Yanjun Lu , Mengqi Wang , Yiwen Yang , Qiukai Tang , Yanbo Zeng , Hailong Wang , Lijie Zhang , Chengrui Pan , Changkun Hu , Zhuowei Fu , Lei Li
{"title":"Detecting carcinoembryonic antigen based on the aggregation-induced emission enhancement effect†","authors":"Yanjun Lu , Mengqi Wang , Yiwen Yang , Qiukai Tang , Yanbo Zeng , Hailong Wang , Lijie Zhang , Chengrui Pan , Changkun Hu , Zhuowei Fu , Lei Li","doi":"10.1039/d4cc04544k","DOIUrl":null,"url":null,"abstract":"<div><div>In this study, a novel label-free fluorescent aptasensor with an aggregation-induced emission enhancement effect was developed and applied for the detection of carcinoembryonic antigen (CEA). The sensor has a simple detection mechanism, easy operation, high sensitivity (with low limit of detection of 1 pg mL<sup>−1</sup>), good selectivity, and wide linear range (0.003–10 ng mL<sup>−1</sup>). In addition, it can be directly applied for the determination of CEA in human serum.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"60 92","pages":"Pages 13570-13573"},"PeriodicalIF":4.2000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S135973452402233X","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, a novel label-free fluorescent aptasensor with an aggregation-induced emission enhancement effect was developed and applied for the detection of carcinoembryonic antigen (CEA). The sensor has a simple detection mechanism, easy operation, high sensitivity (with low limit of detection of 1 pg mL−1), good selectivity, and wide linear range (0.003–10 ng mL−1). In addition, it can be directly applied for the determination of CEA in human serum.
期刊介绍:
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