Topical Medroxyprogesterone Acetate and Corneal Epithelium Healing after Photorefractive Keratectomy: A Randomized, Double-masked Contralateral Eye Study.

IF 0.8 Q4 PHARMACOLOGY & PHARMACY Journal of Research in Pharmacy Practice Pub Date : 2024-09-26 eCollection Date: 2024-01-01 DOI:10.4103/jrpp.jrpp_26_24
Alireza Peyman, Mohsen Pourazizi, Matin Irajpour, Pegah Noorshargh, Asieh Aslani
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Abstract

Objective: The objective of the study was to evaluate the efficacy and safety of topical 1% medroxyprogesterone in corneal epithelial healing after photorefractive keratectomy (PRK).

Methods: In this placebo-controlled double-masked randomized contralateral eye study, 66 eyes of 33 patients with myopia and myopia-astigmatism were assigned into two groups to receive either 1% topical medroxyprogesterone (intervention) or artificial tear (placebo) at the end of PRK surgery. The patients were followed up daily for 5 days until epithelial healing was achieved. The time taken for epithelial healing was the main outcome measure.

Findings: The mean age of the subjects was 32.97 ± 7.6 years and 46 individuals were female (69.7%). All baseline refractive characteristics were comparable between the groups. There was no significant difference between the two groups in terms of epithelial defect size on Day 1 (P: 0.67). Both groups exhibited a consistent pattern of decreasing epithelial defect size from Day 1 to Day 5, with the control group having slightly worse initial values. There were no significant differences between the groups in the following days. Both groups showed substantial reductions in the epithelial defect size, but the intervention group showed a more prominent decrease on Day 2. The intervention did not show a significant statistical difference compared to the control group, and both groups ended up with a similar outcome.

Conclusion: These findings suggest that the topical 1% medroxyprogesterone does not significantly affect the healing of corneal epithelium after PRK.

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醋酸甲羟孕酮外用药与光屈光性角膜切除术后角膜上皮的愈合:一项随机、双掩蔽对侧眼研究。
研究目的该研究的目的是评估外用 1%甲羟孕酮对光屈光性角膜切除术(PRK)后角膜上皮愈合的有效性和安全性:在这项安慰剂对照双掩蔽随机对侧眼研究中,33 名近视和近视散光患者的 66 只眼睛被分为两组,在 PRK 手术结束后接受 1%甲羟孕酮(干预)或人工泪液(安慰剂)局部治疗。每天对患者进行为期 5 天的随访,直至上皮愈合。上皮愈合所需的时间是主要的结果测量指标:受试者的平均年龄为(32.97 ± 7.6)岁,其中 46 人为女性(69.7%)。两组的所有基线屈光特征均相当。第 1 天,两组的上皮缺损大小无明显差异(P:0.67)。从第 1 天到第 5 天,两组的上皮缺损面积均呈一致的下降趋势,对照组的初始值稍差。在接下来的几天里,两组之间没有明显差异。两组的上皮缺损面积都有大幅缩小,但干预组在第 2 天的缩小幅度更大。与对照组相比,干预组没有显示出明显的统计学差异,两组的结果相似:这些研究结果表明,外用 1%甲羟孕酮不会明显影响 PRK 术后角膜上皮的愈合。
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来源期刊
Journal of Research in Pharmacy Practice
Journal of Research in Pharmacy Practice PHARMACOLOGY & PHARMACY-
自引率
0.00%
发文量
8
审稿时长
21 weeks
期刊介绍: The main focus of the journal will be on evidence-based drug-related medical researches (with clinical pharmacists’ intervention or documentation), particularly in the Eastern Mediterranean region. However, a wide range of closely related issues will be also covered. These will include clinical studies in the field of pharmaceutical care, reporting adverse drug reactions and human medical toxicology, pharmaco-epidemiology and toxico-epidemiology (poisoning epidemiology), social aspects of pharmacy practice, pharmacy education and economic evaluations of treatment protocols (e.g. cost-effectiveness studies). Local reports of medication utilization studies at hospital or pharmacy levels will only be considered for peer-review process only if they have a new and useful message for the international pharmacy practice professionals and readers.
期刊最新文献
Association of Gestational Iron-deficiency Anemia with Antenatal Depression among Pregnant Women: A Case-control Study from Tertiary Care Hospitals, Lahore. Is there a Possible Association between Multiple Myeloma Relapse and Coronavirus Disease 2019 Vaccination? A Case Report. Pharmacists' Counseling and Benzodiazepines Dispensing for Sleep Disorders: A Simulated Patient Study in Iran. The Critical Role of Ward-Based and Satellite Pharmacists in Improving Pharmaceutical Care in Hospital. Topical Medroxyprogesterone Acetate and Corneal Epithelium Healing after Photorefractive Keratectomy: A Randomized, Double-masked Contralateral Eye Study.
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