistes confrontés aux pathologies