Distinguishing clinical and imaging characteristics of primary central nervous system lymphoma from high-grade glioma and metastatic brain tumors.

IF 2.8 3区医学 Q2 ONCOLOGY Clinical & Translational Oncology Pub Date : 2024-10-31 DOI:10.1007/s12094-024-03771-3

Qian Hu, Shenyang Zhang, Rui Xue Ma, Fengyi Lu, Qi Zhang, Jia Jing, Hafiz Khuram Raza, Shengli Li, Li Cheng, Zuohui Zhang, Lin He, Wenqing Meng, Hao Chen, Wei Chen

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Abstract

Objective: The purpose of this retrospective analysis was to evaluate the clinical presentations, radiological characteristics, patient outcomes, and therapeutic approaches among individuals diagnosed with primary central nervous system lymphoma (PCNSL), high-grade glioma (HGG), and metastatic brain tumors (METS).

Methods: We assembled a cohort of brain tumor patients from two medical centers, with two oncologists independently reviewing their clinical profiles. A retrospective examination of 87 PCNSL, 87 HGG, and 71 METS cases was performed to assess the aforementioned parameters.

Results: Notable variations were identified in the incidence of epileptic seizures and cognitive impairments between PCNSL and METS patients. Cerebral hemisphere involvement was predominantly observed in HGG and METS cases. PCNSL cases exhibited a higher likelihood of multiple lesions, whereas HGG showed a greater tendency for recurrence. The median survival times were established at 24.3 months for PCNSL, 44.5 months for HGG, and 27.1 months for METS patients. In PCNSL cases, the number of lesions was identified as a significant predictor of mortality (P = 0.008).

Conclusions: Our findings highlight the importance of clinical and imaging features in diagnosing PCNSL, which may present distinct features compared to HGG and METS.

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区分原发性中枢神经系统淋巴瘤与高级别胶质瘤和转移性脑肿瘤的临床和成像特征。

研究目的这项回顾性分析旨在评估原发性中枢神经系统淋巴瘤（PCNSL）、高级别胶质瘤（HGG）和转移性脑肿瘤（METS）患者的临床表现、放射学特征、患者预后和治疗方法：我们从两个医疗中心收集了一批脑肿瘤患者，由两名肿瘤学家独立审查他们的临床资料。我们对 87 例 PCNSL、87 例 HGG 和 71 例 METS 进行了回顾性检查，以评估上述参数：结果：在 PCNSL 和 METS 患者的癫痫发作率和认知障碍方面发现了明显的差异。在HGG和METS病例中主要观察到大脑半球受累。PCNSL 病例出现多个病灶的可能性更高，而 HGG 病例则更容易复发。PCNSL 患者的中位生存时间为 24.3 个月，HGG 患者为 44.5 个月，METS 患者为 27.1 个月。在 PCNSL 病例中，病灶数量被确定为死亡率的重要预测因素（P = 0.008）：我们的研究结果强调了临床和影像学特征在诊断 PCNSL 中的重要性，与 HGG 和 METS 相比，PCNSL 可能具有不同的特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical & Translational Oncology 医学-肿瘤学

CiteScore

6.20

自引率

2.90%

发文量

240

审稿时长

1 months

期刊介绍： Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.