Bigels as Novel Drug Delivery Systems: A Systematic Review on Efficiency and Influential Factors.

Shahrzad Shakouri, Mostafa Mazaheri Tehrani, Arash Koocheki, Reza Farhoosh, Anna Abdolshahi, Nabi Shariatifar
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Abstract

Background: Bigles are novel formulation merging two phase of hydrogel and organogel revealing dual properties to release active agents based on their lipophilic or hydrophilic nature.

Methods: A systematic search was conducted in PubMed, Scopus, and ISI Web of Science to find eligible studies evaluating the efficiency of bigels in drug release. 20 articles were included in the analysis based on the defined criteria.

Results: The results indicated that several different natural materials were used for bigel making. Span (52.38%) and Sunflower oil (23.80%) were the most solvents used for organogel formation. Also, gelatin, agar, gums, and other types of biopolymer were used as hydroglators. Most research (33.33%) focused on the release of metronidazole from bigel structure. Also, the range of drug release rates was 1.59 - 100% and in 42.85% of studies was >90%. The nature, content, and properties of both organogel and hydrogel and some process variables such as temperature, mixing speed and storage conditions were highlighted as the main influential factors on bigel formation and its bioactivity.

Conclusion: Bigels are an innovative structure that provides desired physicochemical and rheological properties for industrial applications. Excellent biocompatibility and in vitro / ex vivo results have been documented for developed bigels. In this regard, an optimal preparation method is very important to show superior therapeutic effects.

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作为新型给药系统的 Bigels:关于效率和影响因素的系统综述
背景:Bigles 是一种融合了水凝胶和有机凝胶两相的新型制剂,具有释放活性剂的双重特性:大凝胶是一种新型配方,融合了水凝胶和有机凝胶两相,具有双重特性,可根据活性剂的亲脂性或亲水性释放活性剂:方法: 在 PubMed、Scopus 和 ISI Web of Science 中进行了系统检索,以找到符合条件的评估 bigels 药物释放效率的研究。根据规定的标准,20 篇文章被纳入分析:结果表明,有几种不同的天然材料被用于制造大胶囊。司盘(52.38%)和葵花籽油(23.80%)是用于形成有机凝胶最多的溶剂。此外,明胶、琼脂、树胶和其他类型的生物聚合物也被用作水凝胶剂。大多数研究(33.33%)集中于甲硝唑从大凝胶结构中的释放。此外,药物释放率的范围在 1.59-100% 之间,42.85% 的研究大于 90%。有机凝胶和水凝胶的性质、含量和特性以及一些工艺变量,如温度、混合速度和储存条件,都是影响 bigel 形成及其生物活性的主要因素:大凝胶是一种创新结构,可为工业应用提供所需的物理化学和流变学特性。已开发的 bigels 具有出色的生物相容性和体外/体内结果。在这方面,最佳的制备方法对于显示卓越的治疗效果非常重要。
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来源期刊
CiteScore
4.80
自引率
9.10%
发文量
55
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