Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study.

IF 4.5 2区医学 Q2 GERIATRICS & GERONTOLOGY Frontiers in Aging Neuroscience Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI:10.3389/fnagi.2024.1437587

Shizhe Zhu, Qinglei Wang, Chaojie Kan, Ayan Geng, Youxin Sui, Ren Zhuang, Yi Zhu, Tong Wang, Lan Zhu, Chuan Guo

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Abstract

Background: The n-back task is a widely used paradigm to assess working memory and is commonly applied in research on age-related cognitive decline. However, studies utilizing functional near-infrared spectroscopy (fNIRS) to explore this area are limited.

Objective: This study aims to investigate age-related differences in brain activation during the n-back task using fNIRS.

Methods: fNIRS data were collected from 18 elderly and 19 young participants while performing different n-back tasks. Brain activation patterns and peripheral performance were compared between the two groups.

Results: Significant differences in brain activation patterns were observed between elderly and young participants. Under the 3-back condition, the older group exhibited reduced activation in brain regions adjacent to prefrontal cognitive areas compared to the younger group. Additionally, the older group's performance plateaued at the 2-back level, along with a decline in prefrontal activation.

Conclusion: These findings may suggest potential markers for cognitive decline, providing a new target for future screening.

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不同 n-back 任务中与年龄相关的大脑变化：功能性近红外光谱研究。

背景：n-back任务是一种广泛用于评估工作记忆的范式，通常应用于与年龄相关的认知能力下降的研究中。然而，利用功能性近红外光谱（fNIRS）来探索这一领域的研究还很有限：本研究旨在利用 fNIRS 研究 n-back 任务中与年龄相关的大脑激活差异。方法：收集了 18 名老年人和 19 名年轻人在执行不同 n-back 任务时的 fNIRS 数据。对两组参与者的大脑激活模式和外周表现进行比较：结果：老年人和年轻人的大脑激活模式存在显著差异。与年轻组相比，老年组在 3 个后退条件下，前额叶认知区邻近脑区的激活减少。此外，老年组的表现在2-back条件下趋于平稳，前额叶激活也有所下降：这些发现可能是认知能力下降的潜在标志，为未来的筛查提供了新的目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.