Evaluation of auditory system in vitiligo patients: A case-control study

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Clinical Epidemiology and Global Health Pub Date : 2024-10-24 DOI:10.1016/j.cegh.2024.101830

Sima Tajik , Kosar Nazary , Azar Shirzadian Kebria , Keyvan Kiakojori

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Abstract

Background

Vitiligo is a common acquired pigmentary disorder characterized by well-defined areas of depigmentation due to loss of melanocytes. Vitiligo can affect melanocytes in the auditory system and potentially hearing.

Objective

The aim of this study was to investigate hearing changes in vitiligo patients.

Methods

Twenty-six with vitiligo patients and 26 demographically matched healthy controls were included in this study. Audiological function was evaluated using pure tone audiometry (PTA), speech audiometry and tympanometry tests in all subjects.

Results

The mean hearing threshold of the left ear at frequencies of 250 and 8000 Hz in vitiligo patients was significantly higher than the control group. Sensorineural hearing loss (SNHL) was seen in 14 (53.8 %) vitiligo patients and 5(19.2 %) control group (p < 0.05). Most affected patients (10/14; 71 %) had bilateral hearing loss especially in high frequency (8000 Hz). A significant association was identified between vitiligo and SNHL (OR 4.9; 95 % CI, 1.41–16.98, P = 0.01). There was a statistically significant correlation between hearing impairment and age in both groups. Gender, severity, activity and duration of vitiligo had no a significant effect on the results of audiometric tests.

Conclusion

This study confirmed that the auditory system was affected in vitiligo patients. Vitiligo patients might be at a higher risk for auditory abnormalities at a younger age than control subjects. Auditory evaluation of vitiligo patients should be considered for early detection of hearing loss.

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评估白癜风患者的听觉系统：病例对照研究

背景白癜风是一种常见的后天性色素性疾病，其特征是由于黑色素细胞脱失而形成的界限清晰的脱色斑。本研究旨在调查白癜风患者的听力变化。结果白癜风患者左耳在 250 和 8000 Hz 频率下的平均听阈明显高于对照组。14名（53.8%）白癜风患者和5名（19.2%）对照组患者出现感音神经性听力损失（SNHL）（p < 0.05）。大多数患者（10/14；71%）有双侧听力损失，尤其是高频（8000 Hz）。白癜风与SNHL之间存在明显关联（OR 4.9; 95 % CI, 1.41-16.98, P = 0.01）。两组患者的听力损伤与年龄之间存在统计学意义上的显著相关性。性别、白癜风的严重程度、活动和持续时间对听力测试结果没有明显影响。与对照组相比，白癜风患者可能更容易在年轻时出现听觉异常。应考虑对白癜风患者进行听力评估，以便及早发现听力损失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.