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Rôle de la barrière intestinale dans les allergies alimentaires 肠道屏障在食物过敏中的作用
IF 0.3 4区 医学 Pub Date : 2026-01-09 DOI: 10.1016/j.reval.2025.104641
M. Bodinier
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引用次数: 0
Dermatite de contact chronique au Parthenium à l’ère du changement climatique : efficacité de l’azathioprine 气候变化时期帕特尼的慢性接触性皮炎:硫唑嘌呤的有效性
IF 0.3 4区 医学 Pub Date : 2025-12-30 DOI: 10.1016/j.reval.2025.104635
Sofia Gueroum, Fatima-Zahra ElFatoiki, Fouzia Hali, Soumiya Chiheb
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引用次数: 0
Impact de l’intervention d’une conseillère en environnement intérieur à domicile, sur l’évolution de la santé des patients visités – étude rétrospective de onze ans de pratique (2011–2022) 家庭室内环境咨询对患者健康发展的影响——11年实践回顾性研究(2011 - 2022年)
IF 0.3 4区 医学 Pub Date : 2025-12-30 DOI: 10.1016/j.reval.2025.104636
M. Mesbah, S. Martinez, C. Gonzalez, N. Touati Leray
An Indoor Environmental Advisor is a health professional trained to diagnose household environment of patients suffering from respiratory illnesses (mostly allergic asthma). They only intervene with a medical prescription. In order to evaluate the impact of the advisor's intervention on the patient's respiratory illness, a retrospective study was conducted from 2011 to 2022, over 648 house visits, through a form sent 6 months following the visit. In all, 164 forms were analyzed (25% of visited patients). The aim is to show the impact of these visits on the patient's health. Three out of four patients reported a global improvement in their health as well as a decrease in the number of attacks and crisis. For a quarter of patients, the ongoing disease treatment was stopped. Half of the patients are less absent (at work or school) and less often need to consult their physician or to be hospitalized. This declarative retrospective study contains biases but showcases a strong trend (namely health improvements, lower meds consumption, less hospitalizations) which are in agreement with those observed on numerous studies on the medical usefulness of the role of the Indoor Environment Advisor.
室内环境顾问是一名经过培训的健康专业人员,负责诊断患有呼吸系统疾病(主要是过敏性哮喘)的患者的家庭环境。他们只会凭医嘱干预为了评估顾问的干预对患者呼吸道疾病的影响,从2011年到2022年,通过访问6个月后发送的表格,对648次家访进行了回顾性研究。总共分析了164份表格(占访问患者的25%)。目的是显示这些访问对病人健康的影响。四分之三的患者报告说,他们的健康状况总体上有所改善,发作和危机的次数也有所减少。四分之一的患者停止了正在进行的疾病治疗。一半的患者缺勤(上班或上学)减少,需要咨询医生或住院的次数减少。这项声明性回顾性研究存在偏差,但显示出一种强有力的趋势(即健康改善、药物消耗减少、住院次数减少),这与关于室内环境顾问作用的医疗用途的许多研究中观察到的结果一致。
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引用次数: 0
FPIES presenting as intussusception: A rare mimic or a triggered complication? 表现为肠套叠:罕见的模拟或触发并发症?
IF 0.3 4区 医学 Pub Date : 2025-12-30 DOI: 10.1016/j.reval.2025.104624
M. Özer

Introduction

Food protein-induced enterocolitis syndrome (FPIES) is a rare form of non-IgE-mediated food allergy that typically presents in infancy. The clinical picture is usually characterized by delayed-onset, repetitive severe vomiting. Due to these symptoms, FPIES can be easily confused with acute abdominal conditions requiring surgical intervention, such as intussusception, and must therefore be considered in the differential diagnosis.

Case report

A previously healthy six-month-old male infant presented to the emergency department with profuse vomiting and lethargy approximately one hour after ingesting yogurt for the first time. Evaluation revealed intussusception, and surgical intervention was performed. Due to the history of recurrent vomiting and lethargy after yogurt ingestion, FPIES was considered as a preliminary diagnosis. At nine months of age, an open oral food challenge was performed, which confirmed the diagnosis of FPIES.

