首页 > 最新文献

Injury-International Journal of the Care of the Injured最新文献

英文 中文
Effect of mechanical stability of osteosynthesis on infection rates: Timing of temporary and definitive fixation 骨合成的机械稳定性对感染率的影响:临时固定和最终固定的时机
IF 2.2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2024-11-01 DOI: 10.1016/j.injury.2024.111845
Fracture related infection (FRI) remains one of the most challenging complications of orthopaedic trauma surgery. Several factors contribute to FRI development but, among those, particularly interesting from the orthopaedic surgeon's perspective is the contribution of mechanical stability and timing of fracture fixation. These are indeed crucial factors both in prevention and treatment of FRI and are directly influenced by the surgeon's work. While the role of stability has been studied and discussed, the pathophysiological process regulating such role and how this influences surgeon's treatment decision making is still debated. The same applies to the ideal timing of temporary or definitive fixation which varies according to the clinical scenario considered.
In the present narrative review, we described the influence of mechanical stability on both FRI pathophysiology and on the decision making of FRI treatment. In addition, we analysed the impact of the timing of fracture fixation on the risk of FRI development particularly in those clinical scenarios where it has been shown to be specifically relevant, such as fractures affecting segments with poor soft tissue envelope, open fractures, damage control orthopaedics, and the need for soft tissue coverage.
骨折相关感染(FRI)仍然是创伤骨科手术中最具挑战性的并发症之一。FRI的形成有多种因素,但从矫形外科医生的角度来看,其中尤其值得关注的是机械稳定性和骨折固定时机。这些确实是预防和治疗 FRI 的关键因素,并直接受到外科医生工作的影响。虽然人们已经对稳定性的作用进行了研究和讨论,但对调节这种作用的病理生理过程以及它如何影响外科医生的治疗决策仍存在争议。在本综述中,我们阐述了机械稳定性对 FRI 病理生理学和 FRI 治疗决策的影响。此外,我们还分析了骨折固定时机对 FRI 发生风险的影响,尤其是在已证明与 FRI 特别相关的临床情况下,如影响软组织包膜不良节段的骨折、开放性骨折、损伤控制矫形以及需要软组织覆盖等。
{"title":"Effect of mechanical stability of osteosynthesis on infection rates: Timing of temporary and definitive fixation","authors":"","doi":"10.1016/j.injury.2024.111845","DOIUrl":"10.1016/j.injury.2024.111845","url":null,"abstract":"<div><div>Fracture related infection (FRI) remains one of the most challenging complications of orthopaedic trauma surgery. Several factors contribute to FRI development but, among those, particularly interesting from the orthopaedic surgeon's perspective is the contribution of mechanical stability and timing of fracture fixation. These are indeed crucial factors both in prevention and treatment of FRI and are directly influenced by the surgeon's work. While the role of stability has been studied and discussed, the pathophysiological process regulating such role and how this influences surgeon's treatment decision making is still debated. The same applies to the ideal timing of temporary or definitive fixation which varies according to the clinical scenario considered.</div><div>In the present narrative review, we described the influence of mechanical stability on both FRI pathophysiology and on the decision making of FRI treatment. In addition, we analysed the impact of the timing of fracture fixation on the risk of FRI development particularly in those clinical scenarios where it has been shown to be specifically relevant, such as fractures affecting segments with poor soft tissue envelope, open fractures, damage control orthopaedics, and the need for soft tissue coverage.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fracture-related infection blood-based biomarkers: Diagnostic strategies 骨折相关感染血液生物标志物:诊断策略。
IF 2.2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2024-11-01 DOI: 10.1016/j.injury.2024.111823
Fracture-related infections are significant postoperative complications that carry substantial patient burden and additional healthcare costs. Despite their impact on outcome, early diagnosis of these infections remains challenging due to current available tests lacking acceptable diagnostic parameters. This review compiles existing information on blood-based biomarkers that have been evaluated as early diagnostic tools and highlights the challenges in their reliability. To begin to overcome these challenges new avenues of biomarker discovery utilizing “omics” technologies and novel analytical methods are being investigated in recent years. It appears that, despite their complexity, these newer approaches may be the future in biomarker discovery for fracture-related infection diagnosis.
