Tumour Immunotherapy and Applications of Immunological Products: A Review of Literature.

IF 3.5 3区 医学 Q2 IMMUNOLOGY Journal of Immunology Research Pub Date : 2024-10-24 eCollection Date: 2024-01-01 DOI:10.1155/2024/8481761
Angus Nnamdi Oli, Samson Adedeji Adejumo, Adekunle Babajide Rowaiye, Joyce Oloaigbe Ogidigo, Jarrad Hampton-Marcell, Gordon C Ibeanu
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Abstract

Malignant tumors, characterized by uncontrolled cell proliferation, are a leading global health challenge, responsible for over 9.7 million deaths in 2022, with new cases expected to rise to 35 million annually by 2050. Immunotherapy is preferred to other cancer therapies, offering precise targeting of malignant cells while simultaneously strengthening the immune system's complex responses. Advances in this novel field of science have been closely linked to a deeper knowledge of tumor biology, particularly the intricate interplay between tumor cells, the immune system, and the tumor microenvironment (TME), which are central to cancer progression and immune evasion. This review offers a comprehensive analysis of the molecular mechanisms that govern these interactions, emphasizing their critical role in the development of effective immunotherapeutic products. We critically evaluate the current immunotherapy approaches, including cancer vaccines, adoptive T cell therapies, and cytokine-based treatments, highlighting their efficacy and safety. We also explore the latest advancements in combination therapies, which synergistically integrate multiple immunotherapeutic strategies to overcome resistance and enhance therapeutic outcomes. This review offers key insights into the future of cancer immunotherapy with a focus on advancing more effective and personalized treatment strategies.

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肿瘤免疫疗法和免疫产品的应用:文献综述。
恶性肿瘤以不受控制的细胞增殖为特征,是全球主要的健康挑战,2022 年造成 970 多万人死亡,预计到 2050 年,每年新增病例将增至 3500 万。与其他癌症疗法相比,免疫疗法更受青睐,因为它在精确靶向恶性细胞的同时,还能加强免疫系统的复杂反应。这一新颖科学领域的进展与对肿瘤生物学的深入了解密切相关,尤其是肿瘤细胞、免疫系统和肿瘤微环境(TME)之间错综复杂的相互作用,它们是癌症进展和免疫逃避的核心。本综述全面分析了这些相互作用的分子机制,强调了它们在开发有效免疫治疗产品中的关键作用。我们严格评估了当前的免疫疗法,包括癌症疫苗、收养 T 细胞疗法和基于细胞因子的疗法,重点介绍了它们的疗效和安全性。我们还探讨了联合疗法的最新进展,这种疗法能协同整合多种免疫治疗策略,克服抗药性并提高治疗效果。这篇综述为癌症免疫疗法的未来提供了重要见解,重点在于推进更有效的个性化治疗策略。
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来源期刊
CiteScore
6.90
自引率
2.40%
发文量
423
审稿时长
15 weeks
期刊介绍: Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
期刊最新文献
Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7. Virus-Triggered Autoimmunity Was Associated With Hirschsprung's Disease Through Activation of Innate Immunity. Tumour Immunotherapy and Applications of Immunological Products: A Review of Literature. Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases. Serum Levels of Selected Cytokines and Chemokines and IgG4 in Children With Recurrent Respiratory Tract Infections.
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