Pub Date : 2025-04-03DOI: 10.1016/j.talo.2025.100448
Favour Ezinne Ogulewe, Akeem Adeyemi Oladipo, Mustafa Gazi
Global health is significantly threatened by foodborne diseases and contaminants, highlighting the need for rapid, cost-effective detection methods. Molecularly imprinted polymers (MIPs) and metal-organic frameworks (MOFs) offer promising solutions, overcoming limitations of traditional analytical methods. This review examines the integration of MIPs and MOFs in electrochemical and fluorescence sensors for food analysis, detailing sensing mechanisms, performance factors, and electrode coating advancements. A significant portion of this review is dedicated to exploring the application of MIP and MOF-based sensors for the detection of a wide array of contaminants in food matrices, encompassing antibiotics, hormones, pesticides, mycotoxins, heavy metals, pathogenic microorganisms, food additives, and allergens. Despite progress, a comprehensive understanding of MIP/MOF-analyte interactions is crucial and remains a critical knowledge gap. This review critically analyses this gap, highlighting the imperative for further research aimed at elucidating these mechanisms to optimize sensor performance.
{"title":"Molecularly imprinted polymers and metal-organic framework-based nanomaterial sensors for food and beverage analysis and safety–A review","authors":"Favour Ezinne Ogulewe, Akeem Adeyemi Oladipo, Mustafa Gazi","doi":"10.1016/j.talo.2025.100448","DOIUrl":"10.1016/j.talo.2025.100448","url":null,"abstract":"<div><div>Global health is significantly threatened by foodborne diseases and contaminants, highlighting the need for rapid, cost-effective detection methods. Molecularly imprinted polymers (MIPs) and metal-organic frameworks (MOFs) offer promising solutions, overcoming limitations of traditional analytical methods. This review examines the integration of MIPs and MOFs in electrochemical and fluorescence sensors for food analysis, detailing sensing mechanisms, performance factors, and electrode coating advancements. A significant portion of this review is dedicated to exploring the application of MIP and MOF-based sensors for the detection of a wide array of contaminants in food matrices, encompassing antibiotics, hormones, pesticides, mycotoxins, heavy metals, pathogenic microorganisms, food additives, and allergens. Despite progress, a comprehensive understanding of MIP/MOF-analyte interactions is crucial and remains a critical knowledge gap. This review critically analyses this gap, highlighting the imperative for further research aimed at elucidating these mechanisms to optimize sensor performance.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100448"},"PeriodicalIF":4.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.talo.2025.100447
Maha Mohammad Abdel-Monem , Mohamed I. Walash , Asmaa Kamal El-Deen
The potential synergistic cardioprotective effects of resveratrol and doxorubicin combination have made precise analytical approaches necessary for determining their concentrations in human plasma. Herein, we propose a novel spectrofluorimetric method for the concurrent determination of resveratrol and doxorubicin in spiked human plasma using constant-wavelength synchronous fluorescence spectroscopy (CW-SFS) and fluorescence sensitization with metal chelating agent. By taking the advantage of synchronous scan mode, the CW-SFS can simultaneously scan the emission and excitation wavelengths with a fixed wavelength difference (Δλ = 80 nm), eliminating spectral interference and improving selectivity and sensitivity in the process. To further enhance sensitivity, the fluorescence sensitization method with a metal chelating agent was applied, where the fluorescence signal of both drugs is greatly amplified by adding Al3+and diluting with ethanol, improving the detection limits. The new approach shows low limits of detection (LODs) and quantification (LOQs), with excellent linearity (R2 > 0.999) over a wide concentration range of 10–1000 and 5–700 ng/mL for doxorubicin and resveratrol, respectively. The method was successfully applied to determine both drugs in spiked human plasma along with a holistic sustainability assessment. This innovative analytical method has the potential to be used in therapeutic drug monitoring, thereby facilitating the optimization of doxorubicin and resveratrol combination therapy for enhanced outcomes in therapeutic drug monitoring.
