The biological applications of IPN hydrogels.

IF 3.4 Q2 CHEMISTRY, MEDICINAL ADMET and DMPK Pub Date : 2024-08-14 eCollection Date: 2024-01-01 DOI:10.5599/admet.2398
María I León-Campos, Juan J Mendoza, Hilda Aguayo-Morales, Luis E Cobos-Puc, Denis A Cabrera-Munguía, Jesús A Claudio-Rizo
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Abstract

Background and purpose: Interpenetrating polymer network (IPN) hydrogels are an adaptable category of materials, exhibiting remarkable promise for various biological applications due to their distinctive structural and functional attributes. This review delves into the synthesis of IPN hydrogels through both physical and chemical methodologies, elucidating how these techniques allow for precise tailoring of mechanical properties, swelling behaviour, and biocompatibility.

Experimental approach: We conducted an extensive literature review by searching well-established online research databases for articles published since 2009 to gather comprehensive data on IPN hydrogels.

Key results: Our review highlights several critical applications of IPN hydrogels in the biomedical field; i) Tissue engineering: IPN hydrogels are evaluated for their capacity to emulate the extracellular matrix, making them excellent scaffolds for tissue engineering; ii) Controlled drug release: The ability of IPN hydrogels to modulate drug release rates and protect bioactive molecules is explored. Their structure enables sustained and targeted delivery of therapeutic agents, enhancing treatment efficacy; iii) 3D bioprinting: The use of IPN hydrogels as bioinks for 3D bioprinting is assessed, demonstrating their capability to construct intricate, biomimetic structures with high precision; and iv) Regenerative medicine: the development of biomimetic IPN hydrogels for regenerative medicine, emphasizing their potential to closely replicate natural biological environments, thereby promoting effective tissue repair and regeneration.

Conclusion: IPN hydrogels emerge as a versatile and multifaceted platform with significant implications for advancing biomedical science and clinical therapies. Their diverse applications highlight their potential to revolutionize current biomedical practices and contribute to the development of innovative therapeutic solutions.

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IPN 水凝胶的生物应用。
背景和目的:互穿聚合物网络(IPN)水凝胶是一类适应性很强的材料,由于其独特的结构和功能属性,在各种生物应用中展现出广阔的前景。本综述通过物理和化学方法深入探讨 IPN 水凝胶的合成,阐明这些技术如何精确定制机械性能、溶胀行为和生物相容性:实验方法:我们在成熟的在线研究数据库中搜索了 2009 年以来发表的文章,进行了广泛的文献综述,以收集有关 IPN 水凝胶的全面数据:我们的综述突出了 IPN 水凝胶在生物医学领域的几个关键应用:i) 组织工程:IPN水凝胶可模拟细胞外基质,是组织工程的绝佳支架;ii) 可控药物释放:探讨了 IPN 水凝胶调节药物释放速率和保护生物活性分子的能力。IPN 水凝胶的结构可实现治疗剂的持续和定向输送,提高治疗效果;iii) 三维生物打印:评估了 IPN 水凝胶在三维生物打印中作为生物墨水的使用情况,展示了其高精度构建复杂的仿生物结构的能力;以及 iv) 再生医学:开发用于再生医学的仿生物 IPN 水凝胶,强调其密切复制自然生物环境的潜力,从而促进有效的组织修复和再生:IPN 水凝胶是一种多用途、多层面的平台,对推动生物医学科学和临床治疗具有重要意义。IPN 水凝胶的多样化应用彰显了其彻底改变当前生物医学实践的潜力,并有助于开发创新的治疗解决方案。
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来源期刊
ADMET and DMPK
ADMET and DMPK Multiple-
CiteScore
4.40
自引率
0.00%
发文量
22
审稿时长
4 weeks
期刊介绍: ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study
期刊最新文献
Determination of methotrexate using carbon paste electrode modified with ionic liquid/Ni-Co layered double hydroxide nanosheets as a voltammetric sensor. Food and bile micelle binding of zwitterionic antihistamine drugs. Cerium oxide nanoparticles-assisted aptasensor for chronic myeloid leukaemia detection. The biological applications of IPN hydrogels. Investigation of magnesium aluminometasilicate (Neusilin US2) based surface solid dispersion of sorafenib tosylate using QbD approach: In vitro and in vivo pharmacokinetic study
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