骨折相关感染是严重的术后并发症,会给患者带来沉重的负担和额外的医疗费用。尽管这些感染对治疗结果有影响,但由于目前可用的检测方法缺乏可接受的诊断参数,因此早期诊断这些感染仍具有挑战性。本综述汇编了已被评估为早期诊断工具的血液生物标志物的现有信息,并强调了其可靠性方面的挑战。为了克服这些挑战,近年来正在研究利用 "omics "技术和新型分析方法发现生物标志物的新途径。尽管这些新方法很复杂,但似乎可能是发现骨折相关感染诊断生物标志物的未来方向。
{"title":"Fracture-related infection blood-based biomarkers: Diagnostic strategies","authors":"","doi":"10.1016/j.injury.2024.111823","DOIUrl":"10.1016/j.injury.2024.111823","url":null,"abstract":"<div><div>Fracture-related infections are significant postoperative complications that carry substantial patient burden and additional healthcare costs. Despite their impact on outcome, early diagnosis of these infections remains challenging due to current available tests lacking acceptable diagnostic parameters. This review compiles existing information on blood-based biomarkers that have been evaluated as early diagnostic tools and highlights the challenges in their reliability. To begin to overcome these challenges new avenues of biomarker discovery utilizing “omics” technologies and novel analytical methods are being investigated in recent years. It appears that, despite their complexity, these newer approaches may be the future in biomarker discovery for fracture-related infection diagnosis.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Fracture-related infections 社论:骨折相关感染
IF 2.2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2024-11-01 DOI: 10.1016/j.injury.2024.111959
{"title":"Editorial: Fracture-related infections","authors":"","doi":"10.1016/j.injury.2024.111959","DOIUrl":"10.1016/j.injury.2024.111959","url":null,"abstract":"","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Matter 1 - Full Title Page (regular issues)/Special Issue Title page (special issues) 封面 1 - 完整扉页(常规期刊)/特刊扉页(特刊)
IF 2.2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2024-11-01 DOI: 10.1016/S0020-1383(24)00721-6
{"title":"Front Matter 1 - Full Title Page (regular issues)/Special Issue Title page (special issues)","authors":"","doi":"10.1016/S0020-1383(24)00721-6","DOIUrl":"10.1016/S0020-1383(24)00721-6","url":null,"abstract":"","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The value of current diagnostic techniques in the diagnosis of fracture-related infections: Serum markers, histology, and cultures 当前诊断技术在诊断骨折相关感染中的价值:血清标记物、组织学和培养。
IF 2.2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2024-11-01 DOI: 10.1016/j.injury.2024.111862
Although fracture-related infection (FRI) is a serious complication following bone fractures, a comprehensive definition and diagnostic criteria have only emerged in recent years. According to this consensus definition, the diagnosis of FRI is based on preoperative and intraoperative suggestive or confirmatory criteria. Serum markers, histology, and microbiological cultures are considered to play a crucial role in the FRI diagnostic pathway. However, at the time of publication of the FRI consensus definition in 2018 and its update in 2020, limited data was available on the accuracy of these diagnostic methods. This review aims to provide an overview of recent publications and discuss whether new evidence has been obtained regarding the value of these current diagnostic techniques.
Meanwhile, several studies have confirmed the limited prognostic value of C-reactive protein, erythrocyte sedimentation ratio, and white blood cell count. Other serologic markers for preoperative diagnosis of FRI with promising diagnostic performance are d-dimer, plasma fibrinogen, platelet count to mean platelet volume ratio, and a risk prediction model that includes soft tissue injury type and fracture complexity in addition to blood markers. However, their true diagnostic value in daily clinical practice needs to be investigated in further studies. Data on histology in FRI diagnosis is still limited, but its potential as a confirmatory criterion seems to lie in its high specificity. Recent studies indicate that tissue culture exhibits moderate sensitivity and high specificity, with sensitivity improvements achieved by sampling of five specimens and long-term culture. Implant sonication also appears to enhance the sensitivity of culture and the detection rate of polymicrobial infections.
