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Tofacitinib in alopecia areata and HIV: A curious intersection of immunomodulation, hair regrowth, and hypertrichosis.
IF 1.4 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1177/09564624251315781
Tanvi Vaidya, Monisha Madhumita

Tofacitinib is a Janus kinase 3 (JAK3) inhibitor effective in treating alopecia areata (AA) by promoting hair regrowth. Its mechanism may involve upregulation of vascular endothelial growth factor (VEGF) and reduction of inflammation. However, the range of effects, particularly on hair growth in specific populations, remains under-investigated. We describe a patient with HIV, well-controlled on antiretroviral therapy, who developed hirsutism after starting tofacitinib for AA. This unexpected side effect of hypertrichosis was completely resolved after discontinuing the medication and undergoing a single session of laser hair removal (LHR). This case highlights the potential for unusual hair growth patterns associated with tofacitinib treatment in patients with immune dysregulation. Monitoring and management strategies for such side effects are discussed. This case highlights the potential for unusual hair growth patterns associated with tofacitinib treatment in patients with immune dysregulation. Monitoring and management strategies for such side effects are discussed. The case emphasizes the need for careful monitoring of hair growth and other potential side effects in patients on tofacitinib, especially those with underlying immune-modulating conditions. It also suggests that LHR can be an effective treatment for medication-induced hirsutism.

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引用次数: 0
2024 British Association for Sexual Health and HIV (BASHH) UK national guideline on the management of vulval conditions. 2024年英国性健康和艾滋病毒协会(BASHH)英国外阴疾病管理国家指南。
IF 1.4 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-04-01 Epub Date: 2025-01-21 DOI: 10.1177/09564624241311629
Sarah K Edwards, Fiona Lewis, Imali Fernando, Lisa Haddon, Deepa Grover

BackgroundThe management of vulval disorders in Genitourinary Medicine (GUM) clinics requires targeted approaches due to the wide range of conditions affecting the vulva. Vulval diseases encompass various aetiologies, including dermatoses, pain syndromes, and pre-malignant conditions, necessitating specialized care often involving multidisciplinary collaboration.PurposeThis guideline aims to provide evidence-based recommendations for the diagnosis and management of specific vulval conditions that may present in GUM clinics. The focus is on conditions commonly managed by Genitourinary Physicians, either independently or in partnership with other specialists, depending on available local expertise. Additionally, guidance on onward referral is included to ensure optimal patient care.Study SampleThe guideline primarily addresses the management of individuals aged 16 years and older presenting to GUM clinics with non-infective vulval conditions.Data CollectionRecommendations within this guideline are derived from a review of existing literature, clinical expertise, and consensus among specialists. Emphasis is placed on diagnostic tests and treatment regimens tailored to the following conditions: Lichen sclerosus, Lichen planus, Eczema, Lichen simplex, Psoriasis, Vulval high-grade squamous intraepithelial lesions (previously vulval intraepithelial neoplasia), Vulval pain syndromes, and Non-sexually acquired acute genital ulceration (Ulcer of Lipschütz).ConclusionsThis guideline offers practical recommendations for the effective management of specific vulval disorders in GUM settings. It is not intended to be a comprehensive review of all vulval diseases but rather a focused resource to assist clinicians in providing high-quality, patient-centred care. Onward referral pathways are also outlined to support collaborative and multidisciplinary management of complex cases.

