Comprehensive study of the physicochemical properties of three-component deep eutectic solvents and their implications for microbial and anticancerous activity

IF 3.2 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Journal of the Indian Chemical Society Pub Date : 2024-11-01 DOI:10.1016/j.jics.2024.101443
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Abstract

Sustainable chemistry centers on substituting perilous solvents and materials with eco-conscious alternatives. Deep eutectic solvents (DES) hold substantial potential in this arena. This inquiry includes the formulation of three-component eutectic solvents and an exhaustive scrutiny of their physical and chemical attributes. These encompass solubility, boiling point, pH, density, viscosity, surface tension, refractive index, contact angle, conductivity, Fourier-transform infrared spectroscopy, polarized optical microscopy, thermogravimetric analysis, and differential scanning calorimetry. Furthermore, a biological exploration featured two bacterial strains and two fungal strains. The entire spectrum of ten three-component DES was administered to these microorganisms to discern plausible impacts. In addition, the biomedical promise of these DES was unveiled through anticancer assays employing MCF-7 and HeLa cell lines. The outcomes were favorable, underscoring robust anticancer potency, thereby hinting at future oncological utility. These interdisciplinary endeavors envelop the progression of sustainable solvent innovation, meticulous physicochemical scrutiny, microbial analysis, and anticancer appraisal. This study propels inventive resolutions with ecological and biomedical reverberations by amalgamating these distinct yet interconnected facets.

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三组分深共晶溶剂理化性质及其对微生物和抗癌活性影响的综合研究
可持续化学的核心是用具有生态意识的替代品取代危险溶剂和材料。深共晶溶剂 (DES) 在这一领域具有巨大潜力。这项研究包括配制三组份共晶溶剂,并对其物理和化学属性进行详尽审查。这些属性包括溶解度、沸点、pH 值、密度、粘度、表面张力、折射率、接触角、电导率、傅立叶变换红外光谱、偏振光学显微镜、热重分析和差示扫描量热法。此外,还对两种细菌菌株和两种真菌菌株进行了生物学研究。对这些微生物施用了十种三组分 DES 的整个光谱,以确定其可能产生的影响。此外,还通过使用 MCF-7 和 HeLa 细胞系进行抗癌试验,揭示了这些 DES 的生物医学前景。结果良好,显示出强大的抗癌效力,从而为未来的肿瘤学用途埋下了伏笔。这些跨学科的努力涵盖了可持续溶剂创新、细致的物理化学检查、微生物分析和抗癌评估的进展。这项研究通过将这些不同但相互关联的方面结合起来,推动了具有生态和生物医学反响的发明性解决方案。
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来源期刊
CiteScore
3.50
自引率
7.70%
发文量
492
审稿时长
3-8 weeks
期刊介绍: The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.
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