In conclusion, the true value of diagnostic techniques is difficult to assess, in part because it is measured against a gold standard that is itself imperfect and still evolving, but also because of methodological differences in sample processing or the use of different thresholds. Nevertheless, this review has identified that the value of current diagnostic techniques is high when used in combination. To draw more accurate conclusions about the value of serum markers, histology, and culture including sonication, future studies should be prospective and utilize a greater standardization in sampling and methodological protocols.
虽然骨折相关感染(FRI)是骨折后的一种严重并发症,但全面的定义和诊断标准直到近几年才出现。根据这一共识定义,FRI 的诊断基于术前和术中的提示或确诊标准。血清标记物、组织学和微生物培养被认为在 FRI 诊断过程中起着至关重要的作用。然而,在 2018 年发布 FRI 共识定义并在 2020 年进行更新时,关于这些诊断方法准确性的数据还很有限。本综述旨在概述近期发表的文章,并讨论是否已获得有关这些现有诊断技术价值的新证据。同时,一些研究证实了 C 反应蛋白、红细胞沉降比值和白细胞计数的预后价值有限。用于 FRI 术前诊断的其他血清学标志物具有良好的诊断效果,如 d-二聚体、血浆纤维蛋白原、血小板计数与平均血小板体积比值,以及除血液标志物外还包括软组织损伤类型和骨折复杂性的风险预测模型。然而,这些指标在日常临床实践中的真正诊断价值还需要进一步研究。组织学在 FRI 诊断中的数据仍然有限,但其作为确诊标准的潜力似乎在于其高度特异性。最近的研究表明,组织培养具有中等的灵敏度和较高的特异性,通过对五个标本进行取样和长期培养可提高灵敏度。种植体超声似乎也能提高培养的灵敏度和多微生物感染的检出率。总之,诊断技术的真正价值很难评估,部分原因是它是根据金标准来衡量的,而金标准本身并不完善且仍在不断发展,另外还因为样本处理方法的差异或使用不同的阈值。尽管如此,本综述发现,当前诊断技术在联合使用时具有很高的价值。为了对血清标记物、组织学和培养(包括超声)的价值得出更准确的结论,未来的研究应该是前瞻性的,并在取样和方法规程上采用更高的标准化。
{"title":"The value of current diagnostic techniques in the diagnosis of fracture-related infections: Serum markers, histology, and cultures","authors":"","doi":"10.1016/j.injury.2024.111862","DOIUrl":"10.1016/j.injury.2024.111862","url":null,"abstract":"<div><div>Although fracture-related infection (FRI) is a serious complication following bone fractures, a comprehensive definition and diagnostic criteria have only emerged in recent years. According to this consensus definition, the diagnosis of FRI is based on preoperative and intraoperative suggestive or confirmatory criteria. Serum markers, histology, and microbiological cultures are considered to play a crucial role in the FRI diagnostic pathway. However, at the time of publication of the FRI consensus definition in 2018 and its update in 2020, limited data was available on the accuracy of these diagnostic methods. This review aims to provide an overview of recent publications and discuss whether new evidence has been obtained regarding the value of these current diagnostic techniques.</div><div>Meanwhile, several studies have confirmed the limited prognostic value of C-reactive protein, erythrocyte sedimentation ratio, and white blood cell count. Other serologic markers for preoperative diagnosis of FRI with promising diagnostic performance are d-dimer, plasma fibrinogen, platelet count to mean platelet volume ratio, and a risk prediction model that includes soft tissue injury type and fracture complexity in addition to blood markers. However, their true diagnostic value in daily clinical practice needs to be investigated in further studies. Data on histology in FRI diagnosis is still limited, but its potential as a confirmatory criterion seems to lie in its high specificity. Recent studies indicate that tissue culture exhibits moderate sensitivity and high specificity, with sensitivity improvements achieved by sampling of five specimens and long-term culture. Implant sonication also appears to enhance the sensitivity of culture and the detection rate of polymicrobial infections.</div><div>In conclusion, the true value of diagnostic techniques is difficult to assess, in part because it is measured against a gold standard that is itself imperfect and still evolving, but also because of methodological differences in sample processing or the use of different thresholds. Nevertheless, this review has identified that the value of current diagnostic techniques is high when used in combination. To draw more accurate conclusions about the value of serum markers, histology, and culture including sonication, future studies should be prospective and utilize a greater standardization in sampling and methodological protocols.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo models of infection: Large animals – Mini review on human-scale one-stage revision in a porcine osteomyelitis model 体内感染模型:大型动物 - 在猪骨髓炎模型中进行人类规模的单阶段翻修的小型综述
IF 2.2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2024-11-01 DOI: 10.1016/j.injury.2024.111842
Animal models are essential for orthopedic infectious research. However, only few models are currently able to capture the complex and multidisciplinary treatment approach for osteomyelitis. To replicate treatment situations in their entirety, large animal models are needed, and the most used species are sheep and pigs. Herein, we review a well-characterized and reproducible porcine model of human-scale one-stage revision of implant-associated osteomyelitis that can be used for robust preclinical testing of operative and post-operative interventions. The pros and cons of the model are discussed in the context of existing literature on large animal revision models.