背景:生殖泌尿医学(GUM)诊所的外阴疾病管理需要有针对性的方法,因为影响外阴的条件范围很广。外阴疾病包括各种病因,包括皮肤病、疼痛综合征和恶性前病变,需要经常涉及多学科合作的专门护理。目的:本指南旨在为龈临床可能出现的特定外阴疾病的诊断和管理提供循证建议。重点是通常由泌尿生殖系统医生独立或与其他专家合作管理的疾病,具体取决于当地的专业知识。此外,指导转诊包括,以确保最佳的病人护理。研究样本:该指南主要针对在牙龈诊所就诊的16岁及以上非感染性外阴疾病患者的管理。数据收集:本指南中的建议来自对现有文献、临床专业知识和专家共识的回顾。重点是针对以下情况量身定制的诊断测试和治疗方案:硬化地衣、扁平地衣、湿疹、单纯性地衣、银屑病、外阴高度鳞状上皮内病变(以前的外阴上皮内瘤变)、外阴疼痛综合征和非性获得性急性生殖器溃疡(lipsch溃疡)。结论:本指南为GUM患者特殊外阴疾病的有效治疗提供了实用建议。它的目的不是全面审查所有外阴疾病,而是一个重点资源,以协助临床医生提供高质量的,以病人为中心的护理。后续转诊途径也概述,以支持复杂病例的协作和多学科管理。
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引用次数: 0
A correspondence on elevated IL-10 serum levels are associated with slower serological response following syphilis treatment during pregnancy. 妊娠期梅毒治疗后血清IL-10水平升高与血清学反应较慢相关。
IF 1.4 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-04-01 Epub Date: 2025-01-21 DOI: 10.1177/09564624251315785
Chenwei Diao, Huan Wang
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引用次数: 0
Determination of depression prevalence in pregnant women living with HIV aged 18 years and older: A meta-analysis study.
IF 1.4 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-04-01 Epub Date: 2025-01-28 DOI: 10.1177/09564624251316048
Sibel Gürbüz, Elif Nur Yildirim Öztürk, Simge Sari, Saliha Kazci, Meltem Çöl

BackgroundPregnant women living with HIV are known to be at higher risk of depression than pregnant women without HIV. Accompanied by a systematic literature review, the aim of this study was to determine the global prevalence of depression in pregnant women living with HIV.MethodsPubMed, Scopus, Google Scholar and Web of Science databases were searched. The references of the included publications and a similar meta-analysis study were also reviewed. The 19 included studies were assessed for quality using standard forms. Pooled prevalence was calculated using a random effects model. Heterogeneity and publication bias were assessed using various methods. Subgroup analyses and meta-regression were also performed.ResultsOf the 19 studies included in the review, six of the studies were published between 2008 and 2014, and 13 were published between 2017 and 2023. 15 studies were conducted in African countries. According to study type, eight studies were cross-sectional and seven were cohort studies. The pooled prevalence of depression was calculated to be 45%. The prevalence in African countries was 37.7%. The studies were found to be statistically significantly heterogeneous. Tests and funnel plots showed no publication bias in this meta-analysis. The variables place, study type and scale made the model significant in the meta-regression.ConclusionIn this meta-analysis, 6379 women aged 18 years and older were examined and their depression levels were found to be high. Taking steps to struggle with HIV and depression in people living with HIV seems important.

背景:众所周知,与未感染艾滋病毒的孕妇相比,感染艾滋病毒的孕妇患抑郁症的风险更高。本研究通过系统性文献回顾,旨在确定全球感染 HIV 的孕妇中抑郁症的发病率:方法:检索了 PubMed、Scopus、Google Scholar 和 Web of Science 数据库。方法:对 PubMopus、Scopus、Google Scholar 和 Web Science 数据库进行了检索,并查阅了所纳入出版物的参考文献和一项类似的荟萃分析研究。采用标准表格对纳入的 19 项研究进行了质量评估。使用随机效应模型计算了汇总流行率。采用多种方法对异质性和发表偏倚进行了评估。此外,还进行了分组分析和元回归分析:在纳入综述的 19 项研究中,6 项研究发表于 2008 年至 2014 年,13 项研究发表于 2017 年至 2023 年。15项研究在非洲国家进行。根据研究类型,8 项研究为横断面研究,7 项为队列研究。经计算,抑郁症的合计患病率为 45%。非洲国家的患病率为 37.7%。这些研究在统计学上存在明显的异质性。测试和漏斗图显示,该荟萃分析没有发表偏倚。地点、研究类型和规模等变量使元回归模型具有显著性:在这项荟萃分析中,共研究了 6379 名 18 岁及以上的女性,发现她们的抑郁水平较高。采取措施与艾滋病病毒感染者和抑郁症作斗争似乎很重要。
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引用次数: 0
Use of patient portals to disclose STI test histories to sex partners among U.S. men who have sex with men: A call for research and guidance. 使用患者门户网站向美国男男性行为者的性伴侣披露STI检测历史:呼吁进行研究和指导。
IF 1.4 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-04-01 Epub Date: 2025-01-21 DOI: 10.1177/09564624251315783
Kevon-Mark P Jackman, Kaitlyn Atkins, Sarah M Murray, Tom Carpino, Iaah Lucas, Travis Sanchez, Stefan Baral

