Regenerative Skincare Technologies Derived From Human Fibroblasts: Growth Factors and Exosomes for Transformative Outcomes.

IF 2.5 3区 医学 Q2 DERMATOLOGY Dermatologic Surgery Pub Date : 2024-11-01 DOI:10.1097/DSS.0000000000004436
Tsing Cheng, Gail K Naughton, Elizabeth T Makino, Kuniko Kadoya, Prithwiraj Maitra
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Abstract

Background: Since the early 2000s, human fibroblast conditioned media (HFCM) has been used in topical growth factor skincare to support skin regeneration and skin rejuvenation. Human fibroblast conditioned media contains the fibroblast secretome including growth factors as well as exosomes. The potential benefits of topically applied exosomes are gaining interest in the medical aesthetic field.

Objective: This article aims to summarize the preclinical and clinical data available on regenerative HFCM-based topical skincare with a focus on studies investigating products applied to improve overall facial skin rejuvenation and/or after in-office cosmetic procedures. In addition, available data on fibroblast-derived exosomes will be covered.

Methods: A focused literature review was conducted to provide an overview of evidence on HFCM-based topical skincare.

Results: Human fibroblast conditioned media-based skincare significantly reduces signs of skin aging including photodamage, coarse lines and wrinkles, and sagging. After in-office cosmetic procedures, HFCM-based skincare can stimulate skin recovery and reduce downtime as well as provide skin quality benefits to enhance overall treatment outcomes. Application of purified exosomes from HFCM also demonstrated significant improvements in multiple skin aging parameters.

Conclusion: Human fibroblast conditioned media combines naturally secreted fibroblast-derived growth factors and exosomes that stimulate skin regeneration and rejuvenation as evidenced by a variety of assays and assessments including in vitro preclinical studies, clinical investigator grading, instrumentation measurements, biopsy analyses, and patient-reported outcomes.

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源自人类成纤维细胞的再生护肤技术:生长因子和外泌体的变革性成果。
背景:自 2000 年代初以来,人成纤维细胞条件培养基(HFCM)一直被用于局部生长因子护肤,以支持皮肤再生和皮肤年轻化。人成纤维细胞条件培养基含有成纤维细胞分泌组,包括生长因子和外泌体。医学美容领域对外泌体的潜在益处越来越感兴趣:本文旨在总结基于再生高频外泌体的局部护肤品的临床前和临床数据,重点研究用于改善整体面部皮肤年轻化和/或诊所美容手术后的产品。此外,还将涵盖有关成纤维细胞外泌体的现有数据:方法:进行重点文献综述,概述基于 HFCM 的局部护肤品的证据:结果:基于人成纤维细胞条件培养基的护肤品能明显减少皮肤老化迹象,包括光损伤、粗纹、皱纹和松弛。在诊室进行美容手术后,基于 HFCM 的护肤品可刺激皮肤恢复,减少停工期,并为皮肤质量带来益处,从而提高整体治疗效果。应用纯化的 HFCM 外泌体还能显著改善多种皮肤老化参数:结论:人成纤维细胞条件培养基结合了天然分泌的成纤维细胞生长因子和外泌体,可刺激皮肤再生和年轻化,体外临床前研究、临床研究人员分级、仪器测量、活检分析和患者报告结果等各种检测和评估都证明了这一点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Dermatologic Surgery
Dermatologic Surgery 医学-皮肤病学
CiteScore
3.10
自引率
16.70%
发文量
547
期刊介绍: Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.
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