Measurement of Healthy Adult Brain Temperature Using ¹H Magnetic Resonance Spectroscopy Thermometry.

IF 2.8 3区医学 Q2 Medicine Clinical Neuroradiology Pub Date : 2024-10-30 DOI:10.1007/s00062-024-01467-3

Yahong Tan, Wenjia Liu, Yanhua Li, Nan Zhang, Mingxiao Wang, Shuo Sun, Lin Ma

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Abstract

Purpose: The purpose of this study is to measure the brain temperature (T_br) by using ¹H magnetic resonance spectroscopy (¹H MRS) thermometry and investigate its age and gender differences in healthy adults. The brain temperature was further compared with the body temperature (T_bo) to investigate the possible existence of brain-body temperature gradient (∆T).

Methods: A total of 80 subjects were included in this study. ¹H MRS data were collected on a 3.0T MR scanner using Point Resolved Selective Spectroscopy (PRESS) sequence. Voxels were positioned in the right frontal (RF) lobe and left frontal (LF) lobe, respectively. The temperature of each voxel was calculated by chemical shift difference (∆δ) between H₂O and NAA which was obtained by LCModel software. The average temperature of bilateral frontal lobe voxels was defined as T_br for each subject. The average forehead temperature was acquired before MR scanning, defined as T_bo, in this study. The difference between T_br and T_bo, denoted as the brain-body temperature gradient (∆T), was calculated. Age and gender characteristics of T_br, ∆T and T_bo were analyzed.

Results: T_br (38.51 ± 0.59℃) was higher than T_bo (36.47 ± 0.26℃) (P < 0.05). Negative correlations were observed between T_br and age (r = -0.49, P < 0.05) and between ∆T and age (r = -0.44, P < 0.05), whereas no correlation existed between T_bo and age (r = -0.03, P = 0.79).

Conclusion: Our observation demonstrated that the brain temperature, derived from ¹H MRS thermometry, is significantly higher than the body temperature, indicating the existence of a brain-body temperature gradient, and the brain temperature gradually decreases with age.

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利用 1H 磁共振波谱温度计测量健康成年人的脑温

目的：本研究旨在利用1H磁共振波谱（1H MRS）测温法测量健康成年人的脑温（Tbr），并研究其年龄和性别差异。将脑温与体温（Tbo）进一步比较，以研究可能存在的脑-体温度梯度（∆T）：本研究共纳入 80 名受试者。在 3.0T 磁共振扫描仪上使用点分辨选择性光谱（PRESS）序列收集 1H MRS 数据。体素分别位于右额叶（RF）和左额叶（LF）。每个体素的温度是通过 LCModel 软件获得的 H2O 和 NAA 化学位移差（Δδ）计算得出的。每个受试者双侧额叶体素的平均温度定义为 Tbr。在本研究中，前额的平均温度是在磁共振扫描前获得的，定义为 Tbo。计算 Tbr 和 Tbo 之间的差值，即脑-体温度梯度（∆T）。分析了 Tbr、∆T 和 Tbo 的年龄和性别特征：结果：Tbr（38.51 ± 0.59℃）高于 Tbo（36.47 ± 0.26℃）（P br 和年龄（r = -0.49，P bo 和年龄（r = -0.03，P = 0.79））：我们的观察结果表明，通过 1H MRS 测温得出的脑温明显高于体温，表明存在脑-体温度梯度，且脑温随着年龄的增长而逐渐降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuroradiology Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

4.90

自引率

3.60%

发文量

期刊介绍： Clinical Neuroradiology provides current information, original contributions, and reviews in the field of neuroradiology. An interdisciplinary approach is accomplished by diagnostic and therapeutic contributions related to associated subjects. The international coverage and relevance of the journal is underlined by its being the official journal of the German, Swiss, and Austrian Societies of Neuroradiology.