An Update on Recent Drug Delivery Systems Targeting Brain Diseases via the Transnasal Pathway.

IF 3.5 3区医学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pharmaceutical Research Pub Date : 2024-10-30 DOI:10.1007/s11095-024-03790-3

Huiying Zeng, Huangjie Lu, Jie Yang, Ping Hu

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Abstract

Objective: To explore the potential of transnasal drug delivery systems (DDS) as an effective means of bypassing the bloodbrain barrier (BBB) for enhanced central nervous system (CNS) targeting, aiming to improve therapeutic outcomes for CNS disorders while reducing systemic side effects.

Methods: A review of current and emerging DDS technologies, including polymer nanoparticles, liposomes, and micelles, was conducted to assess their suitability for precision-targeted delivery to the brain through the transnasal route.

Results: The investigated DDS demonstrate promising capabilities for CNS targeting via the nasal pathway, effectively preserving both the nasal mucosa and CNS integrity. These systems enhance drug precision within neural tissues, potentially improving therapeutic outcomes without harming adjacent tissues.

Conclusions: Transnasal DDS offer a promising alternative to traditional delivery methods, with significant potential to advance the treatment of cerebrovascular diseases, neurodegenerative disorders, brain tumors, and psychiatric conditions. This approach represents an evolving frontier in neurotherapeutics, with the potential to transform CNS drug delivery practices.

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经鼻途径治疗脑部疾病的最新药物输送系统。

目的探索经鼻给药系统（DDS）作为绕过血脑屏障（BBB）增强中枢神经系统（CNS）靶向性的有效手段的潜力，旨在改善中枢神经系统疾病的治疗效果，同时减少全身副作用：方法：对当前和新兴的 DDS 技术（包括聚合物纳米颗粒、脂质体和胶束）进行了综述，以评估它们是否适合通过经鼻途径向大脑进行精确靶向递送：结果：所研究的 DDS 展示了通过鼻腔途径靶向中枢神经系统的良好能力，有效地保护了鼻粘膜和中枢神经系统的完整性。这些系统提高了神经组织内的药物精确度，有可能在不损害邻近组织的情况下改善治疗效果：经鼻 DDS 为传统给药方法提供了一种前景广阔的替代方法，在推动脑血管疾病、神经退行性疾病、脑肿瘤和精神疾病的治疗方面潜力巨大。这种方法代表了神经治疗学不断发展的前沿，有可能改变中枢神经系统给药方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical Research 医学-化学综合

CiteScore

6.60

自引率

5.40%

发文量

276

审稿时长

3.4 months

期刊介绍： Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists, is committed to publishing novel research that is mechanism-based, hypothesis-driven and addresses significant issues in drug discovery, development and regulation. Current areas of interest include, but are not limited to: -(pre)formulation engineering and processing- computational biopharmaceutics- drug delivery and targeting- molecular biopharmaceutics and drug disposition (including cellular and molecular pharmacology)- pharmacokinetics, pharmacodynamics and pharmacogenetics. Research may involve nonclinical and clinical studies, and utilize both in vitro and in vivo approaches. Studies on small drug molecules, pharmaceutical solid materials (including biomaterials, polymers and nanoparticles) biotechnology products (including genes, peptides, proteins and vaccines), and genetically engineered cells are welcome.