Pub Date : 2026-01-09DOI: 10.1016/j.reval.2025.104641
M. Bodinier
{"title":"Rôle de la barrière intestinale dans les allergies alimentaires","authors":"M. Bodinier","doi":"10.1016/j.reval.2025.104641","DOIUrl":"10.1016/j.reval.2025.104641","url":null,"abstract":"","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 ","pages":"Article 104641"},"PeriodicalIF":0.3,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145929329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30DOI: 10.1016/j.reval.2025.104635
Sofia Gueroum, Fatima-Zahra ElFatoiki, Fouzia Hali, Soumiya Chiheb
{"title":"Dermatite de contact chronique au Parthenium à l’ère du changement climatique : efficacité de l’azathioprine","authors":"Sofia Gueroum, Fatima-Zahra ElFatoiki, Fouzia Hali, Soumiya Chiheb","doi":"10.1016/j.reval.2025.104635","DOIUrl":"10.1016/j.reval.2025.104635","url":null,"abstract":"","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 2","pages":"Article 104635"},"PeriodicalIF":0.3,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145847535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30DOI: 10.1016/j.reval.2025.104636
M. Mesbah, S. Martinez, C. Gonzalez, N. Touati Leray
An Indoor Environmental Advisor is a health professional trained to diagnose household environment of patients suffering from respiratory illnesses (mostly allergic asthma). They only intervene with a medical prescription. In order to evaluate the impact of the advisor's intervention on the patient's respiratory illness, a retrospective study was conducted from 2011 to 2022, over 648 house visits, through a form sent 6 months following the visit. In all, 164 forms were analyzed (25% of visited patients). The aim is to show the impact of these visits on the patient's health. Three out of four patients reported a global improvement in their health as well as a decrease in the number of attacks and crisis. For a quarter of patients, the ongoing disease treatment was stopped. Half of the patients are less absent (at work or school) and less often need to consult their physician or to be hospitalized. This declarative retrospective study contains biases but showcases a strong trend (namely health improvements, lower meds consumption, less hospitalizations) which are in agreement with those observed on numerous studies on the medical usefulness of the role of the Indoor Environment Advisor.
{"title":"Impact de l’intervention d’une conseillère en environnement intérieur à domicile, sur l’évolution de la santé des patients visités – étude rétrospective de onze ans de pratique (2011–2022)","authors":"M. Mesbah, S. Martinez, C. Gonzalez, N. Touati Leray","doi":"10.1016/j.reval.2025.104636","DOIUrl":"10.1016/j.reval.2025.104636","url":null,"abstract":"<div><div>An Indoor Environmental Advisor is a health professional trained to diagnose household environment of patients suffering from respiratory illnesses (mostly allergic asthma). They only intervene with a medical prescription. In order to evaluate the impact of the advisor's intervention on the patient's respiratory illness, a retrospective study was conducted from 2011 to 2022, over 648 house visits, through a form sent 6 months following the visit. In all, 164 forms were analyzed (25% of visited patients). The aim is to show the impact of these visits on the patient's health. Three out of four patients reported a global improvement in their health as well as a decrease in the number of attacks and crisis. For a quarter of patients, the ongoing disease treatment was stopped. Half of the patients are less absent (at work or school) and less often need to consult their physician or to be hospitalized. This declarative retrospective study contains biases but showcases a strong trend (namely health improvements, lower meds consumption, less hospitalizations) which are in agreement with those observed on numerous studies on the medical usefulness of the role of the Indoor Environment Advisor.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 2","pages":"Article 104636"},"PeriodicalIF":0.3,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145847707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30DOI: 10.1016/j.reval.2025.104624
M. Özer
Introduction
Food protein-induced enterocolitis syndrome (FPIES) is a rare form of non-IgE-mediated food allergy that typically presents in infancy. The clinical picture is usually characterized by delayed-onset, repetitive severe vomiting. Due to these symptoms, FPIES can be easily confused with acute abdominal conditions requiring surgical intervention, such as intussusception, and must therefore be considered in the differential diagnosis.
Case report
A previously healthy six-month-old male infant presented to the emergency department with profuse vomiting and lethargy approximately one hour after ingesting yogurt for the first time. Evaluation revealed intussusception, and surgical intervention was performed. Due to the history of recurrent vomiting and lethargy after yogurt ingestion, FPIES was considered as a preliminary diagnosis. At nine months of age, an open oral food challenge was performed, which confirmed the diagnosis of FPIES.
Conclusion
This case demonstrates that FPIES may not only mimic intussusception but also predispose to this complication. Therefore, FPIES should be considered in the differential diagnosis of infants presenting with gastrointestinal symptoms, and complications such as intussusception should be recognized as potentially associated with FPIES, particularly in cases of persistent vomiting despite ondansetron.