BackgroundThis study investigates the use of patient portals for disclosing sexually transmitted infection (STI) test result histories to sexual partners among men who have sex with men (MSM) in the United States.MethodsUsing data from the 2022-2023 American Men's Internet Survey, this cross-sectional analysis examined demographic, behavioral, and healthcare-related factors associated with MSM's utilization of patient portals for sharing STI test results. Participants (N = 2601) were surveyed on portal use, STI testing frequency, and partner disclosure practices.Results18% of survey participants used portals to disclose a STI test result to parrtners, with higher prevalences among individuals aged 16-37 years old versus 56 years and older, black non-Hispanic (26.4%) versus white non-Hispanic (16.8%), and those reporting nine or more times being tested for STIs (30.1%) versus 1 to 3 times (7.5%). Participants reporting sex work (33.3% vs 17.7%) and HIV pre-exposure prophylaxis (PrEP) use (24.2% vs 13.0%) also had a higher prevalence of portal use for disclosure. Multivariable Poisson regression analysis with robust error variance showed that sexual behavioral stigma from family and friends [adjusted prevalence ratio (aPR) = 1.11; p = .04] also, being tested for STIs four to 8 (aPR = 2.21; p < .001) and nine or more times aPR = 3.42; p < .001) were significantly associated with prevalence of portal-based disclosure.ConclusionFindings suggest patient portals may be viable tools for STI prevention in MSM communities, especially among individuals with increased vulnerability to STI acquisition. Addressing disparities in portal access and explaining patient portal capabilities may enhance the role of digital health in reducing STI transmission among MSM communities.

背景:本研究调查了美国男男性行为者(MSM)使用患者门户网站向性伴侣披露性传播感染(STI)检测结果历史的情况。方法:利用2022-2023年美国男性互联网调查的数据,本横断面分析检查了与男男性行为者利用患者门户网站分享性病检测结果相关的人口统计学、行为和医疗相关因素。对参与者(N = 2601)进行了门户使用、STI检测频率和合作伙伴披露实践的调查。结果:18%的调查参与者使用门户网站向伴侣披露性传播感染检测结果,16-37岁人群的患病率高于56岁及以上人群,非西班牙裔黑人(26.4%)高于非西班牙裔白人(16.8%),报告接受过9次或以上性传播感染检测的人群(30.1%)高于1至3次(7.5%)。报告性工作的参与者(33.3%对17.7%)和使用艾滋病毒暴露前预防(PrEP)的参与者(24.2%对13.0%)使用门户网站进行信息披露的比例也较高。多变量泊松回归分析显示,来自家人和朋友的性行为污名化[校正患病率(aPR) = 1.11;p = .04]接受性传播感染4 ~ 8次检测(aPR = 2.21;p < 0.001), 9倍以上aPR = 3.42;P < 0.001)与基于门户的信息披露的流行率显著相关。结论:研究结果表明,患者门户网站可能是MSM社区预防性传播感染的可行工具,特别是在性传播感染易感性增加的人群中。解决门户访问方面的差异并解释患者门户的功能,可能会增强数字卫生在减少男男性行为者社区间性传播感染方面的作用。
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引用次数: 0
Pneumocystis jirovecii pneumonia co-infection with cytomegalovirus pneumonia in a patient with acquired immunodeficiency syndrome: A case report and literature review. 乙肝肺囊虫肺炎合并巨细胞病毒肺炎一例获得性免疫缺陷综合征病例报告并文献复习。
IF 1.4 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-04-01 Epub Date: 2025-01-20 DOI: 10.1177/09564624251314567
Tanyanop Techasupaboon, Worapong Nasomsong

Cytomegalovirus (CMV) pneumonia is an uncommon presentation of CMV among patients with HIV/AIDS, particularly in co-infection with Pneumocystis jirovecii pneumonia (PCP). A case was reported with a literature review, and a comprehensive literature search was performed using the PubMed/MEDLINE and Scopus databases. We report a 52-year-old male with AIDS presenting with progressively worsening dyspnea over 1 week. One month earlier, he had completed a 21-day course of PCP treatment, showed improvement and was discharged. Two weeks before presentation, he started antiretroviral therapy (ART), but his dyspnea worsened significantly 1 week later. Chest radiography showed bilateral ground glass opacities. Bronchoscopy and lung biopsy revealed nuclear enlargement with prominent intranuclear inclusions and marginated chromatin of alveolar cells on H&E staining, along with positive immunohistochemistry for CMV. Grocott's methenamine silver staining identified 3-5 μm irregular yeast-like organisms resembling crushed ping-pong balls, consistent with P. jirovecii. He was treated with intravenous ganciclovir for a total of 21 days, and his clinical and radiologic findings completely resolved. CMV pneumonia co-infection with PCP is extremely rare and should be considered among patients with severely immunocompromise with interstitial pneumonitis unresponsive to PCP treatment or recurring after treatment.

