Quality of Life after Open Extremity Trauma (QUINTET) study: An international, multicentric, observational, cohort study of quality of life following lower extremity open fractures

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Abstract

Introduction

Open lower limb fractures are severe injuries with long-lasting consequences. Limited research has been conducted on the impact of these injuries on quality of life (QoL), internationally.

Methods

The Quality of Life after Open Extremity Trauma (QUINTET) study was designed as an international, multicentric, observational, cohort study of patients presented with open lower limb fractures. Demographic and clinical information was collected, along with repeated validated QoL measures. Primary outcomes were SF-12 and EQ-5D-3L, and secondary outcomes were soft tissue infection, deep infection, non-union and amputation.

Results

A total of 92 patients were enrolled in 8 centres, based in the UK, Spain, Chile and Sudan. The mean age at presentation was 54 years, 47 years for males and 64 years for females. Males presented a higher proportion of road traffic accidents as the underlying mechanism, whereas for females, this was the case of low-energy falls. Participant retention was 71.7% and 73.9% for the 3- and 12-month assessments, respectively. There was a substantial reduction in QoL after open fracture, which only partially recovered at 12 months. Participants recruited in the UK presented lower QoL scores compared with patients treated in Spain and Chile.

Discussion

For this study, international patient recruitment proved challenging, leading to most patients being recruited in the UK. Despite this limitation, we found a statistically significant detriment in self-reported QoL, which did not recover after a year. This study highlights differences in quality-of-life outcomes from a gender and international perspective.
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开放性四肢创伤后生活质量(QUINTET)研究:一项关于下肢开放性骨折后生活质量的国际性、多中心、观察性、队列研究。
简介开放性下肢骨折是一种严重的损伤,会造成长期的后果。目前,国际上关于这些损伤对生活质量(QoL)影响的研究十分有限:开放性四肢创伤后生活质量(QUINTET)研究是一项国际性、多中心、观察性、队列研究,研究对象为开放性下肢骨折患者。该研究收集了患者的人口统计学和临床信息,并反复采用了经过验证的 QoL 测量方法。主要结果为 SF-12 和 EQ-5D-3L,次要结果为软组织感染、深部感染、不愈合和截肢:英国、西班牙、智利和苏丹的 8 个中心共招募了 92 名患者。患者的平均年龄为 54 岁,其中男性 47 岁,女性 64 岁。男性以道路交通事故为根本原因的比例较高,而女性则以低能量跌倒为根本原因。在 3 个月和 12 个月的评估中,参与者的保留率分别为 71.7% 和 73.9%。开放性骨折后,患者的生活质量大幅下降,12个月后才部分恢复。与在西班牙和智利接受治疗的患者相比,在英国招募的参与者的 QoL 分数较低:讨论:在这项研究中,国际患者招募具有挑战性,导致大多数患者在英国招募。尽管存在这一局限性,但我们发现自我报告的 QoL 在统计学上有显著下降,一年后仍未恢复。这项研究从性别和国际角度强调了生活质量结果的差异。
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来源期刊
CiteScore
3.10
自引率
11.10%
发文量
578
审稿时长
3.5 months
期刊介绍: JPRAS An International Journal of Surgical Reconstruction is one of the world''s leading international journals, covering all the reconstructive and aesthetic aspects of plastic surgery. The journal presents the latest surgical procedures with audit and outcome studies of new and established techniques in plastic surgery including: cleft lip and palate and other heads and neck surgery, hand surgery, lower limb trauma, burns, skin cancer, breast surgery and aesthetic surgery.
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