Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo

IF 15.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Advanced drug delivery reviews Pub Date : 2024-10-29 DOI:10.1016/j.addr.2024.115470
Tingting Yu , Xiang Zhong , Dongyu Li , Jingtan Zhu , Valery V. Tuchin , Dan Zhu
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Abstract

Advanced optical imaging provides a powerful tool for the structural and functional analysis of tissues with high resolution and contrast, but the imaging performance decreases as light propagates deeper into the tissue. Tissue optical clearing technique demonstrates an innovative way to realize deep-tissue imaging and have emerged substantially in the last two decades. Here, we briefly reviewed the basic principles of tissue optical clearing techniques in the view of delivery strategies via either free diffusion or external forces-driven advection, and the commonly-used optical techniques for monitoring kinetics of clearing agents in tissue, as well as their ex vivo to in vivo applications in multiple biomedical research fields. With future efforts on the even distribution of both clearing agents and probes, excavation of more effective clearing agents, and automation of tissue clearing processes, tissue optical clearing should provide more insights into the fundamental questions in biological events clinical diagnostics.

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浸泡式光学清除剂在组织中的输送和动力学:从体内到体外的光学成像
先进的光学成像技术为高分辨率和高对比度的组织结构和功能分析提供了强有力的工具,但成像性能会随着光线传播到组织深处而降低。组织光学清除技术是实现深部组织成像的一种创新方法,在过去二十年中得到了长足发展。在此,我们从自由扩散或外力驱动平流的传递策略角度,简要回顾了组织光学清除技术的基本原理,以及用于监测组织中清除剂动力学的常用光学技术及其在多个生物医学研究领域从体内到体外的应用。未来,随着清除剂和探针的均匀分布、更有效清除剂的挖掘以及组织清除过程的自动化,组织光学清除将为生物事件临床诊断中的基本问题提供更多见解。
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来源期刊
CiteScore
28.10
自引率
5.00%
发文量
294
审稿时长
15.1 weeks
期刊介绍: The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.
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