Advancing electrochemical sensing: A smart platform for accurate CRP level detection in neonatal septicaemia

IF 4.1 Q1 CHEMISTRY, ANALYTICAL Talanta Open Pub Date : 2024-10-18 DOI:10.1016/j.talo.2024.100369
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Abstract

Neonatal septicaemia is an intricate systemic affliction induced in newborns. A multitude of fungi, viruses, and bacteria elicit this condition. Conventional methodologies such as radiological imaging, microbial testing, blood culture, and inflammatory markers suffer from an array of constraints for prompt detection of infection. This present study illustrates a cutting-edge smart electrochemical biosensing system. The fabricated system was meticulously engineered to discern the concentration of C-reactive protein (CRP). CRP is an irreplaceable prognostic indicator for neonatal sepsis. This work explicates the fabrication of a bioreceptor sensing platform (BioRe Sense) on a screen-printed miniaturized electrode. The surface of the electrode underwent modification with molybdenum disulfide nanosheets (MoS2NSs). Further, the interface was designed with molecularly imprinted polymer (MIP) targeting CRP. An electrochemical technique carefully examined the electrode at each modification stage. The created sensing interface can detect a wide concentration range from 0.01 nM to 100 nM, with a lower detection limit of 0.01 nM.
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推进电化学传感技术:用于准确检测新生儿败血症 CRP 水平的智能平台
新生儿败血症是新生儿诱发的一种复杂的全身性疾病。多种真菌、病毒和细菌都会引发这种疾病。传统的方法,如放射成像、微生物检测、血液培养和炎症标志物等,在及时检测感染方面受到一系列限制。本研究展示了一种先进的智能电化学生物传感系统。该系统经过精心设计,可识别 C 反应蛋白 (CRP) 的浓度。CRP 是新生儿败血症不可替代的预后指标。这项工作阐述了在丝网印刷微型电极上制作生物受体传感平台(BioRe Sense)的过程。电极表面经过二硫化钼纳米片(MoS2NSs)修饰。此外,还设计了针对 CRP 的分子印迹聚合物(MIP)界面。电化学技术仔细检查了每个修饰阶段的电极。所创建的传感界面可检测 0.01 nM 至 100 nM 的宽浓度范围,检测下限为 0.01 nM。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Talanta Open
Talanta Open Chemistry-Analytical Chemistry
CiteScore
5.20
自引率
0.00%
发文量
86
审稿时长
49 days
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