Conclusion

This case demonstrates that FPIES may not only mimic intussusception but also predispose to this complication. Therefore, FPIES should be considered in the differential diagnosis of infants presenting with gastrointestinal symptoms, and complications such as intussusception should be recognized as potentially associated with FPIES, particularly in cases of persistent vomiting despite ondansetron.
食物蛋白诱导的小肠结肠炎综合征(FPIES)是一种罕见的非ige介导的食物过敏,通常出现在婴儿期。临床表现通常为迟发性反复严重呕吐。由于这些症状,FPIES很容易与需要手术干预的急性腹部疾病(如肠套叠)混淆,因此必须在鉴别诊断中加以考虑。病例报告:一名先前健康的6个月男婴在首次摄入酸奶约1小时后出现大量呕吐和嗜睡。评估显示肠套叠,并进行手术干预。由于酸奶摄入后有反复呕吐和嗜睡的病史,我们认为FPIES是一种初步诊断。在9个月大时,进行了开放的口腔食物挑战,证实了FPIES的诊断。结论本病例表明,fies不仅可能模拟肠套叠,而且易发生该并发症。因此,在以胃肠道症状为表现的婴儿鉴别诊断中,应考虑到FPIES,并且应认识到肠套叠等并发症可能与FPIES有关,特别是在使用昂丹西酮后仍持续呕吐的情况下。
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引用次数: 0
Réintroduction médicamenteuse en allergologie : niveau de confiance et intention de reprise 过敏症药物再引入:信心水平和恢复意图
IF 0.3 4区 医学 Pub Date : 2025-12-26 DOI: 10.1016/j.reval.2025.104618
C. André, C. Bara, H. Maillard

Introduction

Drug provocation tests are gold standard to confirm or exclude drug allergy. Few studies have specifically investigated patients’ adherence after a negative test and the determinants of their level of trust in the procedure. We aimed to assess both the trust level and the intention to resume the reintroduced drugs in adult patients who had completed a full allergology workup, including a negative drug provocation test.

Methods

This retrospective, cross-sectional, observational, descriptive, and analytical study was conducted in the Allergy unit of Le Mans hospital between April and July 2025. It included 305 drug provocation tests with negative outcomes performed in 230 patients reintroduced between 2017 and 2021.

Results

A total of 64.3% of surveyed patients reported a satisfactory trust level (at least 7/10) in the drug provocation tests for a future resumption of the drug. Among our patients, 35.4 % had already resumed the treatment after reintroduction. The mean trust score was 7.02/10, rising to 8.90/10 among “confident” patients who were willing to resume the drug at home. The reintroduction of a corticosteroid or the presence of polyallergy in the patient's record appeared to be the two main factors of reluctance to resume treatment. Forty-four percent of patients did not recall having a written record of the drug provocation test outcome.

