Novel and simple electrochemical sensing platform based on polypyrrole nanotubes/ZIF-67 nanocomposite/screen printed graphite electrode for sensitive determination of metronidazole

IF 4.7 3区工程技术 Q2 ELECTROCHEMISTRY Electrochemistry Communications Pub Date : 2024-10-12 DOI:10.1016/j.elecom.2024.107824

Somayeh Tajik , Hadi Beitollahi , Fariba Garkani Nejad

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Abstract

Here, a simple, fast, and sensitive voltammetric sensor based on screen printed graphite electrode (SPGE) modified with polypyrrole nanotubes/zeolitic imidazolate framework-67 (PPy NTs/ZIF-67) nanocomposite is introduced for the metronidazole (MNZ) determination. The PPy NTs/ZIF-67 nanocomposite was synthesized and characterized by using X-ray diffraction (XRD) spectroscopy, field emission scanning electron microscopy (FE-SEM), and energy-dispersive X-ray spectroscopy (EDS) techniques. The developed sensor based on PPy NTs-ZIF-67 nanocomposite modified SPGE shows an obvious reduction peak at −650 mV for MNZ, mainly due to the synergistic effects of the ZIF-67 and PPy NTs. Differential pulse voltammetry (DPV) was found to be the most suitable method for MNZ detection, showing a linear dynamic range of 0.01–500.0 µM and a low limit of detection (LOD) of 0.004 µM. In investigating the practicability, the PPy NTs/ZIF-67/SPGE sensor demonstrated efficient practicability with satisfactory recoveries (97.1 % to 103.5 %) and low relative standard deviation (RSD) values of 1.8–3.6 % for MNZ determination in MNZ tablets and urine samples.

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基于聚吡咯纳米管/ZIF-67 纳米复合材料/丝网印刷石墨电极的新型简便电化学传感平台，用于灵敏测定甲硝唑

本文介绍了一种基于丝网印刷石墨电极（SPGE）和聚吡咯纳米管/唑基咪唑啉框架-67（PPy NTs/ZIF-67）纳米复合材料修饰的简单、快速、灵敏的伏安传感器，用于甲硝唑（MNZ）的测定。利用 X 射线衍射（XRD）光谱、场发射扫描电子显微镜（FE-SEM）和能量色散 X 射线光谱（EDS）技术合成了 PPy NTs/ZIF-67 纳米复合材料，并对其进行了表征。所开发的基于 PPy NTs-ZIF-67 纳米复合材料修饰的 SPGE 传感器在 -650 mV 处对 MNZ 有明显的还原峰，这主要是由于 ZIF-67 和 PPy NTs 的协同作用。研究发现，差分脉冲伏安法（DPV）是最适合检测 MNZ 的方法，其线性动态范围为 0.01-500.0 µM，检出限（LOD）低至 0.004 µM。在实用性研究中，PPy NTs/ZIF-67/SPGE 传感器在 MNZ 药片和尿样中的 MNZ 检测中表现出高效的实用性，回收率令人满意（97.1 % 至 103.5 %），相对标准偏差 (RSD) 值低至 1.8 % 至 3.6 %。

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来源期刊

Electrochemistry Communications 工程技术-电化学

CiteScore

8.50

自引率

3.70%

发文量

160

审稿时长

1.2 months

期刊介绍： Electrochemistry Communications is an open access journal providing fast dissemination of short communications, full communications and mini reviews covering the whole field of electrochemistry which merit urgent publication. Short communications are limited to a maximum of 20,000 characters (including spaces) while full communications and mini reviews are limited to 25,000 characters (including spaces). Supplementary information is permitted for full communications and mini reviews but not for short communications. We aim to be the fastest journal in electrochemistry for these types of papers.