Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing.

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2024-11-13 Epub Date: 2024-10-31 DOI:10.1021/acsami.4c15649

Chen Chen, Fructueux Modeste Amona, Junhao Chen, Xiaohan Chen, Yongding Ke, Shuangcheng Tang, Jinming Xu, Xi Chen, Yipeng Pang

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Abstract

Wound healing is a complex biological process that can trigger inflammation and oxidative stress and impair myofibrillogenesis and angiogenesis. Several advanced wound-dressing nanocomposite materials have been designed to address these issues. Here, we designed a new multifunctional styrene-ethylene-butylene-styrene/silver nanowire (SEBS/AgNWs)-based nanocomposite film with antimicrobial, antioxidant, and anti-inflammatory properties to promote wound healing. The porous morphological structure of SEBS/AgNWs enhances their antimicrobial, antioxidant, and anti-inflammatory properties. SEBS/AgNWs significantly inhibited the growth of Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Escherichia coli strains, effectively wiping out ABTS•+, DPPH•, hydrogen peroxide (H₂O₂), and hydroxyl (•OH) radicals, showing their effective ROS-scavenging properties. It further showed significant antioxidant properties by increasing the levels of enzyme-like catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH), while decreasing malonaldehyde (MDA) levels. Additionally, SEBS/AgNWs reduced the expression of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α), while increasing levels of transforming growth factor- β (TGF-β), vascular endothelial growth factor-A (VEGF), and CD31 in wound healing. This suggests that applying a multifunctional nanoplatform based on SEBS/AgNWs could enhance wound healing and improve patient outcomes in wound care management.

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具有抗菌、抗氧化和抗炎特性的多功能 SEBS/AgNWs 纳米复合薄膜促进感染伤口愈合

伤口愈合是一个复杂的生物过程，可能引发炎症和氧化应激，损害肌纤维生成和血管生成。为了解决这些问题，人们设计了多种先进的伤口敷料纳米复合材料。在此，我们设计了一种新型多功能苯乙烯-乙烯-丁烯-苯乙烯/银纳米线（SEBS/AgNWs）基纳米复合薄膜，具有抗菌、抗氧化和抗炎特性，可促进伤口愈合。SEBS/AgNWs 的多孔形态结构增强了其抗菌、抗氧化和消炎特性。SEBS/AgNWs 能明显抑制金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和大肠杆菌菌株的生长，有效清除 ABTS-+、DPPH-、过氧化氢（H2O2）和羟基（-OH）自由基，显示了其有效清除 ROS 的特性。它还通过提高类过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和谷胱甘肽（GSH）的水平，同时降低丙二醛（MDA）的水平，显示出明显的抗氧化特性。此外，SEBS/AgNWs 还能降低伤口愈合过程中白细胞介素-1β（IL-1β）、IL-6 和肿瘤坏死因子-α（TNF-α）的表达，同时提高转化生长因子-β（TGF-β）、血管内皮生长因子-A（VEGF）和 CD31 的水平。这表明，应用基于 SEBS/AgNWs 的多功能纳米平台可以促进伤口愈合，改善伤口护理管理中患者的治疗效果。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

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