{"title":"Innovative metal-sensitized spectrofluorimetric method for the simultaneous determination of resveratrol and doxorubicin in human plasma: A holistic sustainability appraisal","authors":"Maha Mohammad Abdel-Monem , Mohamed I. Walash , Asmaa Kamal El-Deen","doi":"10.1016/j.talo.2025.100447","DOIUrl":"10.1016/j.talo.2025.100447","url":null,"abstract":"<div><div>The potential synergistic cardioprotective effects of resveratrol and doxorubicin combination have made precise analytical approaches necessary for determining their concentrations in human plasma. Herein, we propose a novel spectrofluorimetric method for the concurrent determination of resveratrol and doxorubicin in spiked human plasma using constant-wavelength synchronous fluorescence spectroscopy (CW-SFS) and fluorescence sensitization with metal chelating agent. By taking the advantage of synchronous scan mode, the CW-SFS can simultaneously scan the emission and excitation wavelengths with a fixed wavelength difference (Δλ = 80 nm), eliminating spectral interference and improving selectivity and sensitivity in the process. To further enhance sensitivity, the fluorescence sensitization method with a metal chelating agent was applied, where the fluorescence signal of both drugs is greatly amplified by adding Al<sup>3+</sup>and diluting with ethanol, improving the detection limits. The new approach shows low limits of detection (LODs) and quantification (LOQs), with excellent linearity (<em>R<sup>2</sup></em> > 0.999) over a wide concentration range of 10–1000 and 5–700 ng/mL for doxorubicin and resveratrol, respectively. The method was successfully applied to determine both drugs in spiked human plasma along with a holistic sustainability assessment. This innovative analytical method has the potential to be used in therapeutic drug monitoring, thereby facilitating the optimization of doxorubicin and resveratrol combination therapy for enhanced outcomes in therapeutic drug monitoring.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100447"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The gradually growing demand for the sensitive, selective and eco-friendly approaches for pharmaceutical detection has driven significant prograsses in molecularly imprinted polymer (MIP)-based sensing platforms. MIPs, known for their high specificity and robustness, have emerged as promising materials for the design and constrcution of eco-friendly sensing platforms capable of detecting pharmaceuticals in complex matrices. This review paper provides a comprehensive review of recent advances in the design, fabrication and application of eco-friendly MIP-based sensing platforms, with a focus on their eco-friendly and sustainable features and analytical performance. Furthermore, key apprıaches such as the incorporation of green synthesis methods, renewable resources and eco-friendly polymerization techniques are highlighted.
{"title":"Eco-friendly molecularly imprinted polymer-based sensing platforms towards pharmaceuticals: recent advances and future prospects","authors":"Rüstem Keçili , Ghazanfar Hussain , Chaudhery Mustansar Hussain , Adil Denizli","doi":"10.1016/j.talo.2025.100446","DOIUrl":"10.1016/j.talo.2025.100446","url":null,"abstract":"<div><div>The gradually growing demand for the sensitive, selective and eco-friendly approaches for pharmaceutical detection has driven significant prograsses in molecularly imprinted polymer (MIP)-based sensing platforms. MIPs, known for their high specificity and robustness, have emerged as promising materials for the design and constrcution of eco-friendly sensing platforms capable of detecting pharmaceuticals in complex matrices. This review paper provides a comprehensive review of recent advances in the design, fabrication and application of eco-friendly MIP-based sensing platforms, with a focus on their eco-friendly and sustainable features and analytical performance. Furthermore, key apprıaches such as the incorporation of green synthesis methods, renewable resources and eco-friendly polymerization techniques are highlighted.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100446"},"PeriodicalIF":4.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-29DOI: 10.1016/j.talo.2025.100445
Sathya Jyothi N V , Revathi V , Chakradhar Sridhar B , Yogesh Kumar K , Prashanth M K , Fahd Alharethy , Byong-Hun Jeon , Raghu M S
