Systemic and local lipid adaptations underlie regeneration in Drosophila melanogaster and Ambystoma mexicanum.

IF 6.4 1区 医学 Q1 CELL & TISSUE ENGINEERING npj Regenerative Medicine Pub Date : 2024-10-29 DOI:10.1038/s41536-024-00375-x
Ines C Kübler, Jenny Kretzschmar, Maria Nieves Arredondo-Lasso, Sean D Keeley, Luca Claudia Rößler, Katharina Ganss, Tatiana Sandoval-Guzmán, Marko Brankatschk
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Abstract

In regenerating tissues, synthesis and remodeling of membranes rely on lipid turnover and transport. Our study addresses lipid adaptations in intestinal regeneration of Drosophila melanogaster and limb regeneration of Ambystoma mexicanum. We found changes in lipid profiles at different locations: transport, storage organs and regenerating tissues. We demonstrate that attenuating insulin signaling, exclusively in fat storage, inhibits the regeneration-specific response in both the fat storage and the regenerating tissue in Drosophila. Furthermore, in uninjured axolotls we found sex-specific lipid profiles in both storage and circulation, while in regenerating animals these differences subside. The regenerating limb presents a unique sterol profile, albeit with no sex differences. We postulate that regeneration triggers a systemic response, where organs storing lipids play a significant role in the regulation of systemic lipid traffic. Second, that this response may be an active and well-regulated mechanism, as observed when homeostatic sex-differences disappear in regenerating salamanders.

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黑腹果蝇和墨西哥巨蜥再生的系统和局部脂质适应性基础
在再生组织中,膜的合成和重塑依赖于脂质的周转和运输。我们的研究探讨了黑色果蝇肠道再生和墨西哥野马肢体再生过程中的脂质适应性。我们发现不同部位的脂质特征发生了变化:运输、储存器官和再生组织。我们证明,减弱胰岛素信号传导(仅在脂肪储存中)可抑制果蝇脂肪储存和再生组织中的再生特异性反应。此外,在未受伤的轴龙体内,我们发现脂肪储存和循环中都存在性别特异性脂质分布,而在再生动物体内,这些差异逐渐消失。再生的肢体呈现出独特的固醇特征,尽管没有性别差异。我们推测,再生引发了一种系统性反应,在这种反应中,储存脂质的器官在调节系统性脂质运输中发挥了重要作用。其次,这种反应可能是一种活跃的、调节良好的机制,正如在再生蝾螈体内的性别差异消失时观察到的那样。
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来源期刊
npj Regenerative Medicine
npj Regenerative Medicine Engineering-Biomedical Engineering
CiteScore
10.00
自引率
1.40%
发文量
71
审稿时长
12 weeks
期刊介绍: Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.
期刊最新文献
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