动物模型对骨科感染性研究至关重要。然而,目前只有少数模型能够捕捉到骨髓炎复杂和多学科的治疗方法。要全面复制治疗情况,需要大型动物模型,而使用最多的物种是绵羊和猪。在此,我们回顾了一种特征明确、可重复的猪模型,该模型可用于种植体相关骨髓炎的人类规模单阶段翻修,可用于手术和术后干预措施的临床前稳健测试。我们结合现有的大型动物翻修模型文献,讨论了该模型的优缺点。
{"title":"In vivo models of infection: Large animals – Mini review on human-scale one-stage revision in a porcine osteomyelitis model","authors":"","doi":"10.1016/j.injury.2024.111842","DOIUrl":"10.1016/j.injury.2024.111842","url":null,"abstract":"<div><div>Animal models are essential for orthopedic infectious research. However, only few models are currently able to capture the complex and multidisciplinary treatment approach for osteomyelitis. To replicate treatment situations in their entirety, large animal models are needed, and the most used species are sheep and pigs. Herein, we review a well-characterized and reproducible porcine model of human-scale one-stage revision of implant-associated osteomyelitis that can be used for robust preclinical testing of operative and post-operative interventions. The pros and cons of the model are discussed in the context of existing literature on large animal revision models.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The DAIR-procedure in fracture-related infection–When and how 骨折相关感染的 DAIR 程序--何时以及如何进行
IF 2.2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2024-11-01 DOI: 10.1016/j.injury.2024.111977
This narrative review discusses treatment strategies and key considerations guiding decisions in the surgical management of fracture-related infections (FRI). Treatment options primarily revolve around two approaches: debridement antibiotics and implant retention (DAIR), or implant exchange, either in a one or multiple-stage strategy. Several considerations, including time since infection onset, implant type, stability, causative pathogens, host physiology, and soft tissue conditions, inform the choice of surgical intervention for FRI. Current literature supports the preference for a DAIR approach in cases with a short duration of ongoing symptoms, a stable implant with satisfactory fracture reduction, and a viable soft tissue envelope. Conversely, one- or multiple-stage implant exchange is deemed beneficial in instances of compromised local and systemic host physiology, mature biofilm, difficult-to-treat pathogens, intramedullary implants, and cases involving reinfections or failed DAIR procedures. Notably, these recommendations draw parallels from periprosthetic joint infection treatment strategies, constrained by the limited availability of randomized controlled trials comparing these options specifically in acute FRI. In conclusion, future perspectives call for extensive investigations into biofilm maturation and the impact of time on treatment outcomes. Additionally, there is a need for a standardized classification system for FRI to enhance the comparability of treatment outcomes in FRI management.