{"title":"FPIES presenting as intussusception: A rare mimic or a triggered complication?","authors":"M. Özer","doi":"10.1016/j.reval.2025.104624","DOIUrl":"10.1016/j.reval.2025.104624","url":null,"abstract":"<div><h3>Introduction</h3><div>Food protein-induced enterocolitis syndrome (FPIES) is a rare form of non-IgE-mediated food allergy that typically presents in infancy. The clinical picture is usually characterized by delayed-onset, repetitive severe vomiting. Due to these symptoms, FPIES can be easily confused with acute abdominal conditions requiring surgical intervention, such as intussusception, and must therefore be considered in the differential diagnosis.</div></div><div><h3>Case report</h3><div>A previously healthy six-month-old male infant presented to the emergency department with profuse vomiting and lethargy approximately one hour after ingesting yogurt for the first time. Evaluation revealed intussusception, and surgical intervention was performed. Due to the history of recurrent vomiting and lethargy after yogurt ingestion, FPIES was considered as a preliminary diagnosis. At nine months of age, an open oral food challenge was performed, which confirmed the diagnosis of FPIES.</div></div><div><h3>Conclusion</h3><div>This case demonstrates that FPIES may not only mimic intussusception but also predispose to this complication. Therefore, FPIES should be considered in the differential diagnosis of infants presenting with gastrointestinal symptoms, and complications such as intussusception should be recognized as potentially associated with FPIES, particularly in cases of persistent vomiting despite ondansetron.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 2","pages":"Article 104624"},"PeriodicalIF":0.3,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145847758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-26DOI: 10.1016/j.reval.2025.104618
C. André, C. Bara, H. Maillard
Introduction
Drug provocation tests are gold standard to confirm or exclude drug allergy. Few studies have specifically investigated patients’ adherence after a negative test and the determinants of their level of trust in the procedure. We aimed to assess both the trust level and the intention to resume the reintroduced drugs in adult patients who had completed a full allergology workup, including a negative drug provocation test.
Methods
This retrospective, cross-sectional, observational, descriptive, and analytical study was conducted in the Allergy unit of Le Mans hospital between April and July 2025. It included 305 drug provocation tests with negative outcomes performed in 230 patients reintroduced between 2017 and 2021.
Results
A total of 64.3% of surveyed patients reported a satisfactory trust level (at least 7/10) in the drug provocation tests for a future resumption of the drug. Among our patients, 35.4 % had already resumed the treatment after reintroduction. The mean trust score was 7.02/10, rising to 8.90/10 among “confident” patients who were willing to resume the drug at home. The reintroduction of a corticosteroid or the presence of polyallergy in the patient's record appeared to be the two main factors of reluctance to resume treatment. Forty-four percent of patients did not recall having a written record of the drug provocation test outcome.
Conclusion
We found post-drug provocation test adherence to be consistent with the literature. A specific focus on patients at high risk of non-adherence could improve their level of treatment resumption. Providing a document confirming the absence of allergy, or adding a “drug tested and reintroduced” note to the patient's digital health record, appear to be promising approaches to counter forgetting and/or misreporting to healthcare professionals managing the patient in the future.
{"title":"Réintroduction médicamenteuse en allergologie : niveau de confiance et intention de reprise","authors":"C. André, C. Bara, H. Maillard","doi":"10.1016/j.reval.2025.104618","DOIUrl":"10.1016/j.reval.2025.104618","url":null,"abstract":"<div><h3>Introduction</h3><div>Drug provocation tests are gold standard to confirm or exclude drug allergy. Few studies have specifically investigated patients’ adherence after a negative test and the determinants of their level of trust in the procedure. We aimed to assess both the trust level and the intention to resume the reintroduced drugs in adult patients who had completed a full allergology workup, including a negative drug provocation test.</div></div><div><h3>Methods</h3><div>This retrospective, cross-sectional, observational, descriptive, and analytical study was conducted in the Allergy unit of Le Mans hospital between April and July 2025. It included 305 drug provocation tests with negative outcomes performed in 230 patients reintroduced between 2017 and 2021.</div></div><div><h3>Results</h3><div>A total of 64.3% of surveyed patients reported a satisfactory trust level (at least<!--> <!-->7/10) in the drug provocation tests for a future resumption of the drug. Among our patients, 35.4 % had already resumed the treatment after reintroduction. The mean trust score was 7.02/10, rising to 8.90/10 among “confident” patients who were willing to resume the drug at home. The reintroduction of a corticosteroid or the presence of polyallergy in the patient's record appeared to be the two main factors of reluctance to resume treatment. Forty-four percent of patients did not recall having a written record of the drug provocation test outcome.</div></div><div><h3>Conclusion</h3><div>We found post-drug provocation test adherence to be consistent with the literature. A specific focus on patients at high risk of non-adherence could improve their level of treatment resumption. Providing a document confirming the absence of allergy, or adding a “drug tested and reintroduced” note to the patient's digital health record, appear to be promising approaches to counter forgetting and/or misreporting to healthcare professionals managing the patient in the future.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104618"},"PeriodicalIF":0.3,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.reval.2025.104637
M. Amaziane , F. Makhloufi , S. Benchekroun , C. Mahraoui , N. El Hafidi
Background
Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency characterized by a classic triad of eczema, recurrent infections and microthrombocytopenia. Opportunistic infections are the leading cause of morbidity and mortality, underscoring the critical importance of cotrimoxazole (CMX) prophylaxis. However, CMX can cause cutaneous hypersensitivity reactions, which are particularly challenging in patients with WAS.
