Mechanistic insights and therapeutic applications of Hinokitiol in Inflammation, Antimicrobial therapy, and Cancer

Abstract

Background

Hinokitiol (β-thujaplicin), a naturally occurring tropolone derivative, exhibits multifaceted pharmacological properties. The aim of this review is to explore the medicinal potential of hinokitiol in different biological systems.

Objectives

To systematically investigate hinokitiol's anti-inflammatory, antimicrobial, and antineoplastic properties; explore its molecular mechanisms of action; determine its toxicological profile; and future research.

Methods

We conducted a search on PubMed, Scopus, and Web of Science for research publications. Initially, we recognized 300 studies. Following a comprehensive analysis, 186 studies reported the pharmacological properties of hinokitiol. We excluded articles that either lacked experimental rigor or provided insufficient mechanistic insight.

Results

Hinokitiol demonstrates significant anti-inflammatory effects through modulation of NF-κB, MAPK, and associated signaling cascades. Its broad-spectrum antimicrobial activity has bactericidal, fungicidal, and antiviral properties, with unique mechanisms of action that may circumvent conventional resistance pathways. Anticancer effects have been observed in multiple neoplastic cell lines and animal models, including breast, lung, endometrial, and hepatocellular carcinomas, mediated through induction of apoptosis, cell cycle arrest, and modulation of autophagic processes. Additional studies indicate antioxidant, neuroprotective, and dermatological benefits. Toxicological assessments suggest favorable tolerability at therapeutic doses, though comprehensive human safety data remain limited.

Conclusions

Hinokitiol shows significant potential for treating infections, inflammation, and cancers by targeting key cellular pathways. However, further research is needed to optimize its dosage, ensure safety, and improve bioavailability for clinical use. While promising, more studies are required to translate its preclinical success into effective therapies.