这篇叙述性综述讨论了骨折相关感染(FRI)手术治疗的治疗策略和主要考虑因素。治疗方案主要围绕两种方法:清创抗生素和植入物保留(DAIR)或植入物交换,可采用一个或多个阶段的策略。在选择 FRI 的手术治疗方法时要考虑多个因素,包括感染发生后的时间、种植体类型、稳定性、致病病原体、宿主生理学和软组织条件。目前的文献支持在症状持续时间短、植入物稳定、骨折复位满意、软组织包膜可行的病例中首选 DAIR 方法。相反,在局部和全身宿主生理学受损、生物膜成熟、病原体难以治疗、髓内植入物以及涉及再感染或 DAIR 手术失败的病例中,单阶段或多阶段植入物交换被认为是有益的。值得注意的是,这些建议借鉴了假体周围关节感染治疗策略,但受限于专门针对急性 FRI 的随机对照试验比较方案有限。总之,从未来的角度来看,需要对生物膜的成熟和时间对治疗效果的影响进行广泛研究。此外,还需要为 FRI 建立标准化的分类系统,以提高 FRI 治疗结果的可比性。
{"title":"The DAIR-procedure in fracture-related infection–When and how","authors":"","doi":"10.1016/j.injury.2024.111977","DOIUrl":"10.1016/j.injury.2024.111977","url":null,"abstract":"<div><div>This narrative review discusses treatment strategies and key considerations guiding decisions in the surgical management of fracture-related infections (FRI). Treatment options primarily revolve around two approaches: debridement antibiotics and implant retention (DAIR), or implant exchange, either in a one or multiple-stage strategy. Several considerations, including time since infection onset, implant type, stability, causative pathogens, host physiology, and soft tissue conditions, inform the choice of surgical intervention for FRI. Current literature supports the preference for a DAIR approach in cases with a short duration of ongoing symptoms, a stable implant with satisfactory fracture reduction, and a viable soft tissue envelope. Conversely, one- or multiple-stage implant exchange is deemed beneficial in instances of compromised local and systemic host physiology, mature biofilm, difficult-to-treat pathogens, intramedullary implants, and cases involving reinfections or failed DAIR procedures. Notably, these recommendations draw parallels from periprosthetic joint infection treatment strategies, constrained by the limited availability of randomized controlled trials comparing these options specifically in acute FRI. In conclusion, future perspectives call for extensive investigations into biofilm maturation and the impact of time on treatment outcomes. Additionally, there is a need for a standardized classification system for FRI to enhance the comparability of treatment outcomes in FRI management.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing diagnostic accuracy: 18F-FDG PET-CT scans in low-grade infection detection among post-traumatic long bone non-unions; a literature review and clinical data 评估诊断准确性:18F-FDG PET-CT 扫描在创伤后长骨非畸形中低度感染检测中的应用;文献综述和临床数据
IF 2.2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2024-11-01 DOI: 10.1016/j.injury.2024.111712

Introduction

The diagnosis of low-grade infection in post-traumatic long bone non-unions poses challenges due to the absence of clinical signs. This study aimed to review the available literature on the diagnostic accuracy of imaging techniques for low-grade infections and assess the diagnostic accuracy of 18F-FDG PET-CT scans for low-grade infection in post-traumatic long bone non-unions.

Methods

A mini-review was conducted using Pubmed in March 2024. A retrospective study was conducted including adult patients with a long bone non-union, suspected of infection. All patients underwent 18F-FDG PET-CT scans as the index test before surgical intervention, with peri‑operative cultures obtained during surgery serving as the reference standard. Quantitative analyses were performed on the standardized uptake value (SUV) measurements obtained from the 18F-FDG PET-CT scans. Diagnostic accuracy measures including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. Receiver operating characteristic (ROC) curve analysis was employed to evaluate the discriminatory ability of SUV measurements.

Results

Literature suggests that 18F-FDG PET-CT is the most accurate imaging technique to detect low-grade infections. The study included a total of 51 18F-FDG PET-CT scans and cultures from 50 patients with long bone non-unions. The diagnostic accuracy was found to be 0.67 (95 % CI 0.44–0.87). The PPV and NPV were calculated as 0.79 (95 % CI 0.53–1.00) and 0.52 (95 % CI 0.30–0.73), respectively. Quantitative analyses of SUV measurements demonstrated a low level of accuracy, with all area under the curve (AUC) values < 0.75 and ROC curves showing a trajectory fairly parallel to the diagonal line.

