{"title":"Synthesis of a series of dextran-based DA-AHA hydrogels for wound healing dressings","authors":"","doi":"10.1016/j.eurpolymj.2024.113521","DOIUrl":null,"url":null,"abstract":"<div><div>In response to the pain, swelling, and redness resulting from inadequate wound hemostasis and anti-inflammatory measures, there is a pressing need to develop wound repair materials capable of promptly stopping bleeding, facilitating painless dressing changes, and expediting wound closure to enhance skin wound recovery. However, comprehensive research is deficient concerning the conformational relationship of hyaluronic acid (HA) with various molecular weights concerning the structure of hydrogel materials. This study aims to address this need by utilizing aminated hyaluronic acid (AHA) and aldehyde-modified dextran (DA) to prepare dextran-based hyaluronic acid hydrogels (DA-AHA) via Schiff base reaction, imbuing them with acute inflammation repair and wound healing promotion properties. In vitro, coagulation experiments demonstrated that the DA-AHA hydrogel could rapidly coagulate blood within 60 s. Subsequent animal experiments corroborated these findings, revealing the hydrogel’s efficacy in significantly shortening wound healing time and accelerating wound closure efficiency. Moreover, MTT and live-death experiments affirmed the non-cytotoxic nature of the synthesized hydrogel. The study delved into the structural regularity and wound-healing efficacy of DA-AHA hydrogel materials featuring various molecular weights. Additionally, it compared the hemostatic and wound-healing properties of (high molecular weight dextran-aminated hyaluronic acid hydrogel) HDA-AHA, demonstrating its superiority in both aspects.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":null,"pages":null},"PeriodicalIF":5.8000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Polymer Journal","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014305724007821","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
In response to the pain, swelling, and redness resulting from inadequate wound hemostasis and anti-inflammatory measures, there is a pressing need to develop wound repair materials capable of promptly stopping bleeding, facilitating painless dressing changes, and expediting wound closure to enhance skin wound recovery. However, comprehensive research is deficient concerning the conformational relationship of hyaluronic acid (HA) with various molecular weights concerning the structure of hydrogel materials. This study aims to address this need by utilizing aminated hyaluronic acid (AHA) and aldehyde-modified dextran (DA) to prepare dextran-based hyaluronic acid hydrogels (DA-AHA) via Schiff base reaction, imbuing them with acute inflammation repair and wound healing promotion properties. In vitro, coagulation experiments demonstrated that the DA-AHA hydrogel could rapidly coagulate blood within 60 s. Subsequent animal experiments corroborated these findings, revealing the hydrogel’s efficacy in significantly shortening wound healing time and accelerating wound closure efficiency. Moreover, MTT and live-death experiments affirmed the non-cytotoxic nature of the synthesized hydrogel. The study delved into the structural regularity and wound-healing efficacy of DA-AHA hydrogel materials featuring various molecular weights. Additionally, it compared the hemostatic and wound-healing properties of (high molecular weight dextran-aminated hyaluronic acid hydrogel) HDA-AHA, demonstrating its superiority in both aspects.
期刊介绍:
European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas:
Polymer synthesis and functionalization
• Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers.
Stimuli-responsive polymers
• Including shape memory and self-healing polymers.
Supramolecular polymers and self-assembly
• Molecular recognition and higher order polymer structures.
Renewable and sustainable polymers
• Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites.
Polymers at interfaces and surfaces
• Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications.
Biomedical applications and nanomedicine
• Polymers for regenerative medicine, drug delivery molecular release and gene therapy
The scope of European Polymer Journal no longer includes Polymer Physics.