Conclusion

We found post-drug provocation test adherence to be consistent with the literature. A specific focus on patients at high risk of non-adherence could improve their level of treatment resumption. Providing a document confirming the absence of allergy, or adding a “drug tested and reintroduced” note to the patient's digital health record, appear to be promising approaches to counter forgetting and/or misreporting to healthcare professionals managing the patient in the future.
药物激发试验是确认或排除药物过敏的金标准。很少有研究专门调查患者在阴性测试后的依从性以及他们对手术信任程度的决定因素。我们的目的是评估成人患者的信任水平和恢复重新引入药物的意愿,这些患者已经完成了完整的过敏学检查,包括药物激发试验阴性。方法回顾性、横断面、观察性、描述性和分析性研究于2025年4月至7月在勒芒医院过敏科进行。它包括在2017年至2021年期间重新引入的230名患者中进行的305次药物激发试验,结果为阴性。结果64.3%的受访患者对药物激发试验表示满意(至少7/10)。在我们的患者中,35.4%的患者在重新引入后已经恢复治疗。平均信任得分为7.02/10,在“自信”的患者中,愿意在家继续服药的人上升到8.90/10。重新引入皮质类固醇或患者记录中存在多重过敏似乎是不愿恢复治疗的两个主要因素。44%的患者不记得有药物激发试验结果的书面记录。结论用药后激发试验依从性与文献一致。对高危不依从性患者的特别关注可以提高他们的治疗恢复水平。提供一份确认没有过敏的文件,或者在患者的数字健康记录中添加“药物测试和重新引入”的注释,似乎是很有希望的方法,可以防止将来向管理患者的医疗保健专业人员遗忘和/或误报。
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引用次数: 0
Désensibilisation au cotrimoxazole chez un nourrisson marocain atteint du syndrome de Wiskott-Aldrich : rapport de cas 患有Wiskott-Aldrich综合征的摩洛哥婴儿对复方恶唑脱敏:病例报告
IF 0.3 4区 医学 Pub Date : 2025-12-24 DOI: 10.1016/j.reval.2025.104637
M. Amaziane , F. Makhloufi , S. Benchekroun , C. Mahraoui , N. El Hafidi

Background

Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency characterized by a classic triad of eczema, recurrent infections and microthrombocytopenia. Opportunistic infections are the leading cause of morbidity and mortality, underscoring the critical importance of cotrimoxazole (CMX) prophylaxis. However, CMX can cause cutaneous hypersensitivity reactions, which are particularly challenging in patients with WAS.

Case presentation

We describe the occurrence of an eczematous rash in an 11-month-old infant with WAS shortly after the initiation of CMX. Since the patient had also received intravenous immunoglobulin and antituberculous therapy, a comprehensive medication timeline was reconstructed in order to identify the causative agent. According to this analysis, the most likely trigger was CMX. In order to maintain prophylaxis, an oral desensitization protocol was subsequently implemented.

Results

Oral desensitization over three days was well tolerated, allowing full target daily dose administration without recurrence of cutaneous reaction and maintaining essential antibiotic prophylaxis.

