Forecasting Epidemic Spread with Recurrent Graph Gate Fusion Transformers.

IF 6.7 2区 医学 Q1 COMPUTER SCIENCE, INFORMATION SYSTEMS IEEE Journal of Biomedical and Health Informatics Pub Date : 2024-10-30 DOI:10.1109/JBHI.2024.3488274
Minkyoung Kim, Jae Heon Kim, Beakcheol Jang
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Abstract

Predicting the unprecedented, nonlinear nature of COVID-19 presents a significant public health challenge. Recent advances in deep learning, such as Graph Neural Networks, Recurrent Neural Networks (RNNs), and Transformers, have enhanced predictions by modeling regional interactions, managing autoregressive time series, and identifying long-term dependencies. However, prior works often feature shallow integration of these models, leading to simplistic graph embeddings and inadequate analysis across different graph types. Additionally, excessive reliance on historical COVID-19 data limits the potential of utilizing time-lagged data, such as intervention policy information. To address these challenges, we introduce ReGraFT, a novel Sequence-to-Sequence model designed for robust long-term forecasting of COVID-19. ReGraFT integrates Multigraph-Gated Recurrent Units (MGRUs) with adaptive graphs, leveraging data from individual states, including infection rates, policy changes, and interstate travel. First, ReGraFT employs adaptive MGRU cells within an RNN framework to capture inter-regional dependencies, dynamically modeling complex transmission dynamics. Second, the model features a Self-Normalizing Priming layer using SELUs to enhance stability and accuracy across short, medium, and long-term forecasts. Lastly, ReGraFT systematically compares and integrates various graph types derived from fully connected layers, pooling, and attention-based mechanisms to provide a nuanced representation of inter-regional relationships. By incorporating lagged COVID-19 policy data, ReGraFT refines forecasts, demonstrating RMSE reductions of 2.39-35.92% compared to state-of-the-art models. This work provides accurate long-term predictions, aiding in better public health decisions. Our code is available at https://github.com/mfriendly/ReGraFT.

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利用递归图门融合变换器预测流行病的传播。
COVID-19 具有前所未有的非线性特性,对其进行预测是一项重大的公共卫生挑战。图神经网络(Graph Neural Networks)、递归神经网络(Recurrent Neural Networks,RNNs)和变形器(Transformers)等深度学习领域的最新进展,通过模拟区域相互作用、管理自回归时间序列和识别长期依赖关系,增强了预测能力。然而,之前的研究往往对这些模型的整合较浅,导致图嵌入简单化,对不同图类型的分析不足。此外,对 COVID-19 历史数据的过度依赖限制了利用时滞数据(如干预政策信息)的潜力。为了应对这些挑战,我们引入了 ReGraFT,这是一种新颖的序列到序列模型,旨在对 COVID-19 进行稳健的长期预测。ReGraFT 利用各州的数据(包括感染率、政策变化和州际旅行)将多图关联循环单元 (MGRU) 与自适应图整合在一起。首先,ReGraFT 在 RNN 框架内采用自适应 MGRU 单元来捕捉区域间的依赖关系,动态模拟复杂的传播动态。其次,该模型采用 SELU 自归一化引物层,以提高短期、中期和长期预测的稳定性和准确性。最后,ReGraFT 系统地比较和整合了从全连接层、池化和基于注意力的机制中得出的各种图形类型,以提供区域间关系的细微表示。通过纳入滞后的 COVID-19 政策数据,ReGraFT 完善了预测,与最先进的模型相比,RMSE 降低了 2.39-35.92%。这项工作提供了准确的长期预测,有助于做出更好的公共卫生决策。我们的代码见 https://github.com/mfriendly/ReGraFT。
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来源期刊
IEEE Journal of Biomedical and Health Informatics
IEEE Journal of Biomedical and Health Informatics COMPUTER SCIENCE, INFORMATION SYSTEMS-COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
CiteScore
13.60
自引率
6.50%
发文量
1151
期刊介绍: IEEE Journal of Biomedical and Health Informatics publishes original papers presenting recent advances where information and communication technologies intersect with health, healthcare, life sciences, and biomedicine. Topics include acquisition, transmission, storage, retrieval, management, and analysis of biomedical and health information. The journal covers applications of information technologies in healthcare, patient monitoring, preventive care, early disease diagnosis, therapy discovery, and personalized treatment protocols. It explores electronic medical and health records, clinical information systems, decision support systems, medical and biological imaging informatics, wearable systems, body area/sensor networks, and more. Integration-related topics like interoperability, evidence-based medicine, and secure patient data are also addressed.
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