Synthesis of a series of dextran-based DA-AHA hydrogels for wound healing dressings

IF 5.8 2区 化学 Q1 POLYMER SCIENCE European Polymer Journal Pub Date : 2024-10-28 DOI:10.1016/j.eurpolymj.2024.113521
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Abstract

In response to the pain, swelling, and redness resulting from inadequate wound hemostasis and anti-inflammatory measures, there is a pressing need to develop wound repair materials capable of promptly stopping bleeding, facilitating painless dressing changes, and expediting wound closure to enhance skin wound recovery. However, comprehensive research is deficient concerning the conformational relationship of hyaluronic acid (HA) with various molecular weights concerning the structure of hydrogel materials. This study aims to address this need by utilizing aminated hyaluronic acid (AHA) and aldehyde-modified dextran (DA) to prepare dextran-based hyaluronic acid hydrogels (DA-AHA) via Schiff base reaction, imbuing them with acute inflammation repair and wound healing promotion properties. In vitro, coagulation experiments demonstrated that the DA-AHA hydrogel could rapidly coagulate blood within 60 s. Subsequent animal experiments corroborated these findings, revealing the hydrogel’s efficacy in significantly shortening wound healing time and accelerating wound closure efficiency. Moreover, MTT and live-death experiments affirmed the non-cytotoxic nature of the synthesized hydrogel. The study delved into the structural regularity and wound-healing efficacy of DA-AHA hydrogel materials featuring various molecular weights. Additionally, it compared the hemostatic and wound-healing properties of (high molecular weight dextran-aminated hyaluronic acid hydrogel) HDA-AHA, demonstrating its superiority in both aspects.

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合成一系列用于伤口愈合敷料的葡聚糖基 DA-AHA 水凝胶
由于伤口止血和消炎措施不当,导致伤口疼痛、肿胀和发红,因此迫切需要开发能够及时止血、方便无痛换药和加速伤口闭合的伤口修复材料,以促进皮肤伤口的恢复。然而,关于不同分子量的透明质酸(HA)在水凝胶材料结构中的构象关系,目前还缺乏全面的研究。本研究旨在利用胺化透明质酸(AHA)和醛改性右旋糖酐(DA),通过席夫碱反应制备右旋糖酐基透明质酸水凝胶(DA-AHA),使其具有急性炎症修复和促进伤口愈合的特性。体外凝血实验表明,DA-AHA 水凝胶能在 60 秒内迅速凝固血液。随后的动物实验也证实了这些发现,揭示了该水凝胶在显著缩短伤口愈合时间和加快伤口闭合效率方面的功效。此外,MTT 和活体死亡实验证实了合成水凝胶的无细胞毒性特性。该研究深入探讨了不同分子量的 DA-AHA 水凝胶材料的结构规则性和伤口愈合功效。此外,研究还比较了(高分子量葡聚糖氨基透明质酸水凝胶)HDA-AHA 的止血和伤口愈合性能,结果表明它在这两方面都更胜一筹。
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来源期刊
European Polymer Journal
European Polymer Journal 化学-高分子科学
CiteScore
9.90
自引率
10.00%
发文量
691
审稿时长
23 days
期刊介绍: European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas: Polymer synthesis and functionalization • Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers. Stimuli-responsive polymers • Including shape memory and self-healing polymers. Supramolecular polymers and self-assembly • Molecular recognition and higher order polymer structures. Renewable and sustainable polymers • Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites. Polymers at interfaces and surfaces • Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications. Biomedical applications and nanomedicine • Polymers for regenerative medicine, drug delivery molecular release and gene therapy The scope of European Polymer Journal no longer includes Polymer Physics.
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