Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo

IF 20.6 Q1 OPTICS Light-Science & Applications Pub Date : 2024-10-31 DOI:10.1038/s41377-024-01644-6
Jing Lv, Hengrong Lan, Aoji Qin, Tong Sun, Dan Shao, Fei Gao, Junjie Yao, Kamran Avanaki, Liming Nie
{"title":"Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo","authors":"Jing Lv, Hengrong Lan, Aoji Qin, Tong Sun, Dan Shao, Fei Gao, Junjie Yao, Kamran Avanaki, Liming Nie","doi":"10.1038/s41377-024-01644-6","DOIUrl":null,"url":null,"abstract":"<p>Advancements in precision medicine necessitate understanding drug clearance pathways, especially in organs like the liver and kidneys. Traditional techniques such as PET/CT pose radiation hazards, whereas optical imaging poses challenges in maintaining both depth penetration and high resolution. Moreover, very few longitudinal studies have been performed for drug candidates for different symptoms. Leveraging non-ionizing photoacoustic tomography for deep tissue imaging, we developed a spatiotemporally resolved clearance pathway tracking (SRCPT) method, providing unprecedented insights into drug clearance dynamics within vital organs. SRCPT addresses challenges like laser fluence attenuation, enabling dynamic visualization of drug clearance pathways and essential parameter extraction. We employed a novel frequency component selection based synthetic aperture focusing technique (FCS-SAFT) with respiratory-artifacts-free weighting factors to enhance three-dimensional imaging resolutions. Inspired by this, we investigated the clearance pathway of a clinical drug, mitoxantrone, revealing reduced liver clearance when hepatic function is impaired. Furthermore, immunoglobulin G clearance analysis revealed significant differences among mice with varying renal injury degrees. The accuracy of our method was validated using a double-labeled probe [<sup>68</sup>Ga]DFO-IRDye800CW, showing a strong positive correlation between SRCPT and PET. We believe that this powerful SRCPT promises precise mapping of drug clearance pathways and enhances diagnosis and treatment of liver and kidney-related diseases.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":null,"pages":null},"PeriodicalIF":20.6000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Light-Science & Applications","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.1038/s41377-024-01644-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPTICS","Score":null,"Total":0}
引用次数: 0

Abstract

Advancements in precision medicine necessitate understanding drug clearance pathways, especially in organs like the liver and kidneys. Traditional techniques such as PET/CT pose radiation hazards, whereas optical imaging poses challenges in maintaining both depth penetration and high resolution. Moreover, very few longitudinal studies have been performed for drug candidates for different symptoms. Leveraging non-ionizing photoacoustic tomography for deep tissue imaging, we developed a spatiotemporally resolved clearance pathway tracking (SRCPT) method, providing unprecedented insights into drug clearance dynamics within vital organs. SRCPT addresses challenges like laser fluence attenuation, enabling dynamic visualization of drug clearance pathways and essential parameter extraction. We employed a novel frequency component selection based synthetic aperture focusing technique (FCS-SAFT) with respiratory-artifacts-free weighting factors to enhance three-dimensional imaging resolutions. Inspired by this, we investigated the clearance pathway of a clinical drug, mitoxantrone, revealing reduced liver clearance when hepatic function is impaired. Furthermore, immunoglobulin G clearance analysis revealed significant differences among mice with varying renal injury degrees. The accuracy of our method was validated using a double-labeled probe [68Ga]DFO-IRDye800CW, showing a strong positive correlation between SRCPT and PET. We believe that this powerful SRCPT promises precise mapping of drug clearance pathways and enhances diagnosis and treatment of liver and kidney-related diseases.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
动态合成扫描光声跟踪监测体内外源探针的肝脏和肾脏清除途径
精准医疗的发展要求了解药物清除途径,尤其是肝脏和肾脏等器官的清除途径。正电子发射计算机断层显像(PET/CT)等传统技术存在辐射危害,而光学成像在保持深度穿透和高分辨率方面也面临挑战。此外,针对不同症状的候选药物很少进行纵向研究。利用用于深部组织成像的非电离光声断层成像技术,我们开发了一种时空分辨清除路径跟踪(SRCPT)方法,为重要器官内的药物清除动态提供了前所未有的洞察力。SRCPT 解决了激光通量衰减等难题,实现了药物清除路径的动态可视化和基本参数提取。我们采用了一种新颖的基于频率成分选择的合成孔径聚焦技术(FCS-SAFT)和无呼吸伪影加权因子,以提高三维成像分辨率。受此启发,我们研究了临床药物米托蒽醌的清除途径,发现当肝功能受损时,肝脏的清除率会降低。此外,免疫球蛋白 G 清除率分析表明,不同肾损伤程度的小鼠之间存在显著差异。我们使用双标记探针[68Ga]DFO-IRDye800CW验证了我们方法的准确性,结果显示 SRCPT 和 PET 之间存在很强的正相关性。我们相信,这种功能强大的 SRCPT 可精确绘制药物清除途径图,提高肝肾相关疾病的诊断和治疗水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Light-Science & Applications
Light-Science & Applications 数理科学, 物理学I, 光学, 凝聚态物性 II :电子结构、电学、磁学和光学性质, 无机非金属材料, 无机非金属类光电信息与功能材料, 工程与材料, 信息科学, 光学和光电子学, 光学和光电子材料, 非线性光学与量子光学
自引率
0.00%
发文量
803
审稿时长
2.1 months
期刊最新文献
Quantum sensing with optically accessible spin defects in van der Waals layered materials Polaritons light up future displays Color-conversion displays: current status and future outlook Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo Shape optimization for high efficiency metasurfaces: theory and implementation
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1