Conclusion and discussion

The findings of this study indicate that in post-traumatic long bone non-unions, where a low-grade fracture-related infection (FRI) is suspected, the 18F-FDG PET-CT has a performance that is advantageous over other imaging techniques. A careful interpretation of the scan results is warranted, possibly including the quantitative analysis on tracer uptake as an adjunct. Nevertheless, the diagnostic accuracy in this condition is not as good as in early-onset FRI cases, and this should be taken into account when treating these challenging cases.
导言由于没有临床症状,创伤后长骨非骨髁低位感染的诊断面临挑战。本研究旨在回顾有关低位感染影像学技术诊断准确性的现有文献,并评估 18F-FDG PET-CT 扫描对创伤后长骨非骨关节低位感染的诊断准确性。该研究是一项回顾性研究,包括疑似感染的长骨不连体成年患者。所有患者在手术治疗前均接受了 18F-FDG PET-CT 扫描作为指标检测,手术期间获得的围手术期培养物作为参考标准。通过 18F-FDG PET-CT 扫描获得的标准化摄取值 (SUV) 测量值进行定量分析。计算了诊断准确性指标,包括敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV)。结果文献表明,18F-FDG PET-CT 是检测低级别感染最准确的成像技术。该研究共纳入了 51 例 18F-FDG PET-CT 扫描和 50 例长骨非关节炎患者的培养物。诊断准确率为 0.67(95 % CI 0.44-0.87)。计算得出的 PPV 和 NPV 分别为 0.79(95 % CI 0.53-1.00)和 0.52(95 % CI 0.30-0.73)。SUV测量值的定量分析显示出较低的准确性,所有曲线下面积(AUC)值均为0.75,ROC曲线显示出与对角线相当平行的轨迹。需要对扫描结果进行仔细解读,可能还需要对示踪剂摄取量进行定量分析作为辅助手段。不过,这种情况的诊断准确性不如早发性 FRI 病例,在治疗这些具有挑战性的病例时应考虑到这一点。
{"title":"Assessing diagnostic accuracy: 18F-FDG PET-CT scans in low-grade infection detection among post-traumatic long bone non-unions; a literature review and clinical data","authors":"","doi":"10.1016/j.injury.2024.111712","DOIUrl":"10.1016/j.injury.2024.111712","url":null,"abstract":"<div><h3>Introduction</h3><div>The diagnosis of low-grade infection in post-traumatic long bone non-unions poses challenges due to the absence of clinical signs. This study aimed to review the available literature on the diagnostic accuracy of imaging techniques for low-grade infections and assess the diagnostic accuracy of <sup>18</sup>F-FDG PET-CT scans for low-grade infection in post-traumatic long bone non-unions.</div></div><div><h3>Methods</h3><div>A mini-review was conducted using Pubmed in March 2024. A retrospective study was conducted including adult patients with a long bone non-union, suspected of infection. All patients underwent <sup>18</sup>F-FDG PET-CT scans as the index test before surgical intervention, with peri‑operative cultures obtained during surgery serving as the reference standard. Quantitative analyses were performed on the standardized uptake value (SUV) measurements obtained from the <sup>18</sup>F-FDG PET-CT scans. Diagnostic accuracy measures including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. Receiver operating characteristic (ROC) curve analysis was employed to evaluate the discriminatory ability of SUV measurements.</div></div><div><h3>Results</h3><div>Literature suggests that <sup>18</sup>F-FDG PET-CT is the most accurate imaging technique to detect low-grade infections. The study included a total of 51 <sup>18</sup>F-FDG PET-CT scans and cultures from 50 patients with long bone non-unions. The diagnostic accuracy was found to be 0.67 (95 % CI 0.44–0.87). The PPV and NPV were calculated as 0.79 (95 % CI 0.53–1.00) and 0.52 (95 % CI 0.30–0.73), respectively. Quantitative analyses of SUV measurements demonstrated a low level of accuracy, with all area under the curve (AUC) values &lt; 0.75 and ROC curves showing a trajectory fairly parallel to the diagonal line.</div></div><div><h3>Conclusion and discussion</h3><div>The findings of this study indicate that in post-traumatic long bone non-unions, where a low-grade fracture-related infection (FRI) is suspected, the <sup>18</sup>F-FDG PET-CT has a performance that is advantageous over other imaging techniques. A careful interpretation of the scan results is warranted, possibly including the quantitative analysis on tracer uptake as an adjunct. Nevertheless, the diagnostic accuracy in this condition is not as good as in early-onset FRI cases, and this should be taken into account when treating these challenging cases.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone infection evolution 骨感染演变
IF 2.2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2024-11-01 DOI: 10.1016/j.injury.2024.111826