Conclusion

Oral CMX desensitization is a safe and effective strategy in infants with WAS, for whom therapeutic alternatives are limited. Standardization and dissemination of pediatric desensitization protocols are necessary to improve patient care.
wiskott - aldrich综合征(WAS)是一种罕见的原发性免疫缺陷,以典型的湿疹、复发性感染和微血小板减少症为特征。机会性感染是发病率和死亡率的主要原因,强调了复方新诺明(CMX)预防的至关重要性。然而,CMX可引起皮肤过敏反应,这在WAS患者中尤其具有挑战性。病例介绍:我们描述了一个11个月大的婴儿在CMX开始后不久出现湿疹皮疹。由于患者还接受了静脉免疫球蛋白和抗结核药物治疗,因此重建了一个全面的用药时间表,以确定病原体。根据这一分析,最有可能的触发因素是CMX。为了保持预防,随后实施了口腔脱敏方案。结果3天以上的口腔脱敏耐受良好,可实现每日全靶剂量给药,无皮肤反应复发,并维持必要的抗生素预防。结论口服CMX脱敏治疗婴儿WAS是一种安全有效的治疗策略,治疗方案有限。儿科脱敏方案的标准化和传播对于改善患者护理是必要的。
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引用次数: 0
Importance of neutrophil-lymphocyte, platelet-lymphocyte ratio in urticaria 中性粒细胞-淋巴细胞、血小板-淋巴细胞比例在荨麻疹中的重要性
IF 0.3 4区 医学 Pub Date : 2025-12-24 DOI: 10.1016/j.reval.2025.104620
Öner Özdemir
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引用次数: 0
Pomegranate-induced refractory anaphylaxis in a toddler 蹒跚学步儿童石榴致难治性过敏反应
IF 0.3 4区 医学 Pub Date : 2025-12-24 DOI: 10.1016/j.reval.2025.104640
E. Bahadir, B. Can Duran, S. Demirsöz, C. Aytekin, S. Özmen
Pomegranate (Punica granatum) is a fruit rich in antioxidants and commonly consumed worldwide. However, although generally well tolerated, it has rarely been implicated in severe allergic reactions, including anaphylaxis. We report the case of a 3.5-year-old boy with a five-month history of recurrent periorbital angioedema. Careful history revealed pomegranate ingestion preceding one of these episodes. During an oral food challenge with pomegranate, he developed refractory anaphylaxis requiring repeated intramuscular administrations of epinephrine and a continuous epinephrine infusion. This case highlights that, despite being an uncommon food allergen, pomegranate can provoke life- threatening systemic reactions in children. Clinicians should be aware of this potential and consider it in the differential diagnosis of unexplained recurrent angioedema or anaphylaxis.
石榴(Punica granatum)是一种富含抗氧化剂的水果,在世界范围内普遍食用。然而,尽管通常耐受性良好,但很少涉及严重的过敏反应,包括过敏反应。我们报告一个3.5岁的男孩,有5个月的复发性眼眶周围血管性水肿史。仔细的病史显示,在这些发作之前摄入了石榴。在口服石榴食物挑战期间,他出现了难治性过敏反应,需要反复肌肉注射肾上腺素和持续输注肾上腺素。这个案例强调,尽管石榴是一种不常见的食物过敏原,但它可以引起儿童危及生命的全身反应。临床医生应该意识到这种可能性,并在不明原因复发性血管性水肿或过敏反应的鉴别诊断中加以考虑。
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引用次数: 0
Response to Dr. Özdemir's Letter 回复Özdemir博士的信
IF 0.3 4区 医学 Pub Date : 2025-12-24 DOI: 10.1016/j.reval.2025.104619
S. Çevik , U. Altaş , H. Alkaya , A. Sarısaltık , M.Y. Özkars
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引用次数: 0
Knowledge, practices and preparedness in anaphylaxis management among primary care physicians in Türkiye: A nationwide cross-sectional study <s:1>基耶州初级保健医生过敏反应管理的知识、实践和准备:一项全国性的横断面研究
IF 0.3 4区 医学 Pub Date : 2025-12-21 DOI: 10.1016/j.reval.2025.104623
M. Yildiz , A.C. Genc , E. Zafer , Ö. Özdemir

Study objective

Anaphylaxis is a potentially life-threatening hypersensitivity reaction that requires prompt recognition and immediate intervention. Primary care physicians, often being the first to respond, play a critical role in its management; however, global evidence reveals persistent gaps in their knowledge and practice. This nationwide study aimed to assess the knowledge, clinical practices, and preparedness of primary care physicians in Turkey regarding the management of anaphylaxis.

Methods

A cross-sectional online survey was conducted among 400 active primary care physicians. The questionnaire comprised 8 demographic/practice items and 16 knowledge-based questions aligned with WAO 2020 and EAACI 2021 guidelines. Descriptive and multivariate statistical analyses were applied.

Results

While 86.5% of participants correctly identified epinephrine as the first-line treatment, only 74.0% knew the correct dose, 53.0% the appropriate concentration, and 78.8% the recommended injection site. Regular educational activity and recent training were significantly associated with higher knowledge scores (respectively; P = 0.028 and P = 0.021). Clinical experience alone did not predict better performance. Across all primary care physicians, the mean number of correct answers to the 16 knowledge-based questions was 9.93 ± 2.48. Among subgroups, general practitioners scored significantly lower (8.82 ± 2.60) compared to family medicine residents (10.02 ± 2.36) and family medicine specialists (10.62 ± 2.28) (P < 0.001).

