Effective management of multidrug-resistant HIV with lenacapavir and fostemsavir: A case study.

IF 1.4 4区 医学 Q4 IMMUNOLOGY International Journal of STD & AIDS Pub Date : 2024-11-01 DOI:10.1177/09564624241296583
Francisca Bartilotti Matos, Dara Mbanze, Perpétua Gomes, Cristóvão Figueiredo, Daniel Coutinho, Sofia Nunes, Carlos Azevedo, Joana Fragoso, Tiago Teixeira, Luís Malheiro
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Abstract

Resistance to antiretroviral therapy is an increasing challenge in the management of HIV. We present the case of a woman living with HIV, with a history of multiple treatment regimens and resistances to antiretrovirals, who has been successfully treated with a combination of lenacapavir and fostemsavir for the past year, obtaining an undetectable viral load within one month of starting therapy and reporting no serious side effects. This case is amongst the first to document the combined use of lenacapivir and fostemsavir in treating multidrug-resistant HIV. It supports the potential of these novel agents in managing complex cases of HIV resistance.

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来那卡韦和福斯替沙韦对耐多药艾滋病病毒的有效管理:案例研究。
抗逆转录病毒疗法耐药是艾滋病治疗过程中面临的一个日益严峻的挑战。我们介绍了一名女性艾滋病感染者的病例,她曾接受过多种治疗方案,对抗逆转录病毒药物产生了耐药性,在过去的一年里,她成功接受了来那卡韦和福斯替沙韦的联合治疗,在开始治疗后的一个月内检测不到病毒载量,也没有报告任何严重的副作用。该病例是首例来那卡韦和福斯替沙韦联合用于治疗耐多药艾滋病病毒的病例。它证明了这些新型药物在治疗复杂的HIV耐药病例方面的潜力。
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来源期刊
CiteScore
2.60
自引率
7.10%
发文量
144
审稿时长
3-6 weeks
期刊介绍: The International Journal of STD & AIDS provides a clinically oriented forum for investigating and treating sexually transmissible infections, HIV and AIDS. Publishing original research and practical papers, the journal contains in-depth review articles, short papers, case reports, audit reports, CPD papers and a lively correspondence column. This journal is a member of the Committee on Publication Ethics (COPE).
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