The present minireview aims to provide a context for imagination of the timespan for bone infection evolution from the origin of cellular bone tissue to modern orthopedic surgery. From a phylogenetic osteomyelitis-bracketing perspective, and due to the time of osteocyte origin, bacteria might have been able to infect the skeleton for approximately 400 million years. Thereby, bone infections happened simultaneously with central expansions of the immune system and development of terrestrial bone structure. This co-evolution might aid in explaining the many immune evasion strategies seen in the field of bone infections. Bone infection patients with long disease-free periods followed by sudden recurrence and anamnesis of long-term and low-grade infections indicate that bacteria can perform silent parasitism within bone tissue (parasitism; one organism lives on another organism, the host, causing it harm and is structurally adapted to it). The silence seems to be disturbed by immunosuppression and the present minireview shows that a compromised immune system has been associated with bone infection development across all species in the phylogenetic tree. Orthopedic surgery, including arthroplasty and osteosynthesis, favor introduction of bacteria and prosthesis/implant related infections are thus anthropogenic infections (anthropogenic; resulting from the influence of human beings on nature). In that light it is important to remember that the skeleton and immune system have not evolved for millions of years to protect titanium alloys and other metals, commonly used for orthopedic devices from bacterial invasion. Therefore, these relatively new orthopedic infection types must be seen as distinct with unique implant/prosthesis related pathophysiology and immunology.
本小节旨在提供一个背景,以想象从细胞骨组织起源到现代骨科手术的骨感染进化时间跨度。从骨髓炎系统发育的角度来看,由于骨细胞起源的时间,细菌感染骨骼的时间可能已经长达约 4 亿年。因此,骨骼感染是与免疫系统的中心扩张和陆地骨骼结构的发展同时发生的。这种共同进化可能有助于解释骨感染领域出现的多种免疫逃避策略。骨感染患者在长期无病后突然复发,并有长期和低度感染的病史,这表明细菌可以在骨组织内进行无声寄生(寄生:一种生物寄生在另一种生物(宿主)身上,对宿主造成伤害,并在结构上与宿主相适应)。这种无声寄生似乎会受到免疫抑制的干扰,本综述显示,在系统发育树的所有物种中,免疫系统受损与骨感染的发生都有关联。骨科手术(包括关节成形术和骨合成术)有利于引入细菌,因此与假体/植入物相关的感染属于人为感染(人为;人类对自然的影响所致)。有鉴于此,重要的是要记住,骨骼和免疫系统在数百万年的进化过程中并没有保护矫形装置常用的钛合金和其他金属免受细菌入侵。因此,必须将这些相对较新的骨科感染类型视为与植入物/假体相关的独特病理生理学和免疫学。
{"title":"Bone infection evolution","authors":"","doi":"10.1016/j.injury.2024.111826","DOIUrl":"10.1016/j.injury.2024.111826","url":null,"abstract":"<div><div>The present minireview aims to provide a context for imagination of the timespan for bone infection evolution from the origin of cellular bone tissue to modern orthopedic surgery. From a phylogenetic osteomyelitis-bracketing perspective, and due to the time of osteocyte origin, bacteria might have been able to infect the skeleton for approximately 400 million years. Thereby, bone infections happened simultaneously with central expansions of the immune system and development of terrestrial bone structure. This co-evolution might aid in explaining the many immune evasion strategies seen in the field of bone infections. Bone infection patients with long disease-free periods followed by sudden recurrence and anamnesis of long-term and low-grade infections indicate that bacteria can perform silent parasitism within bone tissue (parasitism; one organism lives on another organism, the host, causing it harm and is structurally adapted to it). The silence seems to be disturbed by immunosuppression and the present minireview shows that a compromised immune system has been associated with bone infection development across all species in the phylogenetic tree. Orthopedic surgery, including arthroplasty and osteosynthesis, favor introduction of bacteria and prosthesis/implant related infections are thus <em>anthropogenic infections</em> (anthropogenic; resulting from the influence of human beings on nature). In that light it is important to remember that the skeleton and immune system have not evolved for millions of years to protect titanium alloys and other metals, commonly used for orthopedic devices from bacterial invasion. Therefore, these relatively new orthopedic infection types must be seen as distinct with unique implant/prosthesis related pathophysiology and immunology.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timing of debridement: When to do it, and who should perform it? 清创的时机:何时进行,由谁进行?