Case presentation
We describe the occurrence of an eczematous rash in an 11-month-old infant with WAS shortly after the initiation of CMX. Since the patient had also received intravenous immunoglobulin and antituberculous therapy, a comprehensive medication timeline was reconstructed in order to identify the causative agent. According to this analysis, the most likely trigger was CMX. In order to maintain prophylaxis, an oral desensitization protocol was subsequently implemented.
Results
Oral desensitization over three days was well tolerated, allowing full target daily dose administration without recurrence of cutaneous reaction and maintaining essential antibiotic prophylaxis.
Conclusion
Oral CMX desensitization is a safe and effective strategy in infants with WAS, for whom therapeutic alternatives are limited. Standardization and dissemination of pediatric desensitization protocols are necessary to improve patient care.
{"title":"Désensibilisation au cotrimoxazole chez un nourrisson marocain atteint du syndrome de Wiskott-Aldrich : rapport de cas","authors":"M. Amaziane , F. Makhloufi , S. Benchekroun , C. Mahraoui , N. El Hafidi","doi":"10.1016/j.reval.2025.104637","DOIUrl":"10.1016/j.reval.2025.104637","url":null,"abstract":"<div><h3>Background</h3><div>Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency characterized by a classic triad of eczema, recurrent infections and microthrombocytopenia. Opportunistic infections are the leading cause of morbidity and mortality, underscoring the critical importance of cotrimoxazole (CMX) prophylaxis. However, CMX can cause cutaneous hypersensitivity reactions, which are particularly challenging in patients with WAS.</div></div><div><h3>Case presentation</h3><div>We describe the occurrence of an eczematous rash in an 11-month-old infant with WAS shortly after the initiation of CMX. Since the patient had also received intravenous immunoglobulin and antituberculous therapy, a comprehensive medication timeline was reconstructed in order to identify the causative agent. According to this analysis, the most likely trigger was CMX. In order to maintain prophylaxis, an oral desensitization protocol was subsequently implemented.</div></div><div><h3>Results</h3><div>Oral desensitization over three days was well tolerated, allowing full target daily dose administration without recurrence of cutaneous reaction and maintaining essential antibiotic prophylaxis.</div></div><div><h3>Conclusion</h3><div>Oral CMX desensitization is a safe and effective strategy in infants with WAS, for whom therapeutic alternatives are limited. Standardization and dissemination of pediatric desensitization protocols are necessary to improve patient care.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104637"},"PeriodicalIF":0.3,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.reval.2025.104620
Öner Özdemir
{"title":"Importance of neutrophil-lymphocyte, platelet-lymphocyte ratio in urticaria","authors":"Öner Özdemir","doi":"10.1016/j.reval.2025.104620","DOIUrl":"10.1016/j.reval.2025.104620","url":null,"abstract":"","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104620"},"PeriodicalIF":0.3,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.reval.2025.104640
E. Bahadir, B. Can Duran, S. Demirsöz, C. Aytekin, S. Özmen
Pomegranate (Punica granatum) is a fruit rich in antioxidants and commonly consumed worldwide. However, although generally well tolerated, it has rarely been implicated in severe allergic reactions, including anaphylaxis. We report the case of a 3.5-year-old boy with a five-month history of recurrent periorbital angioedema. Careful history revealed pomegranate ingestion preceding one of these episodes. During an oral food challenge with pomegranate, he developed refractory anaphylaxis requiring repeated intramuscular administrations of epinephrine and a continuous epinephrine infusion. This case highlights that, despite being an uncommon food allergen, pomegranate can provoke life- threatening systemic reactions in children. Clinicians should be aware of this potential and consider it in the differential diagnosis of unexplained recurrent angioedema or anaphylaxis.
