Investigating the effects of cortico-cortical paired associative stimulation in the human brain: A systematic review and meta-analysis.

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-29 DOI:10.1016/j.neubiorev.2024.105933

Paolo Di Luzio, Laura Brady, Sonia Turrini, Vincenzo Romei, Alessio Avenanti, Alejandra Sel

{"title":"Investigating the effects of cortico-cortical paired associative stimulation in the human brain: A systematic review and meta-analysis.","authors":"Paolo Di Luzio, Laura Brady, Sonia Turrini, Vincenzo Romei, Alessio Avenanti, Alejandra Sel","doi":"10.1016/j.neubiorev.2024.105933","DOIUrl":null,"url":null,"abstract":"<p><p>Recent decades have witnessed a rapid development of novel neuromodulation techniques that allow direct manipulation of cortical pathways in the human brain. These techniques, known as cortico-cortical paired stimulation (ccPAS), apply magnetic stimulation over two cortical regions altering interregional connectivity. This review evaluates ccPAS's effectiveness to induce plastic changes in cortical pathways in the healthy brain. A systematic database search identified 41 studies investigating the effect of ccPAS on neurophysiological or behavioural measures, and a subsequent multilevel meta-analysis focused on the standardized mean differences to assess ccPAS's efficacy. Most studies report significant neurophysiological and behavioural changes from ccPAS interventions across several brain networks, consistently showing medium effect sizes. Moderator analyses revealed limited influence of experimental manipulations on effect sizes. The multivariate approach and lack of small-study bias suggest reliable effect estimates. ccPAS is a promising tool to manipulate neuroplasticity in cortical pathways, showing reliable effects on brain cortical networks. Important areas for further research on the influence of experimental procedures and the potential of ccPAS for clinical interventions are highlighted.</p>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":7.5000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscience and Biobehavioral Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neubiorev.2024.105933","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Recent decades have witnessed a rapid development of novel neuromodulation techniques that allow direct manipulation of cortical pathways in the human brain. These techniques, known as cortico-cortical paired stimulation (ccPAS), apply magnetic stimulation over two cortical regions altering interregional connectivity. This review evaluates ccPAS's effectiveness to induce plastic changes in cortical pathways in the healthy brain. A systematic database search identified 41 studies investigating the effect of ccPAS on neurophysiological or behavioural measures, and a subsequent multilevel meta-analysis focused on the standardized mean differences to assess ccPAS's efficacy. Most studies report significant neurophysiological and behavioural changes from ccPAS interventions across several brain networks, consistently showing medium effect sizes. Moderator analyses revealed limited influence of experimental manipulations on effect sizes. The multivariate approach and lack of small-study bias suggest reliable effect estimates. ccPAS is a promising tool to manipulate neuroplasticity in cortical pathways, showing reliable effects on brain cortical networks. Important areas for further research on the influence of experimental procedures and the potential of ccPAS for clinical interventions are highlighted.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

研究人脑皮层-皮层配对联想刺激的效果：系统回顾和荟萃分析。

近几十年来，可直接操控人脑皮质通路的新型神经调控技术发展迅速。这些技术被称为皮质-皮质配对刺激（ccPAS），通过对两个皮质区域进行磁刺激来改变区域间的连通性。本综述评估了 ccPAS 在诱导健康大脑皮质通路发生可塑性变化方面的有效性。通过系统性的数据库搜索，发现了 41 项研究调查了 ccPAS 对神经生理学或行为测量的影响，随后进行了多层次的荟萃分析，重点关注标准化平均差，以评估 ccPAS 的功效。大多数研究报告称，ccPAS干预措施在多个大脑网络中产生了明显的神经生理学和行为学变化，并持续显示出中等效应大小。调节分析显示，实验操作对效应大小的影响有限。ccPAS是操纵大脑皮层通路神经可塑性的一种有前途的工具，对大脑皮层网络有可靠的影响。实验程序的影响和ccPAS在临床干预方面的潜力是需要进一步研究的重要领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.