{"title":"Urease Inhibition Activity Studies of Novel Azabenzimidazole-Derived Compounds","authors":"G. Akyüz, E. Menteşe","doi":"10.1134/S1070363224090214","DOIUrl":null,"url":null,"abstract":"<p>A new series of azabenzimidazole compounds was synthesized and characterized with spectral methods such as IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and elemental analysis. The target compounds were screened for urease, and acetylcholinesterase inhibitory activities. The synthesized azabenzimidazole containing thiosemicarbazide and oxadiazole moieties showed antiurease activity. 2,2′-[(6-Bromo-2-oxo-1<i>H</i>-imidazo[4,5-<i>b</i>]pyridine-1,3-diyl)bis(1-oxoethane-2,1-diyl)]bis(<i>N</i>-4-nitrophenylhydrazinecarbothioamide) has the best inhibition result with IC<sub>50</sub> = 15.80±0.40 µg/mL (15.75±0.15 µg/mL for thiourea).</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2432 - 2437"},"PeriodicalIF":0.8000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070363224090214","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A new series of azabenzimidazole compounds was synthesized and characterized with spectral methods such as IR, 1H NMR, 13C NMR and elemental analysis. The target compounds were screened for urease, and acetylcholinesterase inhibitory activities. The synthesized azabenzimidazole containing thiosemicarbazide and oxadiazole moieties showed antiurease activity. 2,2′-[(6-Bromo-2-oxo-1H-imidazo[4,5-b]pyridine-1,3-diyl)bis(1-oxoethane-2,1-diyl)]bis(N-4-nitrophenylhydrazinecarbothioamide) has the best inhibition result with IC50 = 15.80±0.40 µg/mL (15.75±0.15 µg/mL for thiourea).
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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