Fenitrothion (FNT), a commonly used organophosphorus pesticide used in agriculture poses numerous health hazards to living beings and the environment. Therefore, monitoring the dosage of FNT in agriculture is becoming increasingly important. The current work aims to develop an electrochemical sensor for the sensitive detection of FNT. A simple green method using avocado seed extract as a reducing agent has been developed for the synthesis of spinel-structured Mg2SnO4 (MSO), which is combined with polyaniline (PANI) to generate the MSO/PANI nanocomposite. Glassy carbon electrode (GCE) was modified using MSO, PANI and MSO/PANI were examined for electrochemical performance using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. Superior electrochemical performance is observed in MSO/PANI-modified GCE compared to MSO and PANI-modified GCE. Superior activity in MSO/PANI could be attributed to the improved electroactive sites, conductivity, and easy electron exchange at the electron/electrode system. FNT detection was carried out using different electrodes and found to show a wide range of detection (0.01 to 390 µM) using DPV with a 0.04 nM limit of detection (LOD). FNT detection was pursued in the presence of grapes and river water and the percentage recovery is in between 97.1 to 99.1. MSO/PANI has been used as electrode material and found to exhibit specific capacitance of 695 F g-1 at a scan rate of 10 mV s⁻¹. Good recyclability, superior performance, stability, and real sample performance make MSO/PANI a material of choice towards electrochemical performance as a sensor and supercapacitor and serve towards sustainability towards the environment, health, and energy.
{"title":"Fabrication of spinel magnesium stannate-polyaniline nanocomposite for electrochemical detection of fenitrothion pesticide and supercapacitor applications","authors":"Sathya Jyothi N V , Revathi V , Chakradhar Sridhar B , Yogesh Kumar K , Prashanth M K , Fahd Alharethy , Byong-Hun Jeon , Raghu M S","doi":"10.1016/j.talo.2025.100445","DOIUrl":"10.1016/j.talo.2025.100445","url":null,"abstract":"<div><div>Fenitrothion (FNT), a commonly used organophosphorus pesticide used in agriculture poses numerous health hazards to living beings and the environment. Therefore, monitoring the dosage of FNT in agriculture is becoming increasingly important. The current work aims to develop an electrochemical sensor for the sensitive detection of FNT. A simple green method using avocado seed extract as a reducing agent has been developed for the synthesis of spinel-structured Mg<sub>2</sub>SnO<sub>4</sub> (MSO), which is combined with polyaniline (PANI) to generate the MSO/PANI nanocomposite. Glassy carbon electrode (GCE) was modified using MSO, PANI and MSO/PANI were examined for electrochemical performance using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. Superior electrochemical performance is observed in MSO/PANI-modified GCE compared to MSO and PANI-modified GCE. Superior activity in MSO/PANI could be attributed to the improved electroactive sites, conductivity, and easy electron exchange at the electron/electrode system. FNT detection was carried out using different electrodes and found to show a wide range of detection (0.01 to 390 µM) using DPV with a 0.04 nM limit of detection (LOD). FNT detection was pursued in the presence of grapes and river water and the percentage recovery is in between 97.1 to 99.1. MSO/PANI has been used as electrode material and found to exhibit specific capacitance of 695 F g<sup>-1</sup> at a scan rate of 10 mV s⁻¹. Good recyclability, superior performance, stability, and real sample performance make MSO/PANI a material of choice towards electrochemical performance as a sensor and supercapacitor and serve towards sustainability towards the environment, health, and energy.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100445"},"PeriodicalIF":4.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-25DOI: 10.1016/j.talo.2025.100444
Sibel Büyüktiryaki
Accurate and reliable detection of cancer biomarkers plays a pivotal role in early diagnosis, disease progression monitoring, and effective treatment strategies. Molecularly imprinted polymers (MIPs), with their high selectivity and stability, have emerged as powerful tools for biomarker detection. This review explores the fundamental principles of MIPs and their tailored synthesis for biological markers. Special emphasis is placed on integrating MIPs with analytical techniques such as optical and electrochemical sensing platforms. Moreover, it highlights their success in real biological matrices and addresses the challenges and opportunities for developing advanced solutions. Finally, the review addresses challenges and future directions, emphasizing the critical role of MIP technology in achieving ultra-sensitive, cost-effective, and portable diagnostic solutions. This review aims to highlight the potential of MIP-based sensors for the selective and sensitive detection of cancer biomarkers and to serve as a guide for researchers in the field.
