In vivo models of infection: Large animals – Mini review on human-scale one-stage revision in a porcine osteomyelitis model

IF 2.2 3区 医学 Q3 CRITICAL CARE MEDICINE Injury-International Journal of the Care of the Injured Pub Date : 2024-11-01 DOI:10.1016/j.injury.2024.111842
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Abstract

Animal models are essential for orthopedic infectious research. However, only few models are currently able to capture the complex and multidisciplinary treatment approach for osteomyelitis. To replicate treatment situations in their entirety, large animal models are needed, and the most used species are sheep and pigs. Herein, we review a well-characterized and reproducible porcine model of human-scale one-stage revision of implant-associated osteomyelitis that can be used for robust preclinical testing of operative and post-operative interventions. The pros and cons of the model are discussed in the context of existing literature on large animal revision models.
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体内感染模型:大型动物 - 在猪骨髓炎模型中进行人类规模的单阶段翻修的小型综述
动物模型对骨科感染性研究至关重要。然而,目前只有少数模型能够捕捉到骨髓炎复杂和多学科的治疗方法。要全面复制治疗情况,需要大型动物模型,而使用最多的物种是绵羊和猪。在此,我们回顾了一种特征明确、可重复的猪模型,该模型可用于种植体相关骨髓炎的人类规模单阶段翻修,可用于手术和术后干预措施的临床前稳健测试。我们结合现有的大型动物翻修模型文献,讨论了该模型的优缺点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.00
自引率
8.00%
发文量
699
审稿时长
96 days
期刊介绍: Injury was founded in 1969 and is an international journal dealing with all aspects of trauma care and accident surgery. Our primary aim is to facilitate the exchange of ideas, techniques and information among all members of the trauma team.
期刊最新文献
Editorial Board Fracture-related infection blood-based biomarkers: Diagnostic strategies The value of current diagnostic techniques in the diagnosis of fracture-related infections: Serum markers, histology, and cultures Antimicrobial resistance: Biofilms, small colony variants, and intracellular bacteria In vivo models of infection: Large animals – Mini review on human-scale one-stage revision in a porcine osteomyelitis model
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