Improvement of antibacterial activity of AgNPs@PVA-PVP ternary nanocomposite films followed by gamma-ray irradiation treatment for biomedical applications

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL Radiation Physics and Chemistry Pub Date : 2024-10-23 DOI:10.1016/j.radphyschem.2024.112345

Mohammed G.M. Zeariya , Sara Kh.M. El-Shennawy , Ahmed Kassar , Mohammed Ismail Humaida , Rakesh Kumar , Mostafa Ahmed Mohammed , M.A. El-Morsy , A.A. Menazea

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Abstract

Our study investigates the influence of several doses of gamma rays on the antibacterial behavior of nanocomposite of silver nanoparticles (AgNPs) doped in a blend of poly (vinyl alcohol) (PVA)-Polyvinyl Pyrrolidone (PVP). AgNPs@PVA-PVP nanocomposite films were fabricated via laser ablation route, and then the synthesized films were subjected to various gamma ray's doses. X-ray diffraction (XRD) data shows a diffraction peak at 2θ = 38° assigned to the existence of AgNPs. Ultraviolet–visible (UV–Vis) results confirm the characteristic peak of silver nanoparticles at 425 nm. The cell viability and antibacterial behavior results confirmed the enhancement in the performance of AgNPs@PVA-PVP composite after irradiated to gamma rays. These values of cell viability have been raised by increasing the dose of gamma rays to 94.5 ± 6.5 % for dose at 70 kGy gamma rays. The values of the inhibition zone of microorganisms were enhanced by raising the doses of gamma rays to 19.5 ± 0.5 and 21.3 ± 0.6 against E. coli and S. aureus respectively specifically for nanocomposite with gamma dose 70 kGy. Thus, the improved antibacterial activity of AgNPs@PVA-PVP nanocomposite could be used in biomedical applications.

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通过伽马射线辐照处理提高 AgNPs@PVA-PVP 三元纳米复合膜的抗菌活性，用于生物医学应用

我们的研究探讨了不同剂量的伽马射线对掺杂在聚乙烯醇（PVA）-聚乙烯吡咯烷酮（PVP）共混物中的银纳米粒子（AgNPs）纳米复合材料抗菌行为的影响。AgNPs@PVA-PVP纳米复合薄膜是通过激光烧蚀的方法制备的，然后对合成的薄膜进行不同剂量的伽马射线照射。X 射线衍射（XRD）数据显示，在 2θ = 38° 处有一个衍射峰，表明存在 AgNPs。紫外可见（UV-Vis）结果证实了银纳米粒子在 425 纳米波长处的特征峰。细胞存活率和抗菌行为结果证实，AgNPs@PVA-PVP 复合材料经伽马射线照射后性能增强。当伽马射线剂量为 70 kGy 时，细胞存活率提高到 94.5 ± 6.5 %。伽马射线剂量为 70 kGy 时，纳米复合材料对大肠杆菌和金黄色葡萄球菌的抑制区分别为 19.5 ± 0.5 和 21.3 ± 0.6。因此，AgNPs@PVA-PVP 纳米复合材料抗菌活性的提高可用于生物医学领域。

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.