Uniform PtCoRuRhFe high-entropy alloy nanoflowers: Multi-site synergistic signal amplification for colorimetric assay of captopril

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchimica Acta Pub Date : 2024-10-30 DOI:10.1007/s00604-024-06746-x

Rui Zhang, Jia-Qi Li, Ai-Jun Wang, Pei Song, Wen Liu, Jiu-Ju Feng, Tuck Yun Cheang

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Abstract

Uniform PtCoRuRhFe high-entropy alloy nanoflowers (HEANFs) were fabricated by a simple wet-chemical co-reduction method in oleylamine for quantitative colorimetric determination of captopril (CAP) based on multi-site synergistic signal amplification. Specifically, the peroxidase mimetic activity of the PtCoRuRhFe HEANFs was examined through catalysis of 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation, whose catalytic mechanism was investigated by electron paramagnetic resonance (EPR) spectroscopy. The role of the ·O₂⁻ was figured out during the catalytic procedure. Further, the oxidation of TMB (oxTMB) can be effectively reduced by CAP, accompanied by quickly transforming the solution color from blue to colorless. More importantly, the absorbance at 652 nm is linearly related to the CAP concentration in a range 5.0–50.0 mM with a low detection limit of 2.82 mM. The method has been applied to the determination of CAP in human urine samples. It offers a simple and high-efficiency method for facile and visual detection of CAP in hospitals.

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均匀的 PtCoRuRhFe 高熵合金纳米花：卡托普利比色测定的多位点协同信号放大。

在油胺中通过简单的湿化学共还原法制备了均匀的铂钴钌铁高熵合金纳米流（HEANFs），用于基于多位点协同信号放大的卡托普利（CAP）定量比色测定。具体而言，通过催化 3,3',5,5'-四甲基联苯胺（TMB）氧化，考察了 PtCoRuRhFe HEANFs 的过氧化物酶模拟活性，并通过电子顺磁共振（EPR）光谱研究了其催化机理。发现了 -O2- 在催化过程中的作用。此外，CAP 还能有效地还原 TMB 的氧化（oxTMB），并迅速将溶液的颜色从蓝色转变为无色。更重要的是，在 5.0-50.0 mM 范围内，652 nm 处的吸光度与 CAP 浓度呈线性关系，检测限低至 2.82 mM。该方法已应用于人体尿样中 CAP 的检测。该方法简单、高效，可用于医院中 CAP 的快速、直观检测。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.