{"title":"Design of deep eutectic solvents modified palygorskite for selective recognition, mechanism study and stable preservation of quercetin","authors":"","doi":"10.1016/j.clay.2024.107621","DOIUrl":null,"url":null,"abstract":"<div><div>Considering the effect of secondary metabolites on quercetin (QC) separation and purification in plants, herein, four types of hydrophilic deep eutectic solvents (DESs) composed by organic acids and glycosyl-, quaternary ammonium- or alcohol-based hydrogen bond acceptors were designed and modified on the palygoskite (Pal) surface to improve the selectivity of QC via dispersive solid-phase extraction (D-SPE). The selectivity study followed the following order: Pal- [Choline chloride (ChCl)] [Levulinic acid (Lev)] > Pal- [Glycerol (Gly)] [L-Proline (Pro)] > Pal- [Glucose (Glu)] [D-lactic acid (Lac)] > Pal- [Benzyl triethyl ammonium chloride (BTBAC)] [D-lactic acid (Lac)]. Based on the single-factor method, Response surface methodology (RSM) by using a Box-Behnken design (BBD) was applied to assess the mutual interactions and effects between the three factors and the optimized preparation conditions. The optimal nanoparticles (Pal- [ChCl] [Lev]) showed the best adsorption capacity for QC (29.81 mg/g) in the mixture of methanol and phosphate buffered solution (PBS) and high selectivity which was 1.95 times and 2.12 times that of luteolin and rutin hydrate, respectively. Mechanism exploration indicated that Pal-DESs selectively adsorbed QC via electrostatic interaction, π-π stacking and hydrogen bonds. Furthermore, the screened DES of ([ChCl] [Lev]) could act on QC aqueous solution to improve its solubility and stability during preservation. The proposed QC separation strategy centered on the guiding role of DESs in selective adsorption. Additional alternatives for the synthesis of high-efficiency and hydrophilic functional adsorbents for flavonoids were made available by this green DESs regulation concept.</div></div>","PeriodicalId":245,"journal":{"name":"Applied Clay Science","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Clay Science","FirstCategoryId":"89","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0169131724003697","RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Considering the effect of secondary metabolites on quercetin (QC) separation and purification in plants, herein, four types of hydrophilic deep eutectic solvents (DESs) composed by organic acids and glycosyl-, quaternary ammonium- or alcohol-based hydrogen bond acceptors were designed and modified on the palygoskite (Pal) surface to improve the selectivity of QC via dispersive solid-phase extraction (D-SPE). The selectivity study followed the following order: Pal- [Choline chloride (ChCl)] [Levulinic acid (Lev)] > Pal- [Glycerol (Gly)] [L-Proline (Pro)] > Pal- [Glucose (Glu)] [D-lactic acid (Lac)] > Pal- [Benzyl triethyl ammonium chloride (BTBAC)] [D-lactic acid (Lac)]. Based on the single-factor method, Response surface methodology (RSM) by using a Box-Behnken design (BBD) was applied to assess the mutual interactions and effects between the three factors and the optimized preparation conditions. The optimal nanoparticles (Pal- [ChCl] [Lev]) showed the best adsorption capacity for QC (29.81 mg/g) in the mixture of methanol and phosphate buffered solution (PBS) and high selectivity which was 1.95 times and 2.12 times that of luteolin and rutin hydrate, respectively. Mechanism exploration indicated that Pal-DESs selectively adsorbed QC via electrostatic interaction, π-π stacking and hydrogen bonds. Furthermore, the screened DES of ([ChCl] [Lev]) could act on QC aqueous solution to improve its solubility and stability during preservation. The proposed QC separation strategy centered on the guiding role of DESs in selective adsorption. Additional alternatives for the synthesis of high-efficiency and hydrophilic functional adsorbents for flavonoids were made available by this green DESs regulation concept.
期刊介绍:
Applied Clay Science aims to be an international journal attracting high quality scientific papers on clays and clay minerals, including research papers, reviews, and technical notes. The journal covers typical subjects of Fundamental and Applied Clay Science such as:
• Synthesis and purification
• Structural, crystallographic and mineralogical properties of clays and clay minerals
• Thermal properties of clays and clay minerals
• Physico-chemical properties including i) surface and interface properties; ii) thermodynamic properties; iii) mechanical properties
• Interaction with water, with polar and apolar molecules
• Colloidal properties and rheology
• Adsorption, Intercalation, Ionic exchange
• Genesis and deposits of clay minerals
• Geology and geochemistry of clays
• Modification of clays and clay minerals properties by thermal and physical treatments
• Modification by chemical treatments with organic and inorganic molecules(organoclays, pillared clays)
• Modification by biological microorganisms. etc...