{"title":"Sensitive and selective detection of cancer biomarkers with molecularly imprinted biosensors","authors":"Sibel Büyüktiryaki","doi":"10.1016/j.talo.2025.100444","DOIUrl":"10.1016/j.talo.2025.100444","url":null,"abstract":"<div><div>Accurate and reliable detection of cancer biomarkers plays a pivotal role in early diagnosis, disease progression monitoring, and effective treatment strategies. Molecularly imprinted polymers (MIPs), with their high selectivity and stability, have emerged as powerful tools for biomarker detection. This review explores the fundamental principles of MIPs and their tailored synthesis for biological markers. Special emphasis is placed on integrating MIPs with analytical techniques such as optical and electrochemical sensing platforms. Moreover, it highlights their success in real biological matrices and addresses the challenges and opportunities for developing advanced solutions. Finally, the review addresses challenges and future directions, emphasizing the critical role of MIP technology in achieving ultra-sensitive, cost-effective, and portable diagnostic solutions. This review aims to highlight the potential of MIP-based sensors for the selective and sensitive detection of cancer biomarkers and to serve as a guide for researchers in the field.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100444"},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-25DOI: 10.1016/j.talo.2025.100443
Luiz R.G. Silva , Domingos R. Santos-Neto , Jéssica S. Stefano , Daniel H. de Oliveira , Larissa S. da Silva , Heloysa S. Pittner , Cíntia L. Handa , Rodrigo A.A. Muñoz , Diego P. Rocha
Nitrite (NO2ˉ) is an essential compound present in various processes in nature, which ranges from environmental to biological systems. It is widely used in both food and chemical industry, and even in the production of medicines. However, the excess of NO2ˉ can cause severe damage to both the environment and human health. With this concern, this work presents a novel and easy to produce platform, entirely projected and constructed by additive manufacturing, rising a miniaturized and portable electrochemical system for the determination of NO2ˉ in water and synthetic saliva samples. The set of three electrodes was easily obtained by fused deposition modeling, using a carbon black-based filament feeding the 3D printer. The surface of the electrochemical sensors was treated to expose conductive particles and enhance their electrochemical performance. The differential-pulse voltammetry technique was meticulously chosen and fully optimized using multivariate methods to achieve the best operational conditions for the NO2ˉ determination. The proposed method presented a linear dynamic range from 5.0 to 500.0 µmol L⁻¹, with a limit of detection of 1.8 µmol L⁻¹. Besides, interference tests demonstrated a good selectivity of the method. Recovery values close to 100 % for water and simulated saliva samples demonstrate the applicability of the developed method. In this context, the 3D-printed electrochemical device becomes a potential alternative for the on-site, reliable, and fast determination of NO2ˉ.
