Neuroscience and Biobehavioral Reviews最新文献

Background: Binge eating (BE) involves consuming unusually large amounts of food within a short period and feeling a loss of control. Neurobiological mechanisms underlying BE involve dysregulation of reward and inhibitory control systems, with the endogenous opioid system playing a key role. Opioid antagonists and the combination therapies with bupropion may have potential to reduce BE by affecting the reward system, but evidence regarding their effectiveness remains inconclusive. This meta-analysis reviewed randomized controlled trials (RCTs) exploring the effects of opioid antagonists on BE frequency, BE severity, body weight, and mood.

Methods: We systematically searched PubMed, Embase, Cochrane CENTRAL, Web of Science, and ClinicalTrials.gov to identify RCTs published before May 14, 2023,. The primary outcomes were BE severity and frequency. The secondary outcomes were percentage change in body weight and depressive symptoms.

Results: Eight RCTs were included in our analysis. Opioid antagonists significantly reduced BE frequency (standard difference in means [SMD] = -0.624, 95 % confidence interval [CI] = -1.181 to -0.067, p = 0.028) and changes in body weight percentage (SMD = -0.981, 95 % CI = -1.657 to -0.305, p = 0.004), with a moderate-to-large effect size. Conversely, opioid antagonists didn't significantly improve BE severity (Hedges' g = -0.210, 95 % CI = -0.431 to 0.011, p = 0.063) or depressive symptoms (Hedges' g = -0.190, 95 % CI = -0.434 to 0.053, p = 0.125). Meta-regression analysis revealed that the dosage of naltrexone served as a moderator in reducing BE frequency and body weight percentage.

Conclusion: The present meta-analysis indicated that opioid antagonists effectively alleviate BE frequency and reduce percentage loss in body weight.

Metastability is proposed as the mechanism supporting our adaptive responses to the environment. While extensive research has characterized brain metastability during rest and task performance, prior studies have mainly focused on understanding underlying mechanisms, with limited exploration of its application in mental processes and behaviors. This scoping review offers an overview of the existing empirical literature in this area. Through a systematic search that included 36 articles, our results reveal a predominance of resting-state fMRI studies, variability in how metastability is defined, and a lack of consideration for common confounds in neuroimaging data. The review concludes with suggestions for future research directions to address crucial unresolved issues in the field.

Non-suicidal self-injury (NSSI) is a significant global mental health issue. However, whether the deficit in value-based decision-making processing is the consistently key mechanisms of NSSI across studies with heterogeneous decision-making tasks remains uncertain. Hence, we reviewed literature on value-based decision-making and its moderating factors in NSSI, and then conducted a meta-analysis on studies in NSSI, specifically with Iowa Gambling Task. In total, 31 studies with 8417 participants aged from 8 to 50 were included in the systematic review of and 8 studies with 657 participants aged from 10 to 37 included in the meta-analysis. We found consistent impairments in value-based decision-making processing among individuals who engage in NSSI. Importantly, age is a significant moderator, with adolescents with NSSI performance worse, exhibiting increased reward sensitivity and preference for immediate rewards compared to other age groups. These results suggest the important role of value-based decision making in NSSI behaviors, especially during the development of adolescents. Our work provides new insights and integrative evidence for decision-making based prevention and intervention of NSSI.