Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.

IF 3.6 Q2 GENETICS & HEREDITY HGG Advances Pub Date : 2025-01-09 Epub Date: 2024-10-29 DOI:10.1016/j.xhgg.2024.100376

Hridya Rao, Margaret C Weiss, Jee Young Moon, Krista M Perreira, Martha L Daviglus, Robert Kaplan, Kari E North, Maria Argos, Lindsay Fernández-Rhodes, Tamar Sofer

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Abstract

The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study's inception in 2008, as a result of the study's robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.

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西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）在基因研究方面取得的进展：十年回顾

西班牙裔社区健康研究/拉美裔研究（HCHS/SOL）是一项多中心纵向队列研究，旨在评估环境、生活方式和遗传风险因素与美国西班牙裔/拉美裔人群的心脏代谢疾病和其他慢性疾病的关系。自 2008 年该研究启动以来，由于该研究采用了强有力的遗传测量方法，HCHS/SOL 为遗传研究领域做出了重大贡献。这篇 15 年回顾性文章重点介绍了 HCHS/SOL 在基因型表型关系方面的主要发现和统计方法方面的进步。此外，我们还讨论了遗传研究在伦理和社会方面所面临的挑战，尤其是在美国的西班牙裔/拉美裔成年人中。通过 HCHS/SOL 继续开展遗传研究、扩大辅助研究和联盟合作，将进一步推动人类遗传学研究的知识和进步。

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