{"title":"3D-printed electrochemical sensor applied to the determination of nitrite: A cost-effective and portable platform for environmental and clinical monitoring","authors":"Luiz R.G. Silva , Domingos R. Santos-Neto , Jéssica S. Stefano , Daniel H. de Oliveira , Larissa S. da Silva , Heloysa S. Pittner , Cíntia L. Handa , Rodrigo A.A. Muñoz , Diego P. Rocha","doi":"10.1016/j.talo.2025.100443","DOIUrl":"10.1016/j.talo.2025.100443","url":null,"abstract":"<div><div>Nitrite (NO<sub>2</sub><sup>ˉ</sup>) is an essential compound present in various processes in nature, which ranges from environmental to biological systems. It is widely used in both food and chemical industry, and even in the production of medicines. However, the excess of NO<sub>2</sub><sup>ˉ</sup> can cause severe damage to both the environment and human health. With this concern, this work presents a novel and easy to produce platform, entirely projected and constructed by additive manufacturing, rising a miniaturized and portable electrochemical system for the determination of NO<sub>2</sub><sup>ˉ</sup> in water and synthetic saliva samples. The set of three electrodes was easily obtained by fused deposition modeling, using a carbon black-based filament feeding the 3D printer. The surface of the electrochemical sensors was treated to expose conductive particles and enhance their electrochemical performance. The differential-pulse voltammetry technique was meticulously chosen and fully optimized using multivariate methods to achieve the best operational conditions for the NO<sub>2</sub><sup>ˉ</sup> determination. The proposed method presented a linear dynamic range from 5.0 to 500.0 µmol L<sup>⁻¹</sup>, with a limit of detection of 1.8 µmol L<sup>⁻¹</sup>. Besides, interference tests demonstrated a good selectivity of the method. Recovery values close to 100 % for water and simulated saliva samples demonstrate the applicability of the developed method. In this context, the 3D-printed electrochemical device becomes a potential alternative for the on-site, reliable, and fast determination of NO<sub>2</sub><sup>ˉ</sup>.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100443"},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-25DOI: 10.1016/j.talo.2025.100430
Deeksha Nautiyal, Utkarsh Jain
Optical biosensors doped with nanomaterials are the most technologically advanced in viral diagnostics, showing higher sensitivity, specificity, and speed of detection. This review describes the role of fluorescent and quenching nanomaterials in the development of optical biosensing techniques. These sensors enable real-time, non-invasive viral detection with minimal preparation of samples by exploiting unique optical properties of nanomaterials, such as increased fluorescence, efficient energy transfer, and significant signal amplification. It is worth noting that the material's application in point-of-care settings effectively bridges laboratory accuracy with the practical applicability of real-world applications. Moreover, these aspects were put into review, along with the latest advancements in the emerging dual-functional nanocomposites able to integrate the fluorescence and quenching mechanisms for multimodal detection, with emphasis on what has been recently achieved and how these efforts have been developed to tackle stability, reproducibility, and scalability concerns. This will enable optical biosensing through advances in nanotechnology and pave the way for designing next-generation diagnostic platforms capable of addressing current and emerging viral threats.
{"title":"Emerging Trends in Fluorescent and Quenching Nanomaterials for Viral detection: Innovations in Biological and Chemical sensing","authors":"Deeksha Nautiyal, Utkarsh Jain","doi":"10.1016/j.talo.2025.100430","DOIUrl":"10.1016/j.talo.2025.100430","url":null,"abstract":"<div><div>Optical biosensors doped with nanomaterials are the most technologically advanced in viral diagnostics, showing higher sensitivity, specificity, and speed of detection. This review describes the role of fluorescent and quenching nanomaterials in the development of optical biosensing techniques. These sensors enable real-time, non-invasive viral detection with minimal preparation of samples by exploiting unique optical properties of nanomaterials, such as increased fluorescence, efficient energy transfer, and significant signal amplification. It is worth noting that the material's application in point-of-care settings effectively bridges laboratory accuracy with the practical applicability of real-world applications. Moreover, these aspects were put into review, along with the latest advancements in the emerging dual-functional nanocomposites able to integrate the fluorescence and quenching mechanisms for multimodal detection, with emphasis on what has been recently achieved and how these efforts have been developed to tackle stability, reproducibility, and scalability concerns. This will enable optical biosensing through advances in nanotechnology and pave the way for designing next-generation diagnostic platforms capable of addressing current and emerging viral threats.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100430"},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-25DOI: 10.1016/j.talo.2025.100442
