Role of adenosine in the pathophysiology and treatment of attention deficit hyperactivity disorder.

IF 3 4区 医学 Q2 NEUROSCIENCES Purinergic Signalling Pub Date : 2024-10-31 DOI:10.1007/s11302-024-10059-2
Qingxia Jia, Hongwan Tan, Tingsong Li, Xiaoling Duan
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Abstract

Attention deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental condition characterized by persistent inattention, hyperactivity, and impulsivity. Although its precise etiology remains unclear, current evidence suggests that dysregulation within the neurotransmitter system plays a key role in the pathogenesis of ADHD. Adenosine, an endogenous nucleoside widely distributed throughout the body, modulates various physiological processes, including neurotransmitter release, sleep regulation, and cognitive functions through its receptors. This review critically examines the role of the adenosine system in ADHD, focusing on the links between adenosine receptor function and ADHD-related symptoms. Additionally, it explores how adenosine interacts with dopamine and other neurotransmitter pathways, shedding light on its involvement in ADHD pathophysiology. This review aims to provide insights into the potential therapeutic implications of targeting the adenosine system for ADHD management.

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腺苷在注意缺陷多动障碍的病理生理学和治疗中的作用。
注意缺陷多动障碍(ADHD)是一种复杂的神经发育疾病,其特征是持续的注意力不集中、多动和冲动。虽然其确切的病因尚不清楚,但目前的证据表明,神经递质系统失调在多动症的发病机制中起着关键作用。腺苷是一种广泛分布于人体各处的内源性核苷,可通过其受体调节各种生理过程,包括神经递质释放、睡眠调节和认知功能。本综述批判性地研究了腺苷系统在多动症中的作用,重点关注腺苷受体功能与多动症相关症状之间的联系。此外,它还探讨了腺苷如何与多巴胺和其他神经递质通路相互作用,从而揭示腺苷在多动症病理生理学中的作用。本综述旨在深入探讨针对腺苷系统治疗多动症的潜在治疗意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Purinergic Signalling
Purinergic Signalling 医学-神经科学
CiteScore
6.60
自引率
17.10%
发文量
75
审稿时长
6-12 weeks
期刊介绍: Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules. ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems. Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified. Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.
期刊最新文献
Correction to: Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist. Machine learning-aided search for ligands of P2Y6 and other P2Y receptors. Purinergic regulation of pulmonary vascular tone. Role of ecto-5'-nucleotidase in bladder function activity and smooth muscle contractility. Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia.
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