{"title":"Cytotoxic activity properties of a benzimidazolium salt against lung, liver, and colon cancer cell lines","authors":"Senem Akkoc","doi":"10.1016/j.jics.2024.101445","DOIUrl":null,"url":null,"abstract":"<div><div>In this study, a known benzimidazolium salt was synthesized in two steps starting from N-phenyl-<em>o</em>-phenylenediamine. This compound was tested <em>in vitro</em> for 72 h against different cancer cell lines (A549 - lung cancer, HepG2 - liver cancer, DLD-1 - colon cancer) and to compare the activity of this compound with cisplatin, a widely used chemotherapeutic agent. The evaluation of compound <strong>4</strong> as a potential anticancer agent against different cancer types was achieved by examining the cytotoxic effects of this compound through IC50 values using the MTT method. It was found that compound <strong>4</strong> showed different activity depending on the cell type and had a high cytotoxic effect (IC<sub>50</sub>: 15.68 μM), especially against lung cancer cell line for 72 h incubation time.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"101 11","pages":"Article 101445"},"PeriodicalIF":3.2000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Indian Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S001945222400325X","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, a known benzimidazolium salt was synthesized in two steps starting from N-phenyl-o-phenylenediamine. This compound was tested in vitro for 72 h against different cancer cell lines (A549 - lung cancer, HepG2 - liver cancer, DLD-1 - colon cancer) and to compare the activity of this compound with cisplatin, a widely used chemotherapeutic agent. The evaluation of compound 4 as a potential anticancer agent against different cancer types was achieved by examining the cytotoxic effects of this compound through IC50 values using the MTT method. It was found that compound 4 showed different activity depending on the cell type and had a high cytotoxic effect (IC50: 15.68 μM), especially against lung cancer cell line for 72 h incubation time.
期刊介绍:
The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.