Exploring the Association Between Cognitive Decline and Triglyceride-Glucose Index: A Systematic Review and Meta-Analysis

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES Brain and Behavior Pub Date : 2024-10-31 DOI:10.1002/brb3.70131

Elina Ghondaghsaz, Amirmohammad Khalaji, Mehrdad Mahalleh, Mahdi Masrour, Parsa Mohammadi, Alessandro Cannavo, Amir Hossein Behnoush

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Abstract

Background

Cognitive decline and dementia are debilitating conditions that compromise the quality of life and charge the healthcare system with a substantial socioeconomic burden. In this context, emerging evidence supports an association between the triglyceride-glucose index (TyG), a surrogate insulin resistance marker, and cognitive decline and dementia. Hence, we systematically reviewed the studies assessing the TyG index in patients with cognitive decline and their controls.

Methods

Online international databases (PubMed, Scopus, Embase, and the Web of Science) were searched comprehensively for studies showing the TyG index in patients with cognitive decline/impairment. Random-effect meta-analyses were conducted to calculate the standardized mean difference (SMD), pooled odds ratio (OR), and pooled area under the curve (AUC), in addition to 95% confidence intervals (CIs) for the comparisons of groups.

Results

Seventeen studies were included in our analysis. Then, we conducted a meta-analysis, demonstrating that patients with cognitive decline had significantly higher levels of TyG index than those without (SMD 0.83, 95% CI 0.16 to 1.50, p = 0.015). Moreover, our data showed that a 1-unit increase in the TyG index was associated with higher odds of cognitive decline (adjusted OR [aOR] 2.86, 95% CI 1.49 to 5.50, p = 0.002). Further, we observed that patients in the fourth TyG quartile with higher values of the TyG index than the first quartile presented with more increased cognitive decline (aOR 1.62, 95%CI 1.11 to 2.38, p = 0.013). Finally, pooled AUC data for the diagnostic performance of the TyG index resulted in an overall AUC value of 0.73 (95% CI 0.66 to 0.79). Sensitivity and specificity were also calculated as 0.695 and 0.687, respectively.

Conclusion

This study supports the clinical utility of the TyG index in patients with cognitive decline and solicits more focused studies to consolidate its usage in clinical settings and real-world practice.

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探索认知能力下降与甘油三酯-葡萄糖指数之间的关联：系统回顾与元分析》。

背景：认知功能衰退和痴呆症是一种使人衰弱的疾病，会损害人们的生活质量，并给医疗保健系统带来巨大的社会经济负担。在这种情况下，新出现的证据支持甘油三酯-葡萄糖指数（TyG）这一替代性胰岛素抵抗标志物与认知功能衰退和痴呆症之间存在关联。因此，我们系统地回顾了评估认知能力下降患者及其对照组的 TyG 指数的研究：全面检索了在线国际数据库（PubMed、Scopus、Embase 和 Web of Science）中显示认知功能下降/受损患者TyG指数的研究。进行随机效应荟萃分析，计算标准化平均差（SMD）、集合比值比（OR）和集合曲线下面积（AUC），以及组间比较的95%置信区间（CI）：17项研究被纳入我们的分析。然后，我们进行了一项荟萃分析，结果表明认知功能下降患者的 TyG 指数水平明显高于无认知功能下降患者（SMD 0.83，95% CI 0.16 至 1.50，P = 0.015）。此外，我们的数据显示，TyG 指数每增加 1 个单位，认知功能下降的几率就会增加（调整 OR [aOR] 2.86，95% CI 1.49 至 5.50，p = 0.002）。此外，我们还观察到，TyG 指数值高于第一四分位数的第四四分位数患者认知能力下降的几率更高（aOR 1.62，95%CI 1.11 至 2.38，p = 0.013）。最后，对 TyG 指数诊断性能的 AUC 数据进行汇总，得出总的 AUC 值为 0.73（95% CI 0.66 至 0.79）。灵敏度和特异度的计算结果也分别为 0.695 和 0.687：本研究支持TyG指数在认知功能减退患者中的临床实用性，并要求进行更多有针对性的研究，以巩固其在临床环境和实际实践中的应用。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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