Conclusion

The study reveals substantial knowledge deficiencies among Turkish primary care physicians, especially in epinephrine use (72%). Structured continuing education and integration of anaphylaxis-specific training into primary care physicians’ curricula are urgently needed to improve frontline response and patient safety.
研究目的过敏反应是一种潜在的危及生命的超敏反应,需要及时识别和立即干预。初级保健医生往往是第一个作出反应的,在其管理中起着关键作用;然而,全球证据表明,他们在知识和实践方面存在持续差距。这项全国性的研究旨在评估土耳其初级保健医生关于过敏反应管理的知识、临床实践和准备情况。方法对400名在职初级保健医生进行横断面在线调查。问卷包括8个人口统计/实践项目和16个基于知识的问题,与WAO 2020和EAACI 2021指南保持一致。采用描述性和多变量统计分析。结果86.5%的参与者正确识别肾上腺素为一线治疗药物,但只有74.0%的人知道正确剂量,53.0%的人知道适当浓度,78.8%的人知道推荐注射部位。定期的教育活动和近期的培训与较高的知识得分显著相关(P = 0.028和P = 0.021)。临床经验本身并不能预测更好的表现。在所有初级保健医生中,16个基于知识的问题的平均正确答案数为9.93±2.48。在亚组中,全科医生得分(8.82±2.60)明显低于家庭医学住院医师得分(10.02±2.36)和家庭医学专科医生得分(10.62±2.28)(P < 0.001)。结论:该研究揭示了土耳其初级保健医生的大量知识不足,特别是在肾上腺素使用方面(72%)。迫切需要结构化的继续教育和将过敏反应特异性培训整合到初级保健医生的课程中,以提高一线反应和患者安全。
{"title":"Knowledge, practices and preparedness in anaphylaxis management among primary care physicians in Türkiye: A nationwide cross-sectional study","authors":"M. Yildiz ,&nbsp;A.C. Genc ,&nbsp;E. Zafer ,&nbsp;Ö. Özdemir","doi":"10.1016/j.reval.2025.104623","DOIUrl":"10.1016/j.reval.2025.104623","url":null,"abstract":"<div><h3>Study objective</h3><div>Anaphylaxis is a potentially life-threatening hypersensitivity reaction that requires prompt recognition and immediate intervention. Primary care physicians, often being the first to respond, play a critical role in its management; however, global evidence reveals persistent gaps in their knowledge and practice. This nationwide study aimed to assess the knowledge, clinical practices, and preparedness of primary care physicians in Turkey regarding the management of anaphylaxis.</div></div><div><h3>Methods</h3><div>A cross-sectional online survey was conducted among 400 active primary care physicians. The questionnaire comprised 8 demographic/practice items and 16 knowledge-based questions aligned with WAO 2020 and EAACI 2021 guidelines. Descriptive and multivariate statistical analyses were applied.</div></div><div><h3>Results</h3><div>While 86.5% of participants correctly identified epinephrine as the first-line treatment, only 74.0% knew the correct dose, 53.0% the appropriate concentration, and 78.8% the recommended injection site. Regular educational activity and recent training were significantly associated with higher knowledge scores (respectively; <em>P</em> <!-->=<!--> <!-->0.028 and <em>P</em> <!-->=<!--> <!-->0.021). Clinical experience alone did not predict better performance. Across all primary care physicians, the mean number of correct answers to the 16 knowledge-based questions was 9.93<!--> <!-->±<!--> <!-->2.48. Among subgroups, general practitioners scored significantly lower (8.82<!--> <!-->±<!--> <!-->2.60) compared to family medicine residents (10.02<!--> <!-->±<!--> <!-->2.36) and family medicine specialists (10.62<!--> <!-->±<!--> <!-->2.28) (<em>P</em> <!-->&lt;<!--> <!-->0.001).</div></div><div><h3>Conclusion</h3><div>The study reveals substantial knowledge deficiencies among Turkish primary care physicians, especially in epinephrine use (72%). Structured continuing education and integration of anaphylaxis-specific training into primary care physicians’ curricula are urgently needed to improve frontline response and patient safety.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104623"},"PeriodicalIF":0.3,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Revue Francaise d Allergologie
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