The role of antibody-dependent enhancement in dengue vaccination.

IF 2.4 Q3 INFECTIOUS DISEASES Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2024-11-01 DOI:10.1186/s40794-024-00231-2
D G Aynekulu Mersha, I van der Sterren, L P M van Leeuwen, T Langerak, M S Hakim, B Martina, S F L van Lelyveld, E C M van Gorp
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Abstract

Dengue is the most rapidly spreading vector-borne disease worldwide, with over half the global population at risk for an infection. Antibody-dependent enhancement (ADE) is associated with increased disease severity and may also be attributable to the deterioration of disease in vaccinated people. Two dengue vaccines are approved momentarily, with more in development. The increasing use of vaccines against dengue, combined with the development of more, makes a thorough understanding of the processes behind ADE more important than ever. Above that, due to the lack of treatment options, this method of prevention is of great importance. This review aims to explore the impact of ADE in dengue vaccinations, with the goal of enhancing potential vaccination strategies in the fight against dengue.

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抗体依赖性增强在登革热疫苗接种中的作用。
登革热是全球传播最迅速的病媒传染病,全球有一半以上的人口面临感染风险。抗体依赖性增强(ADE)与疾病严重程度的增加有关,也可能是疫苗接种者病情恶化的原因。目前已有两种登革热疫苗获得批准,还有更多疫苗正在研发中。随着登革热疫苗的使用越来越多,以及更多疫苗的开发,彻底了解 ADE 背后的过程比以往任何时候都更加重要。此外,由于缺乏治疗方法,这种预防方法也非常重要。本综述旨在探讨 ADE 在登革热疫苗接种中的影响,目的是在对抗登革热的斗争中加强潜在的疫苗接种策略。
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来源期刊
CiteScore
5.20
自引率
0.00%
发文量
25
审稿时长
17 weeks
期刊介绍: Tropical Diseases, Travel Medicine and Vaccines is an open access journal that considers basic, translational and applied research, as well as reviews and commentary, related to the prevention and management of healthcare and diseases in international travelers. Given the changes in demographic trends of travelers globally, as well as the epidemiological transitions which many countries are experiencing, the journal considers non-infectious problems including chronic disease among target populations of interest as well as infectious diseases.
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