{"title":"Otostegia fruticosa (Forssk.) – A comprehensive insight of its ethnopharmacology, phytochemistry, and pharmacological activities","authors":"","doi":"10.1016/j.jsps.2024.102189","DOIUrl":null,"url":null,"abstract":"<div><div>Otostegia fruticosa<!--> <!-->(Forssk.) is a shrub of the Lamiaceae family with a wide geographic distribution in Saudi Arabia, Western and Eastern Africa, Ethiopia, and the Middle East. The current study provides an overview of recent developments in the knowledge of<!--> <em>O. fruticosa</em>’s<!--> <!-->ethnobotanical, pharmacological, and phytochemical properties. In folkloric medicine, it has been used since ancient times for gastrointestinal disorders, oral health, ocular irritation, antiparasitic, diarrhea, tonsillitis, arthritis, respiratory complications, and sunstroke treatment. Pharmacological investigations of its antibacterial, antioxidant, anti-inflammatory, cytotoxic, analgesic, larvicidal, nephroprotective, and other effects further validated its folklore practice. A range of diterpenoids, triterpenes, flavonoids, and essential oils have been found in<!--> <em>O. fruticosa</em>, according to phytochemical studies, which are thought to be responsible for the pharmacological effects of this plant species. This scientific review summarizes the most important secondary metabolites isolated from the <em>O</em>. <em>fruticosa</em>. It also summarizes the biological activities, providing insights into further scientific exploration.</div></div>","PeriodicalId":49257,"journal":{"name":"Saudi Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Saudi Pharmaceutical Journal","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1319016424002408","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Otostegia fruticosa (Forssk.) is a shrub of the Lamiaceae family with a wide geographic distribution in Saudi Arabia, Western and Eastern Africa, Ethiopia, and the Middle East. The current study provides an overview of recent developments in the knowledge of O. fruticosa’s ethnobotanical, pharmacological, and phytochemical properties. In folkloric medicine, it has been used since ancient times for gastrointestinal disorders, oral health, ocular irritation, antiparasitic, diarrhea, tonsillitis, arthritis, respiratory complications, and sunstroke treatment. Pharmacological investigations of its antibacterial, antioxidant, anti-inflammatory, cytotoxic, analgesic, larvicidal, nephroprotective, and other effects further validated its folklore practice. A range of diterpenoids, triterpenes, flavonoids, and essential oils have been found in O. fruticosa, according to phytochemical studies, which are thought to be responsible for the pharmacological effects of this plant species. This scientific review summarizes the most important secondary metabolites isolated from the O. fruticosa. It also summarizes the biological activities, providing insights into further scientific exploration.
Otostegia fruticosa(Forssk.)是一种唇形科灌木,广泛分布于沙特阿拉伯、非洲西部和东部、埃塞俄比亚和中东地区。目前的研究概述了有关 O. fruticosa 的民族植物学、药理学和植物化学特性的最新进展。在民间医药中,它自古以来就被用于治疗胃肠道疾病、口腔健康、眼部刺激、抗寄生虫、腹泻、扁桃体炎、关节炎、呼吸系统并发症和中暑。对其抗菌、抗氧化、抗炎、细胞毒性、镇痛、杀幼虫、保护肾脏等功效的药理研究进一步验证了其民间做法。根据植物化学研究发现,O. fruticosa 中含有一系列二萜类、三萜类、黄酮类和精油,这些物质被认为是该植物物种药理作用的主要成分。这篇科学综述总结了从 O. fruticosa 分离出来的最重要的次生代谢物。它还总结了其生物活性,为进一步的科学探索提供了启示。
期刊介绍:
The Saudi Pharmaceutical Journal (SPJ) is the official journal of the Saudi Pharmaceutical Society (SPS) publishing high quality clinically oriented submissions which encompass the various disciplines of pharmaceutical sciences and related subjects. SPJ publishes 8 issues per year by the Saudi Pharmaceutical Society, with the cooperation of the College of Pharmacy, King Saud University.