Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement

Piotr Jachimowski , Łukasz Ciulkiewicz , Bogna Ziarkiewicz-Wróblewska , Laretta Grabowska-Derlatka , Grzegorz Basak , Mateusz Ziarkiewicz
{"title":"Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement","authors":"Piotr Jachimowski ,&nbsp;Łukasz Ciulkiewicz ,&nbsp;Bogna Ziarkiewicz-Wróblewska ,&nbsp;Laretta Grabowska-Derlatka ,&nbsp;Grzegorz Basak ,&nbsp;Mateusz Ziarkiewicz","doi":"10.1016/j.cpccr.2024.100324","DOIUrl":null,"url":null,"abstract":"<div><div>Concomitant chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) in the same patient is extremely rare. In this report, we present an unprecedented case of a patient with a history of progressive, purine analog-resistant CLL, who developed extramedullary malignant plasmacytic infiltrates in lymph nodes on the background of preexisting CLL lesions, presenting with clinical sequelae attributable to active MM (hypercalcemia, renal insufficiency, anemia, bone lesions). We administered R-CHOP with bortezomib with partial remission and both CLL and MM relapsed after one month. Our patient deceased three months later. Surprisingly first bone marrow trephine biopsy did not reveal plasmacytic infiltration. However combination of symptoms presented by our patient should always be an indication for repeating biopsy. Early detection of aggressive multiple myeloma can improve prognosis and prolong survival.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"16 ","pages":"Article 100324"},"PeriodicalIF":0.2000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current problems in cancer. Case reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666621924000474","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Concomitant chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) in the same patient is extremely rare. In this report, we present an unprecedented case of a patient with a history of progressive, purine analog-resistant CLL, who developed extramedullary malignant plasmacytic infiltrates in lymph nodes on the background of preexisting CLL lesions, presenting with clinical sequelae attributable to active MM (hypercalcemia, renal insufficiency, anemia, bone lesions). We administered R-CHOP with bortezomib with partial remission and both CLL and MM relapsed after one month. Our patient deceased three months later. Surprisingly first bone marrow trephine biopsy did not reveal plasmacytic infiltration. However combination of symptoms presented by our patient should always be an indication for repeating biopsy. Early detection of aggressive multiple myeloma can improve prognosis and prolong survival.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
难治性慢性淋巴细胞白血病合并淋巴结受累的髓外多发性骨髓瘤
同一患者同时患有慢性淋巴细胞白血病(CLL)和多发性骨髓瘤(MM)的情况极为罕见。在本报告中,我们发现了一例史无前例的病例,患者曾患有进展性、嘌呤类似物耐药的 CLL,在原有 CLL 病变的背景下,淋巴结出现髓外恶性浆细胞浸润,并伴有活动性 MM 的临床后遗症(高钙血症、肾功能不全、贫血、骨病变)。我们给予硼替佐米联合 R-CHOP 治疗,患者病情部分缓解,但一个月后 CLL 和 MM 均复发。三个月后,我们的病人去世了。令人惊讶的是,第一次骨髓穿刺活检并未发现浆细胞浸润。然而,我们的患者所出现的综合症状始终是重复活检的指征。早期发现侵袭性多发性骨髓瘤可以改善预后,延长生存期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
0.40
自引率
0.00%
发文量
0
审稿时长
96 days
期刊最新文献
Acquired lipodystrophy following use of pembrolizumab Prolonged survival in postoperative recurrent EGFR-L858R NSCLC: A 24-year case report Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement Adeno-squamous carcinoma of bartholin gland: Challenges in diagnosis and management of a less known vulvar cancer – A case report Anaphylaxis from filgrastim prophylaxis within the same day of chemotherapy: A case report
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1