Exposures to great Chinese Famine during embryo, foetal or infant stages link differently with risks of cardiovascular diseases in late middle age.

IF 2.4 Q3 NUTRITION & DIETETICS Journal of Nutritional Science Pub Date : 2024-10-28 eCollection Date: 2024-01-01 DOI:10.1017/jns.2024.57
Xiuwen Zhou, Yumeng Zhang, Qiutong Zheng, Yi Ding, Daiyi Zhang, Jianhong Pu, Zhice Xu
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Abstract

Perinatal malnutrition is a critical cause of diseases in offspring. Based on the different rates of organ development, we hypothesised that malnutrition at varying early life stages would have a differential impact on cardiovascular disease in middle-aged and older adults. This study sought to assess the long-term impact of exposure to the 1959-1961 Great Chinese Famine (GCF) during early developmental periods on risks of cardiovascular diseases in the late middle-aged offspring. A total 6, 662 individuals, born between 1958 and 1964, were divided into six groups according to the birth date. The generalised line model was used to control age and estimate differences with 95% confidence interval (CI) in blood pressure. Binary logistic regression was applied to evaluate the association between famine exposure and cardiovascular diseases. Compared to the unexposed late middle-aged persons, blood pressure was elevated in the entire gestation exposure group, regardless of postnatal exposure to GCF. Increased blood pressure was also found in the female offspring exposed to GCF during early and middle gestation. The early-childhood exposure was associated with the risk of bradycardia in the offspring. The risks of vertebral artery atherosclerosis were elevated in GCF famine-exposed groups except first trimester exposed group. The chronic influence of GCF in early life periods was specific to the developmental timing window, sexesand organs, suggesting an essential role of interactions among multiple factors and prenatal malnutrition in developmentally "programming" cardiovascular diseases.

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胚胎期、胎儿期或婴儿期接触中国大饥荒与中年后期罹患心血管疾病的风险有着不同的联系。
围产期营养不良是导致后代患病的重要原因。根据器官发育的不同速度,我们假设不同生命早期阶段的营养不良会对中老年人的心血管疾病产生不同的影响。本研究旨在评估1959-1961年中国大饥荒对中年晚期后代心血管疾病风险的长期影响。本研究根据出生日期将 1958 至 1964 年间出生的 6 662 人分为六组。采用广义线性模型控制年龄,并估算血压差异的 95% 置信区间 (CI)。二元逻辑回归用于评估饥荒暴露与心血管疾病之间的关系。与未接触过饥荒的中年后期人群相比,无论出生后是否接触过 GCF,整个妊娠期接触组的血压均升高。在妊娠早期和中期暴露于 GCF 的女性后代中也发现血压升高。儿童早期接触与后代心动过缓的风险有关。除孕期前三个月暴露组外,其他暴露于 GCF 饥荒的组别发生椎动脉粥样硬化的风险均升高。GCF在生命早期的慢性影响与发育时间窗、性别和器官有关,这表明多种因素和产前营养不良在心血管疾病的发育 "编程 "中发挥着重要作用。
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来源期刊
Journal of Nutritional Science
Journal of Nutritional Science NUTRITION & DIETETICS-
CiteScore
3.00
自引率
0.00%
发文量
91
审稿时长
7 weeks
期刊介绍: Journal of Nutritional Science is an international, peer-reviewed, online only, open access journal that welcomes high-quality research articles in all aspects of nutrition. The underlying aim of all work should be, as far as possible, to develop nutritional concepts. JNS encompasses the full spectrum of nutritional science including public health nutrition, epidemiology, dietary surveys, nutritional requirements, metabolic studies, body composition, energetics, appetite, obesity, ageing, endocrinology, immunology, neuroscience, microbiology, genetics, molecular and cellular biology and nutrigenomics. JNS welcomes Primary Research Papers, Brief Reports, Review Articles, Systematic Reviews, Workshop Reports, Letters to the Editor and Obituaries.
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