巨细胞病毒(CMV)肺炎在HIV/AIDS患者中是一种罕见的巨细胞病毒表现,特别是在合并感染基罗氏肺囊虫肺炎(PCP)时。报告1例病例并进行文献综述,使用PubMed/MEDLINE和Scopus数据库进行全面的文献检索。我们报告一名52岁男性爱滋病患者,在1周内出现渐进式恶化的呼吸困难。一个月前,他完成了21天的PCP治疗,病情有所改善并出院。发病前两周,他开始抗逆转录病毒治疗(ART),但1周后他的呼吸困难明显恶化。胸片显示双侧磨玻璃影。支气管镜检查和肺活检显示核增大,核内包涵体明显,H&E染色肺泡细胞染色质边缘,CMV免疫组化阳性。Grocott的甲基苯丙胺银染色鉴定出3-5 μm的不规则酵母样生物,类似于压碎的乒乓球,与p.j roveci一致。他静脉注射更昔洛韦共21天,他的临床和放射学表现完全解决。巨细胞病毒肺炎合并PCP极为罕见,在对PCP治疗无反应或治疗后复发的严重免疫功能低下的间质性肺炎患者中应予以考虑。
{"title":"<i>Pneumocystis jirovecii</i> pneumonia co-infection with cytomegalovirus pneumonia in a patient with acquired immunodeficiency syndrome: A case report and literature review.","authors":"Tanyanop Techasupaboon, Worapong Nasomsong","doi":"10.1177/09564624251314567","DOIUrl":"10.1177/09564624251314567","url":null,"abstract":"<p><p>Cytomegalovirus (CMV) pneumonia is an uncommon presentation of CMV among patients with HIV/AIDS, particularly in co-infection with <i>Pneumocystis jirovecii</i> pneumonia (PCP). A case was reported with a literature review, and a comprehensive literature search was performed using the PubMed/MEDLINE and Scopus databases. We report a 52-year-old male with AIDS presenting with progressively worsening dyspnea over 1 week. One month earlier, he had completed a 21-day course of PCP treatment, showed improvement and was discharged. Two weeks before presentation, he started antiretroviral therapy (ART), but his dyspnea worsened significantly 1 week later. Chest radiography showed bilateral ground glass opacities. Bronchoscopy and lung biopsy revealed nuclear enlargement with prominent intranuclear inclusions and marginated chromatin of alveolar cells on H&E staining, along with positive immunohistochemistry for CMV. Grocott's methenamine silver staining identified 3-5 μm irregular yeast-like organisms resembling crushed ping-pong balls, consistent with <i>P</i>. <i>jirovecii</i>. He was treated with intravenous ganciclovir for a total of 21 days, and his clinical and radiologic findings completely resolved. CMV pneumonia co-infection with PCP is extremely rare and should be considered among patients with severely immunocompromise with interstitial pneumonitis unresponsive to PCP treatment or recurring after treatment.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"416-422"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymptomatic viral shedding of mpox virus: What do we know?
IF 1.4 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-04-01 DOI: 10.1177/09564624251332716
Sara Almarzooqi
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引用次数: 0
Duration of kissing in different intimate positions among men who have sex with men: A cross-sectional study. 男男性行为者以不同亲密姿势接吻的持续时间:一项横断面研究。
IF 1.4 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-04-01 Epub Date: 2024-11-19 DOI: 10.1177/09564624241301490
Julien Tran, Christopher K Fairley, Jason J Ong, Catriona S Bradshaw, Ei T Aung, Kate Maddaford, Marcus Y Chen, Jane S Hocking, Eric Pf Chow

