Aging Biomarkers in Assessing the Efficacy of Geroprotective Therapy: Problems and Prospects

IF 0.8 Q3 Engineering Nanotechnologies in Russia Pub Date : 2024-10-29 DOI:10.1134/S2635167624601104

O. Y. Rybina, E. G. Pasyukova

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Abstract

Biomarkers are biological indicators that may be used to evaluate the functional status of an organism, monitor the aging process, and predict the transition of it to a pathological state. Age-related changes in gene expression determine the development of specific age-related phenotypes considered as biomarkers of aging, such as changes in chromatin structure, loss of proteostasis, mitochondrial dysfunction, impaired intercellular communication, chronic inflammation, and imbalances in nutrient uptake. Aging biomarkers are considered to be essential in developing techniques to assess the efficacy of geroprotective treatments. In this context, assessment of the possibility, feasibility, and limitations of the practical use of biomarkers requires a thorough understanding of their molecular nature and careful evidence of their objective association with aging and lifespan. The review considers the data on the effectiveness of the influence of several geroprotectors on aging biomarkers and the lifespan of model organisms and discusses the prospects for using biomarkers of aging to evaluate the efficacy of drug therapy for aging.

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评估老年保护疗法疗效的衰老生物标志物：问题与前景

生物标志物是一种生物指标，可用于评估生物体的功能状态、监测衰老过程并预测其向病理状态的转变。与年龄有关的基因表达变化决定了被视为衰老生物标志物的特定年龄相关表型的发展，如染色质结构变化、蛋白稳态丧失、线粒体功能障碍、细胞间通信受损、慢性炎症和营养摄取失衡。衰老生物标志物被认为是开发老年保护疗法疗效评估技术的关键。在这种情况下，要评估生物标志物实际应用的可能性、可行性和局限性，就必须对其分子性质有透彻的了解，并仔细证明其与衰老和寿命的客观联系。本综述考虑了几种老年保护剂对衰老生物标志物和模式生物寿命的影响效果数据，并讨论了使用衰老生物标志物评估衰老药物疗法疗效的前景。

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Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

1.20

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0.00%

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期刊介绍： Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.