Supercritical carbon dioxide as solvent for manufacturing of ibuprofen loaded gelatine sponges with enhanced performance

IF 3.8 3区工程技术 Q3 ENERGY & FUELS Chemical Engineering and Processing - Process Intensification Pub Date : 2024-11-01 DOI:10.1016/j.cep.2024.110038

Senlin Li , Yifan Zheng , Zhihao Zhang , Shengao Xu , Yuan Pu , Dan Wang

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Abstract

Supercritical carbon dioxide was used as the solvent for manufacturing of ibuprofen loaded gelatine sponges with high loading capacity and fast release performance toward healthcare materials in the treatment of postoperative dental pain. The solubility of ibuprofen in supercritical CO₂ was first determined at 313 K under different pressure conditions. The micronisation of ibuprofen drugs were successfully adsorbed onto the surface of network pore system of gelatine sponges via supercritical CO₂ processing. The loading capacity of ibuprofen in gelatine sponges obtained by using supercritical CO₂ as the solvent can be up to 19.86 wt%, which was double that of the sample prepared by direct soaking in ethanol. The dissolution of ibuprofen was determined and higher instantaneous dissolution rate was observed for the ibuprofen loaded gelatine sponges synthesized by supercritical CO₂ processing.

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以超临界二氧化碳为溶剂生产性能更佳的布洛芬明胶海绵

利用超临界二氧化碳作为溶剂，制造出了布洛芬负载明胶海绵，这种海绵具有高负载能力和快速释放性能，可用于治疗牙科术后疼痛的保健材料。首先测定了布洛芬在不同压力条件下于 313 K 的超临界二氧化碳中的溶解度。通过超临界 CO₂处理，布洛芬药物的微粉化被成功吸附到明胶海绵的网孔系统表面。以超临界 CO₂为溶剂制备的明胶海绵的布洛芬负载能力可达 19.86 wt%，是直接浸泡在乙醇中制备的样品的两倍。对布洛芬的溶解度进行了测定，结果表明用超临界 CO₂ 处理合成的布洛芬明胶海绵的瞬时溶解度更高。

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来源期刊

Chemical Engineering and Processing - Process Intensification 工程技术-工程：化工

CiteScore

7.80

自引率

9.30%

发文量

408

审稿时长

49 days

期刊介绍： Chemical Engineering and Processing: Process Intensification is intended for practicing researchers in industry and academia, working in the field of Process Engineering and related to the subject of Process Intensification.Articles published in the Journal demonstrate how novel discoveries, developments and theories in the field of Process Engineering and in particular Process Intensification may be used for analysis and design of innovative equipment and processing methods with substantially improved sustainability, efficiency and environmental performance.