BackgroundDespite mounting evidence showing that kissing (tongue-kissing) may transmit gonorrhoea between men who have sex with men (MSM), little data exists on factors influencing the duration of kissing while they are above and/or lying underneath a partner for this population group.MethodsBetween May 2019 and March 2020, we invited MSM aged ≥18 years who attended the Melbourne Sexual Health Centre (MSHC) to participate in a survey about the duration of their kissing (minutes) and intimate position while kissing (i.e., kissing while above, or while lying underneath) their most recent partner. Univariable and multivariable negative binomial regressions were performed to examine the associations between the duration of kissing in different intimate positions, and demographic and behavioural characteristics (including age, region of birth, HIV status or PrEP use, and role in anal sex).ResultsOf the 965 men with a recent male kissing partner, 89.0% (n = 859) also had sex with that partner. Of the 166 men with a recent female kissing partner, 71.7% (n = 119) also had sex with that partner. Our adjusted analyses showed that, on average, men born in Asia (mean 8.52 vs 11.69 min, p < .001) and South America or the Caribbean (mean 8.61 vs 11.69 min, p = .022) spent less time kissing compared to men born in Oceania, and the same was also observed for kissing while above or lying underneath. Men who had only receptive anal sex spent less time kissing while above than those who only had insertive anal sex (mean 3.04 vs 5.86 min, p < .001).ConclusionOur study is the first to examine factors that influence duration of kissing in different intimate positions. These factors could be associated with oropharyngeal gonorrhoea if saliva transmitted gonorrhoea and if gravity played a role.

背景:尽管有越来越多的证据表明,接吻(舌吻)可能会在男男性行为者(MSM)之间传播淋病,但关于影响该人群在伴侣上方和/或躺在伴侣下方时接吻持续时间的因素的数据却很少:2019年5月至2020年3月期间,我们邀请墨尔本性健康中心(MSHC)就诊的≥18岁的男男性行为者参与一项调查,了解他们与最近的性伴侣接吻的持续时间(分钟)和接吻时的亲密姿势(即在上方接吻或躺在下方接吻)。我们进行了单变量和多变量负二项回归,以研究不同亲密姿势下的接吻持续时间与人口统计学特征和行为特征(包括年龄、出生地区、HIV 感染状况或 PrEP 使用情况以及在肛交中的角色)之间的关联:在最近有男性接吻伴侣的 965 名男性中,89.0%(n = 859)还与该伴侣发生过性关系。在最近有女性接吻伴侣的 166 名男性中,71.7%(n = 119)的人也与该伴侣发生过性关系。我们的调整分析表明,与出生在大洋洲的男性相比,出生在亚洲(平均为 8.52 分钟 vs 11.69 分钟,p < .001)和南美洲或加勒比海地区(平均为 8.61 分钟 vs 11.69 分钟,p = .022)的男性平均接吻时间较短。只发生过接受性肛交的男性在上面接吻的时间比只发生过插入性肛交的男性少(平均 3.04 分钟 vs 5.86 分钟,p < .001):我们的研究首次探讨了影响不同亲密姿势下接吻时间的因素。结论:我们的研究首次探讨了影响不同亲密体位接吻持续时间的因素,如果唾液传播淋病,如果重力起作用,这些因素可能与口咽淋病有关。
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引用次数: 0
Increasing incidence of Mycoplasma genitalium is driven by people living with HIV and PrEP users. 生殖器支原体发病率的增加是由艾滋病毒感染者和PrEP使用者推动的。
IF 1.4 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-04-01 Epub Date: 2025-01-20 DOI: 10.1177/09564624251315782
Roberto Rossotti, Alice Nava, Federico D'Amico, Chiara Baiguera, Diana Fanti, Elvira Inglese, Alessandro Raimondi, Nicholas Brian Bana, Federico Spelzini, Maurizio Bini, Chiara Vismara, Massimo Puoti