IF 2.2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2024-11-01 DOI: 10.1016/j.injury.2024.111604
The timely and effective management of open fractures continues to be a challenge in modern orthopaedic practice. Lower limb high energy fractures with complex soft tissue injuries require multi-disciplinary care to achieve the best results. Despite an extensive published literature on open fractures, the timing of debridement and the most appropriate personnel to perform it continue to be a source of debate. National guidelines on the topic are few but they suggest immediate debridement for open fractures with highly contaminated wounds and debridement within 12 to 24 h is considered desirable for less contaminated wounds. There is actually limited evidence linking timing of debridement to infection risk but the largest studies recently published do indicate a link between delay to debridement and increasing infection risk. Most studies on management are based on a clinical model where the initial debridement and fixation are performed by an orthopaedic surgeon and if required delayed coverage and closure is subsequently carried out by a plastic surgeon. More recently, studies have proposed an alternative approach, with initial debridement and temporary fixation followed within 48 h with a further debridement, definitive fixation and flap cover with a combined orthoplastic team. Reported results have been favourable. This is a significant change in management and there are limited data at present to determine if this approach will improve results in the most complex open fractures.
及时有效地处理开放性骨折仍然是现代骨科实践中的一项挑战。下肢高能量骨折伴有复杂的软组织损伤,需要多学科护理才能达到最佳效果。尽管已出版了大量有关开放性骨折的文献,但清创的时机和最合适的清创人员仍是争论的焦点。有关该主题的国家指南很少,但它们建议对伤口污染严重的开放性骨折立即进行清创,而对污染较轻的伤口最好在 12-24 小时内进行清创。实际上,将清创时间与感染风险联系起来的证据很有限,但最近发表的最大规模的研究确实表明,清创延迟与感染风险增加之间存在联系。大多数关于伤口管理的研究都是基于一种临床模式,即由整形外科医生进行最初的清创和固定,如有需要,再由整形外科医生进行延迟覆盖和缝合。最近的研究提出了另一种方法,即由整形外科联合团队在 48 小时内进行初步清创和临时固定,然后再进行进一步清创、明确固定和皮瓣覆盖。据报道,这种方法效果良好。这是一种重大的管理变革,目前只有有限的数据可以确定这种方法是否能改善最复杂的开放性骨折的治疗效果。
{"title":"Timing of debridement: When to do it, and who should perform it?","authors":"","doi":"10.1016/j.injury.2024.111604","DOIUrl":"10.1016/j.injury.2024.111604","url":null,"abstract":"<div><div>The timely and effective management of open fractures continues to be a challenge in modern orthopaedic practice. Lower limb high energy fractures with complex soft tissue injuries require multi-disciplinary care to achieve the best results. Despite an extensive published literature on open fractures, the timing of debridement and the most appropriate personnel to perform it continue to be a source of debate. National guidelines on the topic are few but they suggest immediate debridement for open fractures with highly contaminated wounds and debridement within 12 to 24 h is considered desirable for less contaminated wounds. There is actually limited evidence linking timing of debridement to infection risk but the largest studies recently published do indicate a link between delay to debridement and increasing infection risk. Most studies on management are based on a clinical model where the initial debridement and fixation are performed by an orthopaedic surgeon and if required delayed coverage and closure is subsequently carried out by a plastic surgeon. More recently, studies have proposed an alternative approach, with initial debridement and temporary fixation followed within 48 h with a further debridement, definitive fixation and flap cover with a combined orthoplastic team. Reported results have been favourable. This is a significant change in management and there are limited data at present to determine if this approach will improve results in the most complex open fractures.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Injury-International Journal of the Care of the Injured
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1