Mg separation from samples with very high Ca/Mg ratios for Mg isotope analysis

Abstract

Samples with very high Ca/Mg ratios present challenges for measuring their Mg isotope ratios. Here, we present an efficient method to separate Mg from samples with high Ca/Mg matrices, which also allows for quantitative separation of Sr, Ca and K. The method comprises a three-step chromatographic separation using DGA and AG50W-X12 (200–400 mesh) cation exchange resin. By utilising the automated sample purification system prepFAST MC™ for two of the three separations, the labour is substantially minimised. This analytical approach results in a quantitative Mg yield and a pure Mg solution, with other cations reduced to below the limit of detection (<53 ng mL⁻¹). We demonstrate the efficacy of this method using a set of geochemical reference materials with Ca/Mg ratios ranging from 1.32 to 1271 mol mol⁻¹. This approach enhances sample throughput and ensures high-quality separations in carbonate samples characterised by high Ca/Mg ratios.