Rashmi M, Samrat Devaramani
Herein we report a simple one-step strategy for surface modification of copper electrode stickers for the fabrication of copper-based paper electrochemical sensing device (Cu-PESD). Taking advantage of conducting adhesive on the copper tape, the scotch tape method is adopted to modify the adhesive surface. Pristine copper electrode stickers fabricated PESD can sense trace metal ions, but the modification of electrodes further improved sensitivity for simultaneous electroanalysis. Bi is selected as a modifier to demonstrate the simple scotch-tape modification strategy. The modified copper electrode stickers with Bi enabled the device to achieve peak resolution, sensitivity, and simultaneous electrochemical detection of Pb(II) and Cd(II). The bismuth-modified copper-based PESD (Bi-Cu-PESD) exhibited the linear range from 0.2 to 12 mg L−1 for simultaneous detection of Pb(II) and Cd(II) ions. The limit of detection was 0.078 mg L−1 and 0.183 mg L−1 for Pb(II) and Cd(II) respectively. Modified electrode stickers were characterized to study the electrode crystallinity, surface morphology, and elemental composition using XRD, SEM, and EDS respectively. The potential of the fabricated PESD was tested by quantifying Pb(II) and Cd(II) ions in the water samples. The electrochemical results were in agreement with the standard AAS method.
{"title":"Scotch tape method like modification of electrode stickers: Bismuth-modified copper-based paper device for simultaneous electrochemical detection of Pb(II) and Cd(II)","authors":"Rashmi M, Samrat Devaramani","doi":"10.1016/j.talo.2025.100442","DOIUrl":"10.1016/j.talo.2025.100442","url":null,"abstract":"<div><div>Herein we report a simple one-step strategy for surface modification of copper electrode stickers for the fabrication of copper-based paper electrochemical sensing device (Cu-PESD). Taking advantage of conducting adhesive on the copper tape, the scotch tape method is adopted to modify the adhesive surface. Pristine copper electrode stickers fabricated PESD can sense trace metal ions, but the modification of electrodes further improved sensitivity for simultaneous electroanalysis. Bi is selected as a modifier to demonstrate the simple scotch-tape modification strategy. The modified copper electrode stickers with Bi enabled the device to achieve peak resolution, sensitivity, and simultaneous electrochemical detection of Pb(II) and Cd(II). The bismuth-modified copper-based PESD (Bi-Cu-PESD) exhibited the linear range from 0.2 to 12 mg <em>L</em><sup>−1</sup> for simultaneous detection of Pb(II) and Cd(II) ions. The limit of detection was 0.078 mg <em>L</em><sup>−1</sup> and 0.183 mg <em>L</em><sup>−1</sup> for Pb(II) and Cd(II) respectively. Modified electrode stickers were characterized to study the electrode crystallinity, surface morphology, and elemental composition using XRD, SEM, and EDS respectively. The potential of the fabricated PESD was tested by quantifying Pb(II) and Cd(II) ions in the water samples. The electrochemical results were in agreement with the standard AAS method.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100442"},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-24DOI: 10.1016/j.talo.2025.100441
Raíssa R.D. Brum , Lucas V. de Faria , Natalia M. Caldas , Robson P. Pereira , Diego A. Peixoto , Samuel C. Silva , Edson Nossol , Felipe S. Semaan , Wagner F. Pacheco , Diego P. Rocha , Rafael M. Dornellas
The detection of explosives is of great importance in the forensic scenario. For this reason, we proposed a lab-made graphite/alumina/polylactic acid (G/Al2O3/PLA)-based 3D-printed electrode for 2,4,6-trinitrotoluene (TNT) electrochemical determination. The material was characterized by infrared and Raman spectroscopy, scanning electron microscopy, and energy dispersion X-ray spectra, indicating that G and Al2O3 were incorporated into the PLA matrix. The proposed electrode combined with the square wave voltammetry (SWV) technique, demonstrated the ability to detect TNT residues, where the first reduction process around -0.24 V was monitored for the analyses. The developed electrochemical strategy supplied a linear range between 0.5 – 6.0 µmol L-1 and a detection limit of 0.071 µmol L-1. The method's applicability was tested on real samples of tap, lagoon, and seawater by direct analysis. Recovery values in the 100 to 106% range were obtained, representing adequate accuracy. The lab-made electrode was also utilized as a sampler to collect TNT residues on different surfaces, enabling the detection of TNT levels in the nanogram range and demonstrating the electrode's exceptional ability to detect trace amounts of the compound. These results reinforce the device's potential as a viable alternative for fast, accurate, and low-cost analysis in practical situations.