BackgroundMycoplasma genitalium (MG) is responsible for non-gonococcal urethritis. Our aim is to describe MG positivity rate and incidence in specific populations.MethodsRetrospective, surveillance study included all samples collected from 2018 to 2022. All samples were tested with Anyplex II STI7 (Seegene). Incidence rate (IR) was calculated, incidence rate ratios (IRRs) were assessed using Poisson regression model.ResultsThe study included 13,504 samples belonging to 7,692 individuals. Overall positivity rate was 2.9% (95%CI 2.6-3.2). Subgroups showed significant differences: 13.6% in PrEP users, 5.2% in STI clinic, 4.6% in people living with HIV (PLWH), 1.2% in Gynecology/Obstetrics Department, 0.5% in Fertility clinic, and 0.5% in the "Other" group (p < .001). A significant increasing temporal trend was registered for PLWH. Over a cumulative follow up of 2,554 years, 293 incident infections were registered with an IR of 11.5 per 100PYFU. Departments showed diverse IRs: 7.9 per 100PYFU for PLWH, 30.1 per 100PYFU for PrEP users, 22.7 per 100PYFU for STI clinic. Poisson regression model found a significant increase in incident rates over time in the overall study population driven by PLWH and PrEP users.ConclusionsMG is uncommon in the general population with stable trends, while PLWH and PrEP users exhibit increasing positivity rate and incidence.

背景:生殖道支原体(MG)是导致非淋球菌性尿道炎的原因。我们的目的是描述MG在特定人群中的阳性率和发病率。方法:回顾性监测研究纳入2018 - 2022年收集的所有样本。所有样品均采用Anyplex II STI7 (Seegene)进行检测。计算发病率(IR),采用泊松回归模型评估发病率比(IRRs)。结果:该研究包括7692个人的13504个样本。总阳性率为2.9% (95%CI 2.6 ~ 3.2)。亚组差异显著:PrEP使用者占13.6%,STI诊所占5.2%,HIV感染者(PLWH)占4.6%,妇产科占1.2%,生育诊所占0.5%,“其他”组占0.5% (p < 0.001)。PLWH在时间上有显著的增加趋势。在2,554年的累计随访中,登记了293例事件感染,IR为11.5 / 100PYFU。各科室表现出不同的IRs:公共卫生部门为7.9 / 100PYFU, PrEP使用者为30.1 / 100PYFU,性传播感染诊所为22.7 / 100PYFU。泊松回归模型发现,在PLWH和PrEP使用者驱动的总体研究人群中,随着时间的推移,事故率显著增加。结论:MG在普通人群中少见,呈稳定趋势,而PLWH和PrEP使用者的阳性率和发病率呈上升趋势。
{"title":"Increasing incidence of <i>Mycoplasma genitalium</i> is driven by people living with HIV and PrEP users.","authors":"Roberto Rossotti, Alice Nava, Federico D'Amico, Chiara Baiguera, Diana Fanti, Elvira Inglese, Alessandro Raimondi, Nicholas Brian Bana, Federico Spelzini, Maurizio Bini, Chiara Vismara, Massimo Puoti","doi":"10.1177/09564624251315782","DOIUrl":"10.1177/09564624251315782","url":null,"abstract":"<p><p>Background<i>Mycoplasma genitalium</i> (MG) is responsible for non-gonococcal urethritis. Our aim is to describe MG positivity rate and incidence in specific populations.MethodsRetrospective, surveillance study included all samples collected from 2018 to 2022. All samples were tested with Anyplex II STI7 (Seegene). Incidence rate (IR) was calculated, incidence rate ratios (IRRs) were assessed using Poisson regression model.ResultsThe study included 13,504 samples belonging to 7,692 individuals. Overall positivity rate was 2.9% (95%CI 2.6-3.2). Subgroups showed significant differences: 13.6% in PrEP users, 5.2% in STI clinic, 4.6% in people living with HIV (PLWH), 1.2% in Gynecology/Obstetrics Department, 0.5% in Fertility clinic, and 0.5% in the \"Other\" group (<i>p</i> < .001). A significant increasing temporal trend was registered for PLWH. Over a cumulative follow up of 2,554 years, 293 incident infections were registered with an IR of 11.5 per 100PYFU. Departments showed diverse IRs: 7.9 per 100PYFU for PLWH, 30.1 per 100PYFU for PrEP users, 22.7 per 100PYFU for STI clinic. Poisson regression model found a significant increase in incident rates over time in the overall study population driven by PLWH and PrEP users.ConclusionsMG is uncommon in the general population with stable trends, while PLWH and PrEP users exhibit increasing positivity rate and incidence.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"381-387"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increasing new cases of mpox in Italy: From an epidemic infection to an endemic sexually transmitted disease? 意大利水痘新病例不断增加:从流行性传染病到地方性传染病?
IF 1.4 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1177/09564624251318444
Gionathan Orioni, Bianca Maria Piraccini, Valeria Gaspari
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引用次数: 0
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International Journal of STD & AIDS
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