{"title":"Pomegranate-induced refractory anaphylaxis in a toddler","authors":"E. Bahadir, B. Can Duran, S. Demirsöz, C. Aytekin, S. Özmen","doi":"10.1016/j.reval.2025.104640","DOIUrl":"10.1016/j.reval.2025.104640","url":null,"abstract":"<div><div>Pomegranate (Punica granatum) is a fruit rich in antioxidants and commonly consumed worldwide. However, although generally well tolerated, it has rarely been implicated in severe allergic reactions, including anaphylaxis. We report the case of a 3.5-year-old boy with a five-month history of recurrent periorbital angioedema. Careful history revealed pomegranate ingestion preceding one of these episodes. During an oral food challenge with pomegranate, he developed refractory anaphylaxis requiring repeated intramuscular administrations of epinephrine and a continuous epinephrine infusion. This case highlights that, despite being an uncommon food allergen, pomegranate can provoke life- threatening systemic reactions in children. Clinicians should be aware of this potential and consider it in the differential diagnosis of unexplained recurrent angioedema or anaphylaxis.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104640"},"PeriodicalIF":0.3,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-21DOI: 10.1016/j.reval.2025.104623
M. Yildiz , A.C. Genc , E. Zafer , Ö. Özdemir
Study objective
Anaphylaxis is a potentially life-threatening hypersensitivity reaction that requires prompt recognition and immediate intervention. Primary care physicians, often being the first to respond, play a critical role in its management; however, global evidence reveals persistent gaps in their knowledge and practice. This nationwide study aimed to assess the knowledge, clinical practices, and preparedness of primary care physicians in Turkey regarding the management of anaphylaxis.
Methods
A cross-sectional online survey was conducted among 400 active primary care physicians. The questionnaire comprised 8 demographic/practice items and 16 knowledge-based questions aligned with WAO 2020 and EAACI 2021 guidelines. Descriptive and multivariate statistical analyses were applied.
Results
While 86.5% of participants correctly identified epinephrine as the first-line treatment, only 74.0% knew the correct dose, 53.0% the appropriate concentration, and 78.8% the recommended injection site. Regular educational activity and recent training were significantly associated with higher knowledge scores (respectively; P = 0.028 and P = 0.021). Clinical experience alone did not predict better performance. Across all primary care physicians, the mean number of correct answers to the 16 knowledge-based questions was 9.93 ± 2.48. Among subgroups, general practitioners scored significantly lower (8.82 ± 2.60) compared to family medicine residents (10.02 ± 2.36) and family medicine specialists (10.62 ± 2.28) (P < 0.001).
Conclusion
The study reveals substantial knowledge deficiencies among Turkish primary care physicians, especially in epinephrine use (72%). Structured continuing education and integration of anaphylaxis-specific training into primary care physicians’ curricula are urgently needed to improve frontline response and patient safety.
{"title":"Knowledge, practices and preparedness in anaphylaxis management among primary care physicians in Türkiye: A nationwide cross-sectional study","authors":"M. Yildiz , A.C. Genc , E. Zafer , Ö. Özdemir","doi":"10.1016/j.reval.2025.104623","DOIUrl":"10.1016/j.reval.2025.104623","url":null,"abstract":"<div><h3>Study objective</h3><div>Anaphylaxis is a potentially life-threatening hypersensitivity reaction that requires prompt recognition and immediate intervention. Primary care physicians, often being the first to respond, play a critical role in its management; however, global evidence reveals persistent gaps in their knowledge and practice. This nationwide study aimed to assess the knowledge, clinical practices, and preparedness of primary care physicians in Turkey regarding the management of anaphylaxis.</div></div><div><h3>Methods</h3><div>A cross-sectional online survey was conducted among 400 active primary care physicians. The questionnaire comprised 8 demographic/practice items and 16 knowledge-based questions aligned with WAO 2020 and EAACI 2021 guidelines. Descriptive and multivariate statistical analyses were applied.</div></div><div><h3>Results</h3><div>While 86.5% of participants correctly identified epinephrine as the first-line treatment, only 74.0% knew the correct dose, 53.0% the appropriate concentration, and 78.8% the recommended injection site. Regular educational activity and recent training were significantly associated with higher knowledge scores (respectively; <em>P</em> <!-->=<!--> <!-->0.028 and <em>P</em> <!-->=<!--> <!-->0.021). Clinical experience alone did not predict better performance. Across all primary care physicians, the mean number of correct answers to the 16 knowledge-based questions was 9.93<!--> <!-->±<!--> <!-->2.48. Among subgroups, general practitioners scored significantly lower (8.82<!--> <!-->±<!--> <!-->2.60) compared to family medicine residents (10.02<!--> <!-->±<!--> <!-->2.36) and family medicine specialists (10.62<!--> <!-->±<!--> <!-->2.28) (<em>P</em> <!--><<!--> <!-->0.001).</div></div><div><h3>Conclusion</h3><div>The study reveals substantial knowledge deficiencies among Turkish primary care physicians, especially in epinephrine use (72%). Structured continuing education and integration of anaphylaxis-specific training into primary care physicians’ curricula are urgently needed to improve frontline response and patient safety.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104623"},"PeriodicalIF":0.3,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}