Surface PEGylation of Poly(Ethylenimine) dendrimers grafted magnetic nanoparticles as a pH and magnetic targeting responsive system for Cytarabine drug delivery
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引用次数: 0
Abstract
A pH and magnetically dual responsive platform was synthesized by PEGylation of poly (ethylenimine) dendrimers grafted magnetic nanoparticles for targeted cytarabine delivery. Characterization techniques confirmed the platform structure and properties. Optimal drug adsorption occurred at pH 8, with an adsorbent dosage of 0.01 g, and 60 min of contact time at 298 K. Pseudo-second-order kinetic and Langmuir isotherm models best fit the adsorption data. The thermodynamic data shows that drug adsorption is a favorable and spontaneous process. Drug release rates were 61.45 % and 21.92 % at pH 5.6 and 7.4 over 6 h. The release kinetics followed Korsmeyer-Peppas model, showing non-Fickian behavior.
期刊介绍：
Chemical Physics Letters has an open access mirror journal, Chemical Physics Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Chemical Physics Letters publishes brief reports on molecules, interfaces, condensed phases, nanomaterials and nanostructures, polymers, biomolecular systems, and energy conversion and storage.
Criteria for publication are quality, urgency and impact. Further, experimental results reported in the journal have direct relevance for theory, and theoretical developments or non-routine computations relate directly to experiment. Manuscripts must satisfy these criteria and should not be minor extensions of previous work.
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