{"title":"3D-printed electrochemical sensor based on graphite-alumina composites: A sensitive and reusable platform for self-sampling and detection of 2,4,6-trinitrotoluene residues in environmental and forensic applications","authors":"Raíssa R.D. Brum , Lucas V. de Faria , Natalia M. Caldas , Robson P. Pereira , Diego A. Peixoto , Samuel C. Silva , Edson Nossol , Felipe S. Semaan , Wagner F. Pacheco , Diego P. Rocha , Rafael M. Dornellas","doi":"10.1016/j.talo.2025.100441","DOIUrl":"10.1016/j.talo.2025.100441","url":null,"abstract":"<div><div>The detection of explosives is of great importance in the forensic scenario. For this reason, we proposed a lab-made graphite/alumina/polylactic acid (G/Al<sub>2</sub>O<sub>3</sub>/PLA)-based 3D-printed electrode for 2,4,6-trinitrotoluene (TNT) electrochemical determination. The material was characterized by infrared and Raman spectroscopy, scanning electron microscopy, and energy dispersion X-ray spectra, indicating that G and Al<sub>2</sub>O<sub>3</sub> were incorporated into the PLA matrix. The proposed electrode combined with the square wave voltammetry (SWV) technique, demonstrated the ability to detect TNT residues, where the first reduction process around -0.24 V was monitored for the analyses. The developed electrochemical strategy supplied a linear range between 0.5 – 6.0 µmol L<sup>-1</sup> and a detection limit of 0.071 µmol L<sup>-1</sup>. The method's applicability was tested on real samples of tap, lagoon, and seawater by direct analysis. Recovery values in the 100 to 106% range were obtained, representing adequate accuracy. The lab-made electrode was also utilized as a sampler to collect TNT residues on different surfaces, enabling the detection of TNT levels in the nanogram range and demonstrating the electrode's exceptional ability to detect trace amounts of the compound. These results reinforce the device's potential as a viable alternative for fast, accurate, and low-cost analysis in practical situations.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100441"},"PeriodicalIF":4.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-22DOI: 10.1016/j.talo.2025.100439
Pinar Cakir Hatir , Alice Marinangeli , Alessandra Maria Bossi , Gokhan Cayli
Molecularly imprinted polymers (MIPs) are synthetic materials that selectively recognize target molecules, offering cost-effective and stable alternatives to antibodies. While MIP nanoparticles are ideal for biomedical applications for their high surface area and their biomolecule-compatible size, traditional monomers used in their synthesis can pose issues in biocompatibility. This study presents a sustainable approach to MIP nanoparticle production using acrylated methyl ricinoleate (AMR), a functional monomer derived from castor oil. These "GreenNanoMIPs" were designed to recognize cardiac troponin I (cTnI), a key biomarker for cardiovascular events. The nanoparticles, with an average size of 81 nm, exhibited exceptional homogeneity in suspension, with a low PDI value of 0.064, and outstanding stability, as no changes in particle size distribution or PDI were observed even after one year. GreenNanoMIPs did recognize the entire cTnI protein thorough the epitope approach. Furthermore, GreenNanoMIPs were successfully used for the detection of the cTnI biomarker directly in serum. The study highlights the potential of eco-friendly, biocompatible MIPs for applications in diagnostics, drug delivery, and environmental sensing.
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