The Dectin-1 and Dectin-2 clusters: C-type lectin receptors with fundamental roles in immunity.

IF 6.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY EMBO Reports Pub Date : 2024-10-31 DOI:10.1038/s44319-024-00296-2

Mariano Malamud, Gordon D Brown

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Abstract

The ability of myeloid cells to recognize and differentiate endogenous or exogenous ligands rely on the presence of different transmembrane protein receptors. C-type lectin receptors (CLRs), defined by the presence of a conserved structural motif called C-type lectin-like domain (CTLD), are a crucial family of receptors involved in this process, being able to recognize a diverse range of ligands from glycans to proteins or lipids and capable of initiating an immune response. The Dectin-1 and Dectin-2 clusters involve two groups of CLRs, with genes genomically linked within the natural killer cluster of genes in both humans and mice, and all characterized by the presence of a single extracellular CTLD. Fundamental immune cell functions such as antimicrobial effector mechanisms as well as internalization and presentation of antigens are induced and/or regulated through activatory, or inhibitory signalling pathways triggered by these receptors after ligand binding. In this review, we will discuss the most recent concepts regarding expression, ligands, signaling pathways and functions of each member of the Dectin clusters of CLRs, highlighting the importance and diversity of their functions.

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Dectin-1 和 Dectin-2 簇：在免疫中发挥重要作用的 C 型凝集素受体。

髓系细胞识别和分化内源性或外源性配体的能力依赖于不同跨膜蛋白受体的存在。C型凝集素受体（CLRs）由一个名为C型凝集素样结构域（CTLD）的保守结构基团定义，是参与这一过程的重要受体家族，能够识别从糖类到蛋白质或脂类的各种配体，并能启动免疫反应。Dectin-1和Dectin-2簇涉及两组CLR，其基因在人类和小鼠的自然杀伤基因簇中都有基因组联系，其特点都是存在单一的细胞外CTLD。免疫细胞的基本功能，如抗菌效应机制以及抗原的内化和呈递，都是在配体结合后通过这些受体触发的激活或抑制信号通路诱导和/或调节的。在这篇综述中，我们将讨论有关 CLRs Dectin 簇中每个成员的表达、配体、信号传导途径和功能的最新概念，强调其功能的重要性和多样性。

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来源期刊

EMBO Reports 生物-生化与分子生物学

CiteScore

11.20

自引率

1.30%